1. DNA molecular interactions (a) Draw the 5'-monophosphate-2'-deoxy-cytosine (dC) nucleotide covalently bonded with neighboring DNA nucleotides, similar to the chalkboard drawing... 1. DNA molecular interactions (a) Draw the 5'-monophosphate-2'-deoxy-cytosine (dC) nucleotide covalently bonded with neighboring DNA nucleotides, similar to the chalkboard drawing for 5'-monophosphate-2'-deoxyadenosine (dA). (b) Include hydrogens for the hydrogen bond donating groups of the base (c) Add lone pair electrons for hydrogen bond accepting groups of the base (d) How many hydrogen bonds can the base group make with its watson-crick-franklin partner? (e) How many VDW contacts can the dC:dG base pair make with other base pairs in dsDNA? Hint: Each atom can make a good VDW contact.
Understand the Problem
The question is asking about the molecular structure and interactions of DNA, specifically focusing on the drawing of a nucleotide, inclusion of hydrogen atoms, lone pair electrons, and the bonding capabilities of the nucleotide base. This requires knowledge of molecular biology and DNA structure.
Answer
dC forms 3 H-bonds with dG and multiple VDW contacts.
The dC nucleotide forms 3 hydrogen bonds with dG (guanine), and each atom in the pair can participate in Van der Waals contacts with surrounding bases in the DNA helix structure.
Answer for screen readers
The dC nucleotide forms 3 hydrogen bonds with dG (guanine), and each atom in the pair can participate in Van der Waals contacts with surrounding bases in the DNA helix structure.
More Information
In the DNA helix, cytosine and guanine form a Watson-Crick base pair with three hydrogen bonds, ensuring stable pairing. Van der Waals interactions provide additional stability.
Tips
Ensure proper orientation of hydrogen bond donors and acceptors, and consider 3D structure for VDW contacts.
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