A clinical trial is conducted to determine the dose of a new drug required to achieve a specific therapeutic effect (e.g., pain relief) in 50% of the patient population. Which para... A clinical trial is conducted to determine the dose of a new drug required to achieve a specific therapeutic effect (e.g., pain relief) in 50% of the patient population. Which parameter derived from dose-response relationships is the trial primarily attempting to estimate?
Understand the Problem
The question describes a clinical trial aiming to find the drug dosage needed to achieve a therapeutic effect in 50% of patients. We must identify which parameter derived from dose-response relationships this trial is primarily estimating.
Answer
The trial aims to estimate the ED50 (median effective dose).
The clinical trial is primarily attempting to estimate the ED50 (median effective dose). This is the dose at which 50% of the population achieves the desired therapeutic effect.
Answer for screen readers
The clinical trial is primarily attempting to estimate the ED50 (median effective dose). This is the dose at which 50% of the population achieves the desired therapeutic effect.
More Information
The ED50 is a fundamental parameter in pharmacology, providing a benchmark for drug dosing. Understanding the ED50 helps clinicians determine appropriate starting doses and make informed decisions about dose adjustments based on individual patient responses.
Tips
A common mistake is confusing ED50 with LD50 (lethal dose in 50% of the population). ED50 refers to the effective dose for a therapeutic effect, while LD50 refers to the dose that causes death.
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