In the context of corneal transplantation, what distinguishes primary graft failures from rejections that occur after initial corneal clearing?
Understand the Problem
The question asks us to differentiate primary graft failures following corneal transplantation from rejections that occur after the cornea initially clears. This requires understanding the underlying causes and characteristics that distinguish these two complications in corneal transplantation.
Answer
Primary graft failure is non-immune related, while rejection is an immune response to the donor cornea.
Primary graft failure is non-immune mediated, arising from issues like poor donor tissue quality. Rejection, however, is an immunological response where the recipient's body recognizes the donor cornea as foreign, typically occurring after an initial period of corneal clarity.
Answer for screen readers
Primary graft failure is non-immune mediated, arising from issues like poor donor tissue quality. Rejection, however, is an immunological response where the recipient's body recognizes the donor cornea as foreign, typically occurring after an initial period of corneal clarity.
More Information
Corneal graft rejection is the most common cause of graft failure in the late postoperative period.
Tips
A common mistake is to assume all graft failures are due to rejection, overlooking non-immunological causes.
Sources
- Corneal Allograft Rejection and Failure - eyewiki.org
- Corneal Graft Rejection - StatPearls - NCBI Bookshelf - ncbi.nlm.nih.gov
- Corneal Graft Rejection Clinical Presentation - Medscape Reference - emedicine.medscape.com
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