The phosphoinositide cascade is characterized by the activation of phospholipase C that initiates a sequence of events including all of the following except: a. conversion of PIP2... The phosphoinositide cascade is characterized by the activation of phospholipase C that initiates a sequence of events including all of the following except: a. conversion of PIP2 to PIP3. b. increase in cytosolic Ca2+ concentration. c. release of DAG from PIP2. d. activation of protein kinase C. e. phosphorylation of target proteins on serine/threonine residues.
Understand the Problem
The question is asking which of the listed events is NOT part of the phosphoinositide cascade, a signaling pathway triggered by the activation of phospholipase C.
Answer
A. conversion of PIP2 to PIP3.
The phosphoinositide cascade, when phospholipase C is activated, does not include the conversion of PIP2 to PIP3. Therefore, the answer is A.
Answer for screen readers
The phosphoinositide cascade, when phospholipase C is activated, does not include the conversion of PIP2 to PIP3. Therefore, the answer is A.
More Information
The phosphoinositide cascade is a signaling pathway that involves the hydrolysis of PIP2 by phospholipase C, producing DAG and IP3. IP3 then leads to an increase in cytosolic calcium concentration, while DAG activates protein kinase C. These events lead to phosphorylation of target proteins.
Tips
A common mistake is confusing the order of events in the cascade or misidentifying the products of PIP2 hydrolysis.
Sources
- Second Messengers - PMC - pmc.ncbi.nlm.nih.gov
- Signaling cascades in the failing heart and emerging therapeutic ... - nature.com
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