The synthetic adrenocorticosteroids, like our endogenous steroids, are substrates for metabolism through CYP3A4; so, as a pharmacist, you need to look at a patient's medication lis... The synthetic adrenocorticosteroids, like our endogenous steroids, are substrates for metabolism through CYP3A4; so, as a pharmacist, you need to look at a patient's medication list for strong inducers and inhibitors of CYP3A4 for possible DDIs when dispensing this class of drug. True or False?
Understand the Problem
The question is asking whether synthetic adrenocorticosteroids are substrates for metabolism through CYP3A4, implying a need for pharmacists to consider potential drug-drug interactions (DDIs) when dispensing this class of drug.
Answer
True.
The final answer is True.
Answer for screen readers
The final answer is True.
More Information
Synthetic adrenocorticosteroids are metabolized by CYP3A4, an enzyme involved in metabolizing many drugs. Checking for CYP3A4 inducers and inhibitors is crucial for avoiding drug-drug interactions (DDIs).
Tips
A common mistake would be overlooking the enzyme's wide substrate range, leading to potential interactions being missed.
Sources
- Biochemistry, Cytochrome P450 - StatPearls - NCBI Bookshelf - ncbi.nlm.nih.gov
- Drug Metabolism - The Importance of Cytochrome P450 3A4 - medsafe.govt.nz
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