The number of Kringle IV type ______ repeats in the LPA gene is inversely correlated with lipoprotein(a) [Lp(a)] levels.
Understand the Problem
This question is asking about the relationship between the number of Kringle IV type repeats in the LPA gene and lipoprotein(a) [Lp(a)] levels. It requires knowledge of genetics and lipoprotein(a) biology to answer.
Answer
Kringle IV type 2
The number of Kringle IV type 2 repeats in the LPA gene is inversely correlated with lipoprotein(a) [Lp(a)] levels.
Answer for screen readers
The number of Kringle IV type 2 repeats in the LPA gene is inversely correlated with lipoprotein(a) [Lp(a)] levels.
More Information
The LPA gene contains a variable number of Kringle IV type 2 repeats. The number of these repeats is inversely correlated with the concentration of lipoprotein(a) [Lp(a)] in plasma. This means that people with fewer repeats tend to have higher levels of Lp(a).
Tips
It is important to specify Kringle IV type 2, as there are multiple types of Kringle IV repeats within the LPA gene.
Sources
- Lipoprotein(a) beyond the kringle IV repeat polymorphism - pmc.ncbi.nlm.nih.gov
- Low LPA gene kringle IV-2 repeat copy number association with ... - lipidworld.biomedcentral.com
- Apolipoprotein(a) Kringle-IV Type 2 Copy Number Variation ... - PLOS - journals.plos.org
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