1. How does phosphorylation control the enzyme function? 2. Uncompetitive vs competitive inhibitors. 3. Why do enzymes not work best at extreme pH and temperature? 4. How does end... 1. How does phosphorylation control the enzyme function? 2. Uncompetitive vs competitive inhibitors. 3. Why do enzymes not work best at extreme pH and temperature? 4. How does end product inhibition affect the activity of enzymes? 5. Explain about enzyme transition state in short.
Understand the Problem
The question lists five inquiries related to enzyme function, regulation, and activity. It seeks to understand specific mechanisms and concepts in enzymology.
Answer
1. Alters enzyme activity. 2. Competitive blocks active site; uncompetitive binds to complex. 3. Denature at extremes. 4. Inhibits earlier steps. 5. Stabilizes the high-energy transition state.
- Phosphorylation regulates enzyme function by adding a phosphate group, altering the enzyme's shape and activity. 2. Competitive inhibitors compete for the active site, while uncompetitive inhibitors bind to the enzyme-substrate complex, inhibiting function. 3. Extreme pH and temperature can denature enzymes, disrupting their function. 4. End product inhibition decreases enzyme activity by the final product of the pathway inhibiting an earlier enzyme. 5. The transition state is a high-energy state within the reaction, stabilized by enzymes, lowering the activation energy.
Answer for screen readers
- Phosphorylation regulates enzyme function by adding a phosphate group, altering the enzyme's shape and activity. 2. Competitive inhibitors compete for the active site, while uncompetitive inhibitors bind to the enzyme-substrate complex, inhibiting function. 3. Extreme pH and temperature can denature enzymes, disrupting their function. 4. End product inhibition decreases enzyme activity by the final product of the pathway inhibiting an earlier enzyme. 5. The transition state is a high-energy state within the reaction, stabilized by enzymes, lowering the activation energy.
More Information
Phosphorylation is a reversible switch for enzymes, allowing cells to respond to signals. Enzyme inhibitors are crucial in drug design. Extreme conditions alter enzyme structure, undermining function. End product inhibition is a feedback mechanism ensuring balanced pathway activity. Transition states reduce the energy barrier for reactions.
Tips
A common mistake is confusing uncompetitive inhibitors with noncompetitive inhibitors. Remember, uncompetitive inhibitors only bind to the enzyme-substrate complex.
Sources
- Enzyme regulation (article) | Khan Academy - khanacademy.org
- Enzyme inhibitor - Wikipedia - en.wikipedia.org
- 6.5 Enzymes - Biology 2e | OpenStax - openstax.org
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