What combination activates the classical complement pathway?
Understand the Problem
The question is asking about the classical complement pathway and what components are needed to activate it. The complement system is part of the immune system that enhances (complements) the ability of antibodies and phagocytic cells to clear microbes and damaged cells from an organism, promotes inflammation, and attacks the pathogen's cell membrane. The classical pathway is typically triggered by antigen-antibody complexes.
Answer
Antigen-antibody complexes (IgG or IgM) binding to C1 activate the classical complement pathway.
The classical complement pathway is primarily activated by antigen-antibody complexes, specifically when IgG or IgM antibodies bind to antigens. This complex then triggers the assembly of the C1 complex, initiating the pathway.
Answer for screen readers
The classical complement pathway is primarily activated by antigen-antibody complexes, specifically when IgG or IgM antibodies bind to antigens. This complex then triggers the assembly of the C1 complex, initiating the pathway.
More Information
The classical complement pathway is a key part of the immune system, working to clear pathogens and promote inflammation. Its activation is highly specific, ensuring that the immune response is targeted appropriately.
Tips
A common mistake is thinking that any antibody can activate the classical pathway. It's important to remember that primarily IgG and IgM antibodies are involved.
Sources
- Classical Complement Pathway - an overview | ScienceDirect Topics - sciencedirect.com
- Classical Complement Pathway - Sino Biological - sinobiological.com
- Classical Complement Pathway - an overview | ScienceDirect Topics - sciencedirect.com
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