Local anesthetics duration of action is related to the drug's binding affinity at the Na+ channel and contributes to what side effect, which is associated with bupivacaine and ropi... Local anesthetics duration of action is related to the drug's binding affinity at the Na+ channel and contributes to what side effect, which is associated with bupivacaine and ropivacaine?
Understand the Problem
The question is asking about the side effect of local anesthetics, specifically bupivacaine and ropivacaine, that is related to the drug's binding affinity at the Na+ channel. You need to choose an option that is most linked to Na+ channel binding side effects.
Answer
Cardiotoxicity
The correct answer is cardiotoxicity.
Answer for screen readers
The correct answer is cardiotoxicity.
More Information
Local anesthetics with high binding affinity, like bupivacaine and ropivacaine, have a longer duration of action but are also associated with cardiotoxicity.
Tips
When answering questions about drug side effects, consider the specific characteristics of the drugs mentioned (e.g., binding affinity) and their known associations with particular adverse effects.
Sources
- Basic pharmacology of local anaesthetics - PMC - PubMed Central - pmc.ncbi.nlm.nih.gov
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