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Untitled Quiz

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Questions and Answers

Which of the following biologic DMARDs is specifically classified as a TNF-alpha neutralizing agent?

  • Anakinra
  • Infliximab (correct)
  • Abatacept
  • Rituximab

    • What is the role of IL-1 neutralizing agents in the immune response?

  • They deplete B cells.
  • They enhance T cell activation.
  • They promote the production of leukotrienes.
  • They neutralize the effects of IL-1. (correct)

    • Which NSAID is categorized as a pyrrolealkanoic acid derivative?

  • Indomethacin
  • Meclofenamic acid
  • Phenylbutazone
  • Tolmetin (correct)

    • What is a major consequence of a chronic inflammatory response?

    <p>Release of multiple cytokines and chemokines.</p> Signup and view all the answers

    Which of the following NSAIDs is known to exert antipyretic effects?

    <p>Aspirin</p> Signup and view all the answers

    What type of immune cell activation is interfered with by abatacept?

    <p>T cell activation</p> Signup and view all the answers

    Which condition does NOT represent a typical outcome of the immune response?

    <p>Chronic fatigue syndrome</p> Signup and view all the answers

    Which of the following statements about leukotrienes is true?

    <p>They have a chemotactic effect on neutrophils.</p> Signup and view all the answers

    What is the primary metabolic pathway for most NSAIDs?

    <p>Phase I followed by phase II mechanisms</p> Signup and view all the answers

    Which NSAID is classified as a ketone prodrug?

    <p>Nabumetone</p> Signup and view all the answers

    Which of the following is NOT a therapeutic goal in the treatment of inflammation?

    <p>Increasing pain perception</p> Signup and view all the answers

    Which indices are commonly used to assess response in rheumatoid arthritis?

    <p>DAS and ACR Response Index</p> Signup and view all the answers

    What is the significance of enterohepatic circulation in NSAID metabolism?

    <p>It correlates to GI tract irritation</p> Signup and view all the answers

    Which reactive molecules are primarily produced during inflammation due to neutrophil stimulation?

    <p>Free radicals and hydrogen peroxide</p> Signup and view all the answers

    What role does arachidonic acid play in the inflammatory process?

    <p>It generates chemotactic substances</p> Signup and view all the answers

    What is the most important route for the final elimination of NSAIDs?

    <p>Renal excretion</p> Signup and view all the answers

    Which NSAID is noted to be ineffective in treating gout?

    <p>Tolmetin</p> Signup and view all the answers

    What is a potential CNS adverse effect associated with NSAIDs?

    <p>Aseptic meningitis</p> Signup and view all the answers

    Among the following NSAIDs, which one is considered less effective for ankylosing spondylitis compared to others?

    <p>Aspirin</p> Signup and view all the answers

    Which side effect is particularly associated with the use of ketorolac?

    <p>Renal insufficiency</p> Signup and view all the answers

    Which NSAIDs are associated with the greatest overall toxicity?

    <p>Ketorolac and tolmetin</p> Signup and view all the answers

    Which of the following is a gastrointestinal adverse effect of NSAIDs?

    <p>Nausea and vomiting</p> Signup and view all the answers

    Which mechanism of action is NOT listed as an additional possible mechanism for NSAIDs?

    <p>Stimulation of protein synthesis</p> Signup and view all the answers

    For patients with renal insufficiency, which type of salicylates may be considered safest?

    <p>Nonacetylated salicylates</p> Signup and view all the answers

    What characteristic is common among most NSAIDs regarding their protein binding?

    <p>They are highly protein-bound, typically around 98%.</p> Signup and view all the answers

    Which of the following NSAIDs is provided as a single enantiomer?

    <p>Naproxen</p> Signup and view all the answers

    How do NSAIDs differ from glucocorticoids in their effect on disease progression?

    <p>NSAIDs have minimal effect on the progression of the disease.</p> Signup and view all the answers

    What is a known toxicity associated with glucocorticoids?

    <p>Osteoporosis</p> Signup and view all the answers

    Which category of drugs has been shown to have disease-modifying properties in arthritis treatment?

    <p>Low-dose corticosteroids</p> Signup and view all the answers

    What is a characteristic of non-biologic DMARDs?

    <p>They decrease elevated levels of acute phase reactants.</p> Signup and view all the answers

    What mechanism primarily mediates the anti-inflammatory activity of NSAIDs?

    <p>Inhibition of prostaglandin biosynthesis</p> Signup and view all the answers

    Which of the following statements about drugs with short half-lives and their presence in synovial fluid is correct?

    <p>They remain in the joints longer than expected from their half-lives.</p> Signup and view all the answers

    How does diclofenac affect renal function in high-risk patients?

    <p>It impairs renal blood flow and glomerular filtration rate.</p> Signup and view all the answers

    What is the primary reason for limiting diflunisal dosage in patients?

    <p>Its clearance is affected by both hepatic metabolism and renal function.</p> Signup and view all the answers

    Which formulation of flurbiprofen is used for intraoperative miosis?

    <p>Topical ophthalmic formulation.</p> Signup and view all the answers

    For which condition is diflunisal recommended for pain management?

    <p>Cancer pain with bone metastases.</p> Signup and view all the answers

    What is the recommended dosage range for etodolac in osteoarthritis and rheumatoid arthritis?

    <p>300 mg twice or three times a day, up to 500 mg twice a day.</p> Signup and view all the answers

    What is one potential mechanism of action of flurbiprofen apart from COX inhibition?

    <p>Reduction of nitric oxide synthesis.</p> Signup and view all the answers

    What is the average serum half-life of diflunisal compared to salicylic acid?

    <p>Equivalent to salicylic acid.</p> Signup and view all the answers

    What is a common route of administration for diclofenac in Europe?

    <p>Oral mouthwash.</p> Signup and view all the answers

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