What characterizes Signature 6 in relation to DNA repair mechanisms?
Understand the Problem
The question is asking about the characteristics of Signature 6 in the context of DNA repair mechanisms, specifically focusing on its relation to various types of genetic alterations and abnormalities in cancer. It prompts the respondent to evaluate different statements to determine which one accurately characterizes Signature 6.
Answer
Deficiency in DNA mismatch repair (MMR) system.
Signature 6 is characterized by a deficiency in the DNA mismatch repair (MMR) system.
Answer for screen readers
Signature 6 is characterized by a deficiency in the DNA mismatch repair (MMR) system.
More Information
Mutational Signature 6 is commonly associated with the failure to properly repair mismatches during DNA replication, leading to an accumulation of errors in the genome.
Tips
Confusing it with other signatures related to different DNA repair defects.
Sources
- Mechanisms underlying mutational signatures in human cancers - pmc.ncbi.nlm.nih.gov
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