33 Questions
What epithelial structure does the epidermis have?
Stratified Squamous
What epithelial structure does the liver have?
Cuboid
What epithelial structure does the GI tract have?
Columnar
Na+ Ion channels are on the (insert here) surface
Apical
Na+/K+ ATPase are on the (insert here) surface
Basolateral surface
What types of folding can epithelial achieve?
Straight, coiled and branching
What is an example of polarity with organelles?
Basal layer of the kidney proximal tubules having mitochondria
What is microvilli for?
Increasing SA
What is cilia for?
Motility
What are basal folds for?
Increase SA
What is an example that Occludins modulate in tight junctions?
Paracellular permeability
What claudin is found in leaky epithelial?
Claudin 2
What Claudin is found in the epidermis?
Claudin 1
What Claudin is found in the cochlea?
Claudin 4
What Claudin is found in the respiratory tract, urinary tract, GI tract?
Claudin 3
What are the examples of JAMs (Junction Adhesion Molecules)
Ig superfamily CAMs, and N-CAMS
Ig superfamily CAMs are Ca2+ dependent?
False
What interactions do Ig Superfamily CAMs do?
Homophilic and heterophilic interactions
Examples of such interactions?
Axon guidance, cell migration
Ig Superfamily CAMs associated proteins: Receptor Tyrosine (insert here), and Receptor Protein Tyrosine (insert here)
Kinase, and Phosphatase
What happens when there is no N-CAM in a mouse?
Neuronal precursors do not migrate to olfactory bulb, making it smaller
High sialic acid does what to N-CAMS?
Gives it low affinity, rearrangement
Low sialic acid does what to N-CAMs
High affinity, stable tissues
Cadherins are ___ dependent, and are _________
Ca2+, homophobic
What role do Cadherins have?
Cell adherence, especially in histology
What are the non-classical cadherins that are heterophilic?
Desmogleins and Desmocollins
What are the non-classical cadherins that make desmosomes appear darker in appearance?
Plakoglobins and Plakophilins
What do Catenins do?
Link cadherins to actin cytoskeleton, and send signals to the nucleus - altering gene expression (B-catenin)
Integrins - B1 subunit is used where?
Widespread use
What is B2 used for?
White Cells
What is B3 used for?
Platalets
What is B4 used for?
Intermediate filaments
What is the permeability of Connexions
1000Da
Test your knowledge about the epithelial structures of the epidermis, liver, and GI tract, as well as the locations of Na+ ion channels and Na+/K+ ATPase. Explore the different types of folding that epithelial cells can achieve.
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