How is the horizontal gradient in the loop of Henle generated?
Understand the Problem
The question is asking about the physiological mechanisms that generate the horizontal gradient in the loop of Henle, which is a crucial concept in renal physiology and osmotic regulation. It requires understanding the roles of different limbs of the loop and the movement of solutes and water.
Answer
Countercurrent multiplication generates the gradient.
The horizontal gradient in the loop of Henle is generated by countercurrent multiplication, which involves active reabsorption of NaCl in the thick ascending limbs (TALs) of the nephron.
Answer for screen readers
The horizontal gradient in the loop of Henle is generated by countercurrent multiplication, which involves active reabsorption of NaCl in the thick ascending limbs (TALs) of the nephron.
More Information
Countercurrent multiplication is a mechanism in which fluid flows in opposite directions in adjacent segments of the loop, allowing for the generation of a concentration gradient that helps conserve water and concentrate urine.
Tips
A common mistake is assuming the gradient is solely due to water movement, whereas active transport of ions plays a crucial role.
Sources
- The web page with info on - Example Source - pmc.ncbi.nlm.nih.gov
- Renal physiology: Counter current multiplication - Khan Academy - khanacademy.org
- Chapter 12 Renal Physiology II | BS2001 - Bookdown - bookdown.org
