What are the differences between Type 1, Type 2, and MODY diabetes?
Understand the Problem
The question seems to involve a comparison of diabetes types (Type 1, Type 2, and MODY) based on various factors including genetics, pathophysiology, clinical features, autoantibodies, insulin dependence, family history, associations, and risk of Diabetic Ketoacidosis (DKA).
Answer
Type 1: Autoimmune; Type 2: Insulin resistance; MODY: Genetic mutation.
Type 1 diabetes is autoimmune with absolute insulin deficiency; Type 2 diabetes involves insulin resistance and relative deficiency, progressing to absolute insulin deficiency; MODY results from monogenic mutations, causing ineffective insulin production. Type 1 usually affects thin young people, Type 2 affects older, often overweight individuals, and MODY affects young individuals with a strong family history.
Answer for screen readers
Type 1 diabetes is autoimmune with absolute insulin deficiency; Type 2 diabetes involves insulin resistance and relative deficiency, progressing to absolute insulin deficiency; MODY results from monogenic mutations, causing ineffective insulin production. Type 1 usually affects thin young people, Type 2 affects older, often overweight individuals, and MODY affects young individuals with a strong family history.
More Information
MODY is often misclassified and can be mistaken for Type 1 or 2 due to overlapping symptoms and age of onset. Unlike the others, MODY runs strongly in families and is caused by specific genetic mutations.
Tips
A common mistake is confusing the age of onset and symptoms due to overlapping characteristics. Carefully distinguishing genetic and autoimmune factors helps classify correctly.
Sources
- Differentiating Among Type 1, Type 2 Diabetes, and MODY - pmc.ncbi.nlm.nih.gov
- Maturity-Onset Diabetes of the Young: Rapid Evidence Review - AAFP - aafp.org
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