What causes neurotransmitter release at the presynaptic neuromuscular junction?
Understand the Problem
The following question is asking about the mechanism that leads to the release of neurotransmitters, specifically at the neuromuscular junction. This involves understanding the roles of different ions and channels in the process of synaptic transmission.
Answer
Neurotransmitter release is caused by an action potential, leading to calcium influx and fusion of synaptic vesicles.
The arrival of an action potential at the presynaptic terminal triggers an influx of calcium ions (Ca2+). This influx promotes the fusion of synaptic vesicles with the presynaptic membrane, leading to the release of neurotransmitters into the synaptic cleft.
Answer for screen readers
The arrival of an action potential at the presynaptic terminal triggers an influx of calcium ions (Ca2+). This influx promotes the fusion of synaptic vesicles with the presynaptic membrane, leading to the release of neurotransmitters into the synaptic cleft.
More Information
The neurotransmitter released at the neuromuscular junction is acetylcholine (ACh).
Tips
A common mistake is forgetting the crucial role of calcium ions (Ca2+) in triggering neurotransmitter release. The action potential itself doesn't directly cause the release; it's the calcium influx that acts as the trigger.
Sources
- Mechanisms of Neurotransmitter Release (Section 1, Chapter 5 ... - nba.uth.tmc.edu
- Neurotransmitter Release and Removal - Neuroscience - NCBI - ncbi.nlm.nih.gov
- Ch. 5: Mechanisms of Neurotransmitter Release - med.uth.edu
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