A 19-year-old girl presents with a short stature, wide-spaced nipples, and primary amenorrhea. What is the most likely karyotype?
Understand the Problem
The question presents a scenario of a 19-year-old female displaying specific clinical features (short stature, wide-spaced nipples, and primary amenorrhea). It then asks you to identify the most probable karyotype associated with these symptoms. This requires knowledge of genetic conditions and their corresponding karyotypes, specifically those that affect female development.
Answer
A. 45X
The most likely karyotype is A. 45X, which is associated with Turner Syndrome.
Answer for screen readers
The most likely karyotype is A. 45X, which is associated with Turner Syndrome.
More Information
The combination of short stature, wide-spaced nipples, and primary amenorrhea is highly suggestive of Turner Syndrome. The most common karyotype associated with Turner Syndrome is 45,X (also written as 45, XO), where a female is missing one of the X chromosomes.
Tips
It is important to remember the common signs and symptoms of genetic disorders like Turner Syndrome to correctly identify the most likely karyotype.
Sources
- 45,X Partial Gonadal Dysgenesis: Turner's Syndrome Variants Mosaic forms of Turner's syndrome (e.g., 45,X/46,XX or other variants) may be seen in female adolescents with spontaneous pubertal onset and primary amenorrhea, and in young women with premature ovarian failure. - sciencedirect.com
- Amenorrhea: Evaluation and Treatment - AAFP - aafp.org
- Evaluation and Management of Amenorrhea - mayoclinicproceedings.org
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