Define Filtration Fraction and Filtration Coefficient. Which factors regulate GFR?
Understand the Problem
The question is asking for definitions of the terms 'Filtration Fraction' and 'Filtration Coefficient' and is also inquiring about the factors that regulate Glomerular Filtration Rate (GFR). This indicates a need for clarity on physiological concepts related to kidney function.
Answer
Filtration fraction (FF) = GFR/RPF. GFR = Kf x net filtration pressure. Regulated by filtration coefficient, pressures, and systemic factors.
Filtration fraction is the ratio of GFR to renal plasma flow, and the filtration coefficient (Kf) is used to determine GFR alongside net filtration pressure. Factors regulating GFR include filtration coefficient (Kf), hydrostatic pressure in glomerular capillaries, osmotic pressure in Bowman's capsule, and systemic factors like blood pressure and blood volume.
Answer for screen readers
Filtration fraction is the ratio of GFR to renal plasma flow, and the filtration coefficient (Kf) is used to determine GFR alongside net filtration pressure. Factors regulating GFR include filtration coefficient (Kf), hydrostatic pressure in glomerular capillaries, osmotic pressure in Bowman's capsule, and systemic factors like blood pressure and blood volume.
More Information
Filtration fraction usually hovers around 20% in healthy individuals and reflects how efficiently kidneys filter blood. Key factors include physical pressures and the filtration surface area in kidneys.
Tips
Confusion often arises between filtration fraction and coefficient. Remember, fraction is a ratio (GFR/RPF), whereas the coefficient is a variable in the GFR equation.
Sources
- Filtration Fraction Explained - Osmosis - osmosis.org
- Physiology, Renal Blood Flow and Filtration - StatPearls - ncbi.nlm.nih.gov
- A simple model for demonstrating the factors affecting glomerular filtration rate - journals.physiology.org
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