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Questions and Answers

What is the likely source of the irregular pulse noted during the physical examination?

  • Hypertension
  • Heart block
  • Arrhythmia (correct)
  • Bradycardia
  • Which laboratory finding is likely linked to the process indicated in the microscopic appearance of the left anterior descending artery?

  • Low HDL cholesterol
  • Positive VDRL
  • Elevated platelet count (correct)
  • Low Lp(a)
  • What does the presence of calcified medium-sized arterial branches in the pelvis most likely indicate?

  • Acute vascular injury
  • Aging process
  • Fatty streak formation
  • Long-standing diabetes mellitus (correct)
  • During the physical examination, what does tenderness over the contused area suggest?

    <p>Soft tissue injury may exist (A)</p> Signup and view all the answers

    Which of the following findings would be least likely associated with the presented case of the 59-year-old woman?

    <p>Fracture evident on radiograph (B)</p> Signup and view all the answers

    What is the primary cause of aortic dissection in older adults?

    <p>Hypertension (D)</p> Signup and view all the answers

    What is the significance of the patient's irregular pulse being at 80/min?

    <p>Potential indicator of atrial fibrillation (D)</p> Signup and view all the answers

    Which condition is associated with cystic medial necrosis?

    <p>Aortic dissection (C)</p> Signup and view all the answers

    What role does low HDL cholesterol play in cardiovascular health?

    <p>Increases the risk of atherosclerosis (D)</p> Signup and view all the answers

    In the context of cardiovascular pathology, what does a positive VDRL indicate?

    <p>Syphilis infection (D)</p> Signup and view all the answers

    What is a common complication of aortic dissection?

    <p>Pericardial tamponade (A)</p> Signup and view all the answers

    What is the characteristic appearance of the aorta in tertiary syphilis?

    <p>Tree-bark appearance (A)</p> Signup and view all the answers

    What is the classic presentation of Wegener granulomatosis?

    <p>Sinusitis, hemoptysis, and hematuria (C)</p> Signup and view all the answers

    Which of the following statements is true about Mönckeberg medial calcific sclerosis?

    <p>It is commonly an incidental finding on imaging. (C)</p> Signup and view all the answers

    Which laboratory marker correlates with disease activity in Churg-Strauss syndrome?

    <p>p-ANCA (D)</p> Signup and view all the answers

    What symptoms typically describe an aortic dissection?

    <p>Sharp, tearing chest pain (A)</p> Signup and view all the answers

    What distinguishes Microscopic Polyangiitis from Wegener granulomatosis?

    <p>Absence of nasopharyngeal involvement and granulomas (B)</p> Signup and view all the answers

    What is the most common vasculitis in children?

    <p>Henoch-Schönlein Purpura (C)</p> Signup and view all the answers

    What is the role of hypertension in aortic dissection?

    <p>It results in atrophy of the media. (D)</p> Signup and view all the answers

    What is the standard treatment for rapidly progressive glomerulonephritis associated with Wegener granulomatosis?

    <p>Cyclophosphamide and steroids (C)</p> Signup and view all the answers

    What type of arteries are affected in Mönckeberg medial calcific sclerosis?

    <p>Muscular arteries (A)</p> Signup and view all the answers

    Which symptom is characteristic of Henoch-Schönlein Purpura?

    <p>Palpable purpura on buttocks and legs (C)</p> Signup and view all the answers

    What is the blood pressure threshold for diagnosing systemic hypertension?

    <p>≥ 140/90 mm Hg (B)</p> Signup and view all the answers

    Which type of hypertension is more likely to have a specific underlying cause?

    <p>Secondary hypertension (A)</p> Signup and view all the answers

    Which factor is most likely to be the primary contributor to hypertension in a patient with no serious medical issues?

    <p>Renal retention of excess sodium (C)</p> Signup and view all the answers

    In the pathogenesis of arterial lesions associated with angina pectoris, which cell type is initially targeted?

    <p>Endothelial cells (C)</p> Signup and view all the answers

    Which infectious agent is most likely linked to the development of skin lesions in an HIV-positive patient?

    <p>Human herpesvirus-8 (C)</p> Signup and view all the answers

    What condition is indicated by a chronic cough, nasopharyngeal ulcers, and significant renal impairment?

    <p>Wegener's granulomatosis (C)</p> Signup and view all the answers

    What lifestyle factor is associated with an increased risk of atherosclerosis?

    <p>Smoking (D)</p> Signup and view all the answers

    Which laboratory finding is most indicative of acute renal failure in the context provided?

    <p>Elevated serum creatinine (D)</p> Signup and view all the answers

    What is a common cardiovascular complication arising from atherosclerosis?

    <p>Myocardial infarction (B)</p> Signup and view all the answers

    What is the significance of RBC casts in a urinalysis?

    <p>Evidence of glomerular disease (A)</p> Signup and view all the answers

    What is the most appropriate next step in treating a patient with fasting serum glucose measurements of 170 mg/dL and 200 mg/dL?

    <p>Insulin therapy (B)</p> Signup and view all the answers

    Which vascular lesion is most likely to be present in a patient who has experienced renal arterial thrombosis?

