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Questions and Answers

What is a primary function of connective tissue?

  • Providing thermal insulation
  • Regulating hormonal activity
  • Creating electrical impulses
  • Serving as a medium for nutrient exchange (correct)

Which type of connective tissue fiber is the most abundant?

  • Reticular fibers
  • Fibrin fibers
  • Elastic fibers
  • Collagen fibers (correct)

What type of cells produce elastic fibers?

  • Osteocytes
  • Fibroblasts and smooth muscle cells (correct)
  • Adipocytes
  • Chondrocytes

Which component is NOT part of the extracellular matrix (ECM) in connective tissue?

<p>Neurons (A)</p> Signup and view all the answers

What is the primary constituent of reticular fibers?

<p>Type III collagen (A)</p> Signup and view all the answers

How are collagen fibers assembled?

<p>Involves processes inside and outside fibroblasts (C)</p> Signup and view all the answers

Which of the following statements about the ground substance in connective tissue is true?

<p>It contains specialized molecules like proteoglycans (D)</p> Signup and view all the answers

What role do reticular fibers play in various tissues?

<p>They serve as a supportive framework (A)</p> Signup and view all the answers

What is the primary function of fibroblasts in connective tissue?

<p>Synthesis of collagen and ECM components (D)</p> Signup and view all the answers

Which of the following cells are classified as transient connective tissue cells?

<p>Eosinophils (C)</p> Signup and view all the answers

What do proteoglycan aggregates primarily help regulate in the extracellular matrix?

<p>Water and molecule binding (B)</p> Signup and view all the answers

Where do adult stem cells typically reside?

<p>In specialized locations called niches (D)</p> Signup and view all the answers

What is one key characteristic of mesenchyme, the embryonic connective tissue?

<p>Has a viscous ground substance (B)</p> Signup and view all the answers

Which type of connective tissue is characterized by varying levels of cellularity and matrix composition?

<p>Connective tissue proper (C)</p> Signup and view all the answers

What role do macrophages play in connective tissue?

<p>Phagocytosis and immune response (A)</p> Signup and view all the answers

Which of the following best describes mast cells?

<p>Cells containing mediators of inflammation (B)</p> Signup and view all the answers

What is the primary composition of mucous connective tissue found in the umbilical cord?

<p>Specialized gelatin-like extracellular matrix (C)</p> Signup and view all the answers

Which cells are derived from Wharton's jelly and have stem cell properties?

<p>Wharton's jelly mesenchymal stem cells (B)</p> Signup and view all the answers

Which type of connective tissue is characterized by being abundant in ground substance and thin collagen fibers?

<p>Loose connective tissue (C)</p> Signup and view all the answers

What role does loose connective tissue play in the body?

<p>Facilitating nutrient and waste diffusion (D)</p> Signup and view all the answers

Which of the following best describes dense irregular connective tissue?

<p>Characterized by abundant collagen fibers and few cells (C)</p> Signup and view all the answers

What is the significance of loose connective tissue in relation to the immune system?

<p>It serves as a primary site for immune cell activation (A)</p> Signup and view all the answers

In the classification of dense connective tissue, what are the two basic types based on collagen fiber organization?

<p>Dense regular and dense irregular connective tissue (C)</p> Signup and view all the answers

Which type of stem cells are capable of differentiating into osteocytes, chondrocytes, and adipocytes?

<p>Mesenchymal stem cells (C)</p> Signup and view all the answers

What is the main structural characteristic that distinguishes dense irregular connective tissue?

<p>Fibers arranged in bundles oriented in various directions (D)</p> Signup and view all the answers

What is the primary function of the reticular layer of the dermis?

<p>To offer resistance to tearing from stretching forces (B)</p> Signup and view all the answers

Which of the following best describes the composition of tendons?

<p>Parallel bundles of collagen fibers with fibroblasts between them (D)</p> Signup and view all the answers

How do the fibres in ligaments differ from those in tendons?

