Define monoclonal antibodies and hybridoma technology
Understand the Problem
The question asks for definitions of two related concepts in biotechnology: monoclonal antibodies and hybridoma technology. Monoclonal antibodies are antibodies made by identical immune cells that are all clones of a unique parent cell. Hybridoma technology is a method for producing large numbers of monoclonal antibodies by fusing antibody-producing B cells with myeloma cells.
Answer
Monoclonal antibodies are identical antibodies from a single B-lymphocyte clone. Hybridoma technology produces these antibodies by fusing B cells with myeloma cells.
Monoclonal antibodies (mAbs) are identical antibodies that bind to the same epitope, derived from a single B-lymphocyte clone. Hybridoma technology is a method for producing large numbers of monoclonal antibodies by fusing B cells with myeloma cells to create hybridoma cells.
Answer for screen readers
Monoclonal antibodies (mAbs) are identical antibodies that bind to the same epitope, derived from a single B-lymphocyte clone. Hybridoma technology is a method for producing large numbers of monoclonal antibodies by fusing B cells with myeloma cells to create hybridoma cells.
More Information
Hybridoma technology was first developed by Georges Köhler and César Milstein in 1975, a breakthrough that earned them the Nobel Prize in Physiology or Medicine in 1984.
Tips
A common mistake is thinking monoclonal antibodies come from multiple B cells. They are produced by a single clone of B cells. Also, hybridomas are not the antibodies themselves, but the cells that produce the antibodies.
Sources
- Monoclonal Antibody Technology | Sino Biological - sinobiological.com
- Hybridoma technology - Wikipedia - en.wikipedia.org
- Hybridoma technology | Sino Biological - sinobiological.com
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