The formation of advanced glycation end products (AGEs) contributes to stiffness in blood vessels by cross-linking what molecules?
Understand the Problem
The question asks about the specific type of molecule that is cross-linked by advanced glycation end products (AGEs) in blood vessels, leading to stiffness. This will likely be a molecule found in the vessel walls that contributes to their structure and elasticity.
Answer
AGEs cross-link collagen and other proteins like elastin, increasing blood vessel stiffness.
Advanced glycation end products (AGEs) contribute to stiffness in blood vessels by cross-linking collagen and other proteins, such as elastin.
Answer for screen readers
Advanced glycation end products (AGEs) contribute to stiffness in blood vessels by cross-linking collagen and other proteins, such as elastin.
More Information
Advanced glycation end products (AGEs) are formed through a non-enzymatic reaction between reducing sugars and proteins or lipids. The accumulation of AGEs is associated with aging and several diseases, including cardiovascular disease, diabetes, and Alzheimer's disease.
Tips
A common mistake is to only mention collagen, but AGEs also cross-link with other proteins like elastin. Make sure to include both for a complete answer.
Sources
- Role of advanced glycation end products in cardiovascular disease - pmc.ncbi.nlm.nih.gov
- Advanced Glycation End Products and Their Effect on Vascular ... - pmc.ncbi.nlm.nih.gov
- Advanced Glycation End Products | Circulation - AHA Journals - ahajournals.org
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