In terms of adverse drug reactions, how does chloramphenicol compare to macrolides?
Understand the Problem
The question is asking for a comparison between the adverse drug reactions of chloramphenicol and macrolides. It presents multiple choice options that suggest varying severities and types of adverse effects associated with each drug. The high-level approach to answering involves evaluating the known side effects of both classes of antibiotics.
Answer
Chloramphenicol has more severe adverse effects than macrolides.
Chloramphenicol has a higher risk of severe adverse effects like aplastic anemia, bone marrow suppression, and 'gray baby syndrome' compared to macrolides, which generally cause milder side effects such as gastrointestinal disturbances.
Answer for screen readers
Chloramphenicol has a higher risk of severe adverse effects like aplastic anemia, bone marrow suppression, and 'gray baby syndrome' compared to macrolides, which generally cause milder side effects such as gastrointestinal disturbances.
More Information
Chloramphenicol is associated with rare but potentially life-threatening conditions like aplastic anemia. In contrast, macrolides typically cause less serious adverse effects such as nausea and diarrhea. This makes macrolides generally safer for use than chloramphenicol.
Tips
A common mistake is assuming all antibiotics have similar side effect profiles. It's crucial to understand the specific risks associated with each medication.
Sources
- Chloramphenicol - Wikipedia - en.wikipedia.org
- Chloramphenicol: An overview | ScienceDirect Topics - sciencedirect.com
- Macrolides - Merck Manual Professional Edition - merckmanuals.com
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