Questions and Answers
What is the drug classification of Zyprexa?
What is the recommended dose range for Zyprexa (olanzapine) in mg/day?
5-20 mg/day
What is the pharmacological action of Zyprexa?
Antagonizes dopamine and serotonin
Which of the following are therapeutic uses of Zyprexa? (Select all that apply)
Signup and view all the answers
Which of the following are side effects or adverse effects of Zyprexa? (Select all that apply)
Signup and view all the answers
What interactions should be avoided when taking Zyprexa?
Signup and view all the answers
What nursing interventions should be taken when administering Zyprexa? (Select all that apply)
Signup and view all the answers
What evaluation suggests the effectiveness of Zyprexa?
Signup and view all the answers
Zyprexa is given by IM injection at _____ mg every 2 weeks.
Signup and view all the answers
Zyprexa may cause _____ as a common side effect.
Signup and view all the answers
Study Notes
Drug Classification
- Zyprexa is classified as an atypical antipsychotic.
Dose Range
- Oral (PO) dosage varies from 5-20 mg/day, tailored to specific diagnoses.
- Depot injection options include:
- Intramuscular (IM) administration of 210 mg every 2 weeks.
- IM administration of 405 mg every 4 weeks.
Pharmacological Action
- The drug acts by antagonizing both dopamine and serotonin receptors.
Therapeutic Uses
- Effective in treating schizophrenia.
- Utilized for acute manic or mixed episodes.
- Employed in maintenance therapy for bipolar I disorder.
- Addresses acute agitation and depressive episodes associated with Bipolar I mania.
- Option for treatment-resistant depression.
Side Effects/Adverse Effects
- Risk of neuroleptic malignant syndrome.
- Possible seizures and suicidal thoughts.
- Monitoring required for increased liver enzyme levels.
- Agranulocytosis may occur.
- Common issues include weight gain, constipation, extrapyramidal symptoms (EPS), and sexual dysfunction.
Medication/Food Interactions
- Concurrent use of Tegretol, omeprazole, or rifampin decreases Zyprexa's effectiveness.
- Zyprexa increases the effects of antihypertensive medications.
- Avoid using IM Zyprexa alongside parenteral benzodiazepines.
Nursing Interventions/Client Education
- Gradually discontinue the medication to prevent withdrawal.
- Educate patients about potential extrapyramidal symptoms and tardive dyskinesia.
- Instruct patients to notify their doctor of suicidal thoughts or any new/worsening mental health symptoms.
- Prior to dose adjustments, monitor EKG, heart rate, and pulse.
- Alert healthcare provider about signs such as anger, violence, fever, bleeding, bruising, rash, and post-injection delirium/sedation syndrome.
- Inform the healthcare provider if pregnant or breastfeeding.
Nursing Administration (Concerns)
- Conduct evaluations of complete blood count (CBC) and liver function during treatment.
- Ocular exams should be performed periodically.
- Monitor for possible decreases in platelets.
- Assess blood glucose levels due to potential metabolic effects.
- Be aware of risks for hyperlipidemia and monitor weight and body mass index (BMI).
- Monitor for neuroleptic malignant syndrome (NMS).
Evaluation of Medication Effectiveness
- Look for decreased excitable, manic behavior.
- Monitor for reductions in delusions and hallucinations related to schizophrenia.
- Evaluate improvements in social interactions and emotional responsiveness.
- Patient should report an increased sense of well-being and reduced agitation.
Studying That Suits You
Use AI to generate personalized quizzes and flashcards to suit your learning preferences.
Description
Test your knowledge on Zyprexa (Olanzapine) with these flashcards. Explore drug classifications, dosage ranges, pharmacological actions, and therapeutic uses. Perfect for medical students and professionals looking to strengthen their understanding of this atypical antipsychotic.