    <p>Atherosclerotic aneurysm (A)</p> Signup and view all the answers

    In a case with a patient presenting with malaise, fever, and significant weight loss, which laboratory finding is most notable?

    <p>Increased serum urea nitrogen (C)</p> Signup and view all the answers

    What condition is likely indicated by the finding of right renal arterial thrombosis during angiography?

    <p>Atherosclerosis (C)</p> Signup and view all the answers

    What laboratory finding is most likely to be positive in a patient experiencing increased cardiac output with normal renal angiograms?

    <p>Lack of angiotensin-converting enzyme (D)</p> Signup and view all the answers

    What might cause abdominal pain and melena 1 week after hemodialysis in a patient?

    <p>Gastrointestinal bleeding (A)</p> Signup and view all the answers

    Which of the following conditions would likely lead to segmental luminal narrowing in the renal arteries?

    <p>Takayasu arteritis (D)</p> Signup and view all the answers

    Which of the following is least likely to be a complication of renal artery thrombosis?

    <p>Interstitial nephritis (D)</p> Signup and view all the answers

    What previous medical condition is most likely associated with the disorientation and difficulty speaking in the 72-year-old woman?

    <p>A stroke (D)</p> Signup and view all the answers

    Based on the findings of a ‘water bottle’ configuration on chest radiograph, what condition is most likely affecting the 72-year-old woman?

    <p>Pericardial effusion (C)</p> Signup and view all the answers

    Which organism is most likely responsible for the findings in the 72-year-old woman?

    <p>Coxsackievirus B (C)</p> Signup and view all the answers

    What does a midsystolic click in heart auscultation typically indicate?

    <p>Mitral valve prolapse (A)</p> Signup and view all the answers

    What is the significance of a cardiac murmur in the 27-year-old woman with fever?

    <p>It suggests possible endocarditis. (A)</p> Signup and view all the answers

    What laboratory finding would most likely suggest hyperparathyroidism?

    <p>High serum calcium (B)</p> Signup and view all the answers

    Which clinical finding is least likely present in the 27-year-old woman with the described symptoms?

    <p>Peripheral edema (D)</p> Signup and view all the answers

    Which echocardiogram finding is most consistent with mitral valve abnormalities?

    <p>Ballooning of the mitral valve leaflet (A)</p> Signup and view all the answers

    Flashcards

    Irregular pulse (80/min)

    A pulse that does not have a consistent rhythm.

    Left Anterior Descending (LAD) artery

    A major coronary artery supplying blood to the front of the heart.

    Low HDL cholesterol

    A low level of 'good' cholesterol in the blood.

    Positive VDRL

    A blood test result indicating a possible infection with syphilis.

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    3-cm contusion (hip)

    A bruise measuring 3 cm across on the patient's hip.

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    Calcified arterial branches (pelvis)

    Radiographic finding of hardened blood vessels in the pelvis.

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    Long-standing diabetes mellitus

    A chronic disease with high blood sugar levels, present for a long time.

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    Benign Essential Hypertension

    A type of high blood pressure with no known identifiable cause.

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    Necrotizing granulomatous vasculitis

    Inflammation of blood vessels, with tissue death and granuloma formation, affecting multiple organs.

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    Wegener's granulomatosis

    A type of necrotizing granulomatous vasculitis, often affecting the nasopharynx, lungs, and kidneys.

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    Microscopic Polyangiitis

    Vasculitis primarily affecting small blood vessels and impacting multiple organs like lungs and kidneys.

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    Churg-Strauss Syndrome

    A type of vasculitis characterized by granulomatous inflammation, eosinophils, and typically impacting the lungs.

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    Henoch-Schönlein Purpura

    IgA-mediated vasculitis, most common in children, presenting with skin rash and GI/kidney issues.

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    Systemic Hypertension

    High blood pressure affecting the entire body, categorized as primary (unknown cause) or secondary (due to another condition).

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    Blood Pressure Threshold

    Blood pressure measurement of 140/90 mmHg or higher is considered high.

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    Normal Blood Pressure

    Blood pressure measurement of typically under 120/80 mmHg.

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    Aortic Dissection

    A tear in the inner lining of the aorta, allowing blood to flow between layers of the vessel wall.

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    Mönckeberg medial calcific sclerosis

    Calcification of muscular arteries (medium-sized) that typically isn't clinically problematic.

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    Aortic aneurysm

    A bulge or widening in the aorta due to weakening of the arterial wall.

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    Hypertension Primary Cause

    Elevated blood pressure with no apparent underlying medical condition or medication use.

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    Angina Pathogenesis

    The development of chest pain associated with exertion caused by impaired blood flow to the heart.

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    Hypertension

    High blood pressure is the most common cause of aortic dissection.

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    Atherosclerosis Risk Factors

    Factors contributing to the formation of plaque buildup in arteries, often leading to heart issues.

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    Vasa vasorum

    Small blood vessels that supply the walls of larger blood vessels, such as the aorta.

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    HIV Skin Lesions

    Specific types of skin abnormalities that can develop in individuals infected with HIV.

