1. Write the reactions catalyzed by the domains of FAs. 2. Calculate the number of ATPs required for FA synthesis for 6C, 10C and 16C fatty acids.
Understand the Problem
The question is asking us to identify the reactions that are catalyzed by the domains of fatty acid synthase (FAS) and to perform calculations related to the ATP required for synthesizing fatty acids of specific chain lengths (6C, 10C, and 16C). This involves understanding the biochemical pathways and energy costs associated with fatty acid metabolism.
Answer
6C requires 10 ATP, 10C requires 18 ATP, and 16C requires 31 ATP.
The reactions catalyzed by the domains of fatty acid synthase (FAS) involve a series of repeating four-step processes: condensation, reduction, dehydration, and another reduction. For fatty acid synthesis, 6C (hexanoic acid) requires 10 ATP, 10C (decanoic acid) requires 18 ATP, and 16C (palmitic acid) requires 31 ATP.
Answer for screen readers
The reactions catalyzed by the domains of fatty acid synthase (FAS) involve a series of repeating four-step processes: condensation, reduction, dehydration, and another reduction. For fatty acid synthesis, 6C (hexanoic acid) requires 10 ATP, 10C (decanoic acid) requires 18 ATP, and 16C (palmitic acid) requires 31 ATP.
More Information
Fatty acid synthase catalyzes the synthesis of long-chain fatty acids by iteratively adding two-carbon units through malonyl-CoA, using ATP in the process. The formation of malonyl-CoA from acetyl-CoA is an ATP-dependent step, requiring 1 ATP per addition.
Tips
A common mistake is to overlook the ATP required for converting acetyl-CoA to malonyl-CoA, which is crucial for the fatty acid elongation process.
Sources
- Fatty Acid Synthesis - Part II (video) - Khan Academy - khanacademy.org
- Determine the number of ATP equivalents needed to form palmitic ... - Vaia - vaia.com
- Fatty Acid Synthesis - Biology LibreTexts - bio.libretexts.org
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