16 Questions
: The presence of an enzyme _____ the required energy of activation of a chemical reaction.
lowers
: Generally, as the amount of substrate is increased, the rate of the reaction is _____.
increased
Raising the temperature to over 50C ___ the rate of an enzymatic reaction.
inhibit
Which of the following changes increases the oxygen affinity of hemoglobin?
Shifting the equilibrium toward the R-state.
The Bohr effect refers to:
The right shift in the oxygen saturation curve of hemoglobin at lower pH.
7: Enzymes increase reaction rates by:
Decreasing the energy of activation
The Michaelis constant (Km) is:
The intercept on the 1/v axis.
Choose the correct description of an enzymatic reaction: .
Enzymes decrease the activation energy of reactions, but do not affect the free-energy change, ΔG.
: 2,3-bisphosphoglycerate is:
The product of the glyceraldehyde 3-phosphate dehydrogenase reaction.
Which one of the following cannot be described by the MWC model of allosterism:
negative cooperativity
Which one of the following statements most accurately describes the “rate limiting step” in a metabolic pathway?
The slowest step in the pathway
Which one of the following best describes the symmetry postulate of the MWC (concerted) model of allosterism:
all subunits of an allosteric protein undergo a concerted change when the ligand binds
: Which one of the following is NOT a postulate of the KNF (sequential) model of allosterism:
The binding of the ligand produces a decrease in the affinity of other subunit for the ligand
Lowering the pH for an enzyme that works best in a highly acidic environment ___ the rate for the reaction
increases
In the binding of oxygen to myoglobin, the relationship between the concentration of oxygen and the fraction of binding sites occupied can best be described as:
hyperbolic
Which of the following is not correct concerning 2,3-bisphosphoglycerate (BPG)?
It binds with lower affinity to fetal hemoglobin than to adult hemoglobin.
Test your knowledge of enzymes and allosterism with this quiz. Questions cover topics such as enzymatic reactions, the MWC (concerted) model, and the KNF (sequential) model of allosterism.
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