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    Hyperplastic arteriolosclerosis

    Thickening and narrowing of the small arteries (arterioles)

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    Cystic medial necrosis

    Weakening of the middle layer (media) of the aorta, caused by fluid-filled sacs.

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    Chronic Cough Causes

    Persistent coughing lasting over several months.

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    Tertiary syphilis

    A late stage of syphilis. Can cause weakening and/or narrowing of the aorta

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    Chronic Kidney Disease (Signs)

    Symptoms like a persistent cough, upper airway ulcers, lung crackles, and high levels of urea and creatinine in the body.

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    Coronary Artery Narrowing

    A condition characterized by reduced blood flow through major arteries of the heart.

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    Atheroma Formation

    The gradual buildup of plaque within arterial walls.

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    Pericardiocentesis

    A procedure to drain fluid around the heart.

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    Bloody fluid in the pericardial sac

    Fluid around the heart is bloody.

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    Water bottle configuration (chest X-ray)

    Heart shape on an X-ray, enlarged and distinctively shaped.

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    Inspiratory decline in systolic pressure.

    Systolic blood pressure decreases during inhalation.

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    Midsystolic click

    Heart sound during the middle of the contraction phase of heart muscle.

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    Nodular deposits with the density of calcium

    Calcium deposits on a valve.

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    Mitral valve balloon appearance

    Mitral valve is bulging upwards.

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    Ejection fraction of 55%

    Percentage of blood pumped out of the heart with each contraction.

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    High fasting glucose (170-200 mg/dL)

    Blood sugar levels above the normal range after fasting, suggesting potential diabetes or glucose intolerance.

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    Right renal arterial thrombosis

    Blood clot blocking blood flow in the artery supplying the right kidney.

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    Elevated urea nitrogen (58 mg/dL) and creatinine (6.7 mg/dL)

    High levels of urea nitrogen and creatinine in the blood, indicating kidney dysfunction.

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    Segmental luminal narrowing with focal aneurysmal dilation (left renal artery)

    Part of the left renal artery showing narrowing and small balloon-like swellings.

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    Abdominal pain and diarrhea after hemodialysis

    Symptoms appearing after a dialysis session, potentially related to the dialysis itself or other complications.

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    Melena (black, tarry stool)

    Dark, tarry stool due to digested blood, often indicating bleeding in the upper digestive tract.

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    Possible serological marker for syphilis

    Blood test(s) for a possible infectious disease that can damage blood vessels.

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    Increased cardiac output and peripheral vascular resistance

    Higher than normal blood flow throughout the body and increased pressure in smaller blood vessels, indicative of certain medical conditions related to blood vessels.

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    Study Notes

    CVS Pathology Material - Study Notes

    • Study Goal: To create 50 multiple-choice questions (MCQs) covering all topics in the provided material. Questions should include logical explanations of answers and tables comparing answers by etiology, pathology, clinical manifestations, and treatment.

    • Question File Format: MCQ format with detailed answer explanations. Tables will be included for comparison.

    • Case Study Example: A 55-year-old woman experiences chest pain, predictably triggered by climbing stairs, that her mother also had at a similar age. This case exemplifies stable angina pectoris.

    • Cardiac Conditions and Relevant Data:

      • Arrhythmia: Irregular heart rhythm due to abnormal electrical activity. Symptoms include palpitations, dizziness, and fainting.
      • Myocardial Infarction (MI): Complete or near complete blockage of a coronary artery, often caused by a blood clot (thrombus). Severe, crushing chest pain radiating to the jaw, left arm or back.
      • Prinzmetal Angina: Temporary narrowing of coronary arteries, often triggered by cold temperatures or stress. Severe chest pain, typically at rest or during sleep.
      • Stable Angina Pectoris: Predictable chest pain, triggered by exertion, relieved by rest or nitroglycerin. Atherosclerosis (narrowing of coronary arteries) leading to reduced blood flow during exertion is the key cause.
      • Unstable Angina Pectoris: Severe blockage in a coronary artery, similar to stable angina but potentially more severe. Chest pain, possibly occurring at rest and potentially worsening, potentially associated with ECG changes.
    • Other Topics Covered: The provided text also includes information about vascular pathology, including basic principles of vasculitis (inflammation of blood vessels), large-vessel vasculitis (such as temporal arteritis and Takayasu arteritis), medium-vessel vasculitis (like polyarteritis nodosa), small-vessel vasculitis (such as Wegener granulomatosis and microscopic polyangiitis), and various vascular tumors (such as hemangiomas and sarcoma). The text also covers hypertension (both primary and secondary) and arteriosclerosis (pathological hardening of the arteries), covering atherosclerosis, arteriolosclerosis, and Mönckeberg medial calcific sclerosis. The material addresses further cardiovascular conditions like aortic dissection and aneurysm, including thoracic and abdominal aortic aneurysm. It covers ischemic heart disease, angina and myocardial infarction, and related complications. It also details various vascular pathologies (including inflammatory conditions and tumors) and cardiovascular abnormalities like congenital defects, including ventricular septal defects and atrial septal defects. The material also covers vasculitis and related conditions.

    • Further Study: The material suggests important factors associated with each condition and possible treatment options. Further study should involve actively engaging with detailed descriptions of each disease.

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