<p>Ligament fibers are less regularly arranged compared to tendon fibers (A)</p> Signup and view all the answers

Which tissue layer is referred to as the submucosa and what is its function?

<p>A layer of dense irregular connective tissue that allows organs to resist excessive stretching (D)</p> Signup and view all the answers

What is the role of tendinocytes in tendons?

<p>They separate the collagen fibrils in the tendon (D)</p> Signup and view all the answers

Which characteristic of dense regular connective tissue contributes to its strength?

<p>Ordered and densely packed arrays of fibers (B)</p> Signup and view all the answers

Which of the following structures primarily consists of dense regular connective tissue?

<p>Tendons (C)</p> Signup and view all the answers

What is the key structural feature of aponeuroses?

<p>Fibers arranged in multiple layers at 90° angles (D)</p> Signup and view all the answers

What type of adipose tissue is primarily responsible for thermal regulation in infants?

<p>Brown adipose tissue (D)</p> Signup and view all the answers

What distinguishes white adipose tissue from brown adipose tissue?

<p>Single large lipid droplet in white adipocytes (C)</p> Signup and view all the answers

Which hormone is secreted by white adipose tissue and plays a significant role in energy regulation?

<p>Leptin (C)</p> Signup and view all the answers

Which factor increases the metabolic activity of brown adipose tissue?

<p>Cold exposure (D)</p> Signup and view all the answers

What is a primary function of reticular connective tissue?

<p>Supporting the stroma of lymphatic organs (D)</p> Signup and view all the answers

What triggers the trans-differentiation of adipose tissue?

<p>Cold exposure and physical activity (A)</p> Signup and view all the answers

Which characteristic is NOT associated with brown adipocyte cells?

<p>Larger size compared to white adipocytes (A)</p> Signup and view all the answers

Flashcards

Connective Tissue

Tissue that supports and provides metabolic support to other tissues, containing blood vessels and cells like adipocytes.

Extracellular Matrix

The non-cellular component of connective tissue. It includes fibers and ground substance (proteoglycans, glycoproteins, etc).

Collagen Fibers

Most abundant fibers, providing high tensile strength and flexibility to the connective tissue.

Elastic Fibers

Allow tissues to stretch and return to their original shape.

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Reticular Fibers

Provide support for cells and tissues, abundant in lymph nodes.

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Fibroblasts

Cells responsible for producing collagen, reticular, and elastic fibers.

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Ground Substance

Amorphous component of ECM containing molecules like proteoglycans and glycosaminoglycans.

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Connective tissue functions

Support, defense, nutrient exchange, fat storage, and thermoregulation are the key functions of connective tissue.

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Ground Substance

The component of the extracellular matrix (ECM) that's not fibers; it's rich in proteoglycans, GAGs, and glycoproteins.

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Proteoglycan Aggregates

Giant molecules formed when proteoglycans bind to hyaluronan, regulating movement in the ECM.

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Connective Tissue Cells (Resident)

Cells permanently residing in connective tissue, including fibroblasts, macrophages, adipocytes, mast cells, and adult stem cells.

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Connective Tissue Cells (Wandering)

Cells that migrate through the connective tissue from blood vessels, including lymphocytes, plasma cells, neutrophils, eosinophils, basophils, and monocytes.

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Fibroblasts

The main cells in connective tissue, responsible for making collagen and other ECM components.

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Macrophages

Phagocytic cells in connective tissue, important for immune responses, containing many lysosomes.

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Mesenchyme

Embryonic connective tissue with small, spindle-shaped cells, forming a network, and a viscous ground substance.

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Adipocytes

Specialized fat-storing cells that also produce hormones.

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Dense Irregular Connective Tissue

Connective tissue with collagen fibers arranged in various directions, providing strength to withstand stresses.

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Dense Regular Connective Tissue

Connective tissue with collagen fibers arranged in parallel, providing strength in one direction like a rope.

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Tendons

Cord-like structures connecting muscle to bone, composed of parallel collagen fibers.

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Ligaments

Connective tissue connecting bone to bone, containing less-organized collagen fibers than tendons.

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Aponeuroses

Broad, flattened tendons connecting muscles.

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Reticular Layer

Thick layer of dense irregular connective tissue in the dermis, resisting stretching.

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Submucosa Layer

A layer of dense irregular connective tissue in hollow organs, resisting stretching.

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Epitendineum

Thin connective tissue capsule surrounding tendon substance.

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Aponeurosis Structure

Aponeuroses have collagen fibers arranged in multiple layers at 90° angles to each other, forming dense regular connective tissue.

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Mesenchymal Stem Cells Differentiate into

Mesenchymal stem cells have the ability to transform into various adult connective tissue cells, such as osteocytes, chondrocytes, adipocytes, and neural-like cells.

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White Adipose Tissue Function

White adipose tissue stores energy as triglycerides and produces hormones (adipokines).

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Wharton's Jelly

A specialized, gelatinous extracellular matrix found in the umbilical cord, crucial for supporting the cord's structure.

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Wharton's Jelly Mesenchymal Stem Cells

Cells isolated from Wharton's Jelly that demonstrate the capacity to become various connective tissue types like bone, cartilage, fat, or nerve cells.

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Brown Adipose Tissue Function

Brown adipose tissue generates heat (thermogenesis) by uncoupling lipid oxidation from ATP production.

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Brown Adipose Tissue Abundance

Brown adipose tissue is abundant in newborns but significantly reduced in adults.

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Loose Connective Tissue

Connective tissue with sparse collagen fibers and abundant ground substance, allowing for diffusion and immune response.

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Adipocyte Trans-differentiation

Adipocytes can change from white to brown or brown to white (trans-differentiate) based on the body's needs.

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Dense Irregular Connective Tissue

Dense connective tissue with numerous collagen fibers interwoven in different directions, offering strength in multiple directions.

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Dense Regular Connective Tissue

Dense connective tissue with collagen fibers arranged in parallel bundles, providing strength in one specific direction.

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Reticular Connective Tissue Location

Reticular connective tissue makes up the support framework (stroma) of lymphatic organs like the spleen, lymph nodes, and bone marrow.

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Connective Tissue Proper Subtypes

Connective tissues categorized into loose and dense connective tissue, further divided based on fiber organization.

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White Adipocyte Size

White adipocytes are large cells, often over 100 micrometers in diameter, with a single lipid droplet.

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Brown Adipocyte Characteristics

Brown adipocytes are smaller than white adipocytes and contain many lipid droplets; they generate heat via mitochondrial uncoupling.

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Adult Connective Tissue

Connective tissue forms supportive structures and provides metabolic support, with varying density and fiber arrangement.

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Study Notes

Connective Tissue Overview

  • Connective tissue supports and protects tissues and organs
  • It provides a medium for nutrient exchange
  • It stores fat and regulates thermoregulation
  • It consists of cells and an extracellular matrix (ECM)

Extracellular Matrix (ECM) Composition

  • ECM includes protein fibers (collagen, elastic, reticular)
  • ECM also contains specialized molecules (proteoglycans, multiadhesive glycoproteins, glycosaminoglycans) that form the ground substance

Connective Tissue Fibers

  • Collagen fibers: Most abundant, strong and flexible, formed from collagen fibrils
  • Elastic fibers: Produced by fibroblasts and smooth muscle cells, allow tissues to stretch and recoil
  • Reticular fibers: Composed of type III collagen, provide support for lymphatic tissues and other cells

Ground Substance

  • Composed of proteoglycans, GAGs, and multiadhesive glycoproteins
  • Proteoglycans bind to hyaluronan, forming proteoglycan aggregates
  • Regulates movement, migration of macromolecules, microorganisms, or metastatic cancer cells

Connective Tissue Cells

  • Resident cells: Fibroblasts (myofibroblasts), macrophages, adipocytes, mast cells, and adult stem cells
  • Wandering cells: Lymphocytes, plasma cells, neutrophils