Sickle cell disease patient underwent bone marrow transplant. He got a fever and neutropenia 1 day after the procedure and was started on Ceftazidime for a full week but still did... Sickle cell disease patient underwent bone marrow transplant. He got a fever and neutropenia 1 day after the procedure and was started on Ceftazidime for a full week but still did not improve. What to add? A. Consider antiviral B. Ceftriaxone C. Liposomal commercial amphotericin B D. IV Vancomycin
Understand the Problem
The question is asking for the next step in treatment for a sickle cell disease patient who developed fever and neutropenia after a bone marrow transplant and did not improve on Ceftazidime. The options provided suggest a consideration of other possible treatments. The goal is to identify an appropriate addition to the treatment plan.
Answer
Liposomal commercial amphotericin B
The final answer is Liposomal commercial amphotericin B (Option C).
Answer for screen readers
The final answer is Liposomal commercial amphotericin B (Option C).
More Information
In patients undergoing bone marrow transplants, especially those with neutropenia and fever, the risk of fungal infections is high. Adding an antifungal like Liposomal amphotericin B can help in instances where bacterial prophylaxis like Ceftazidime alone does not resolve the fever.
Tips
A common mistake is assuming the fever is only bacterial. Remember that fungal infections are also a risk in immunocompromised patients.
Sources
- Possible Complications after Your Transplant | UAMS Stem Cell - cancer.uams.edu
- Infections associated with neutropenia and transplantation - PMC - pmc.ncbi.nlm.nih.gov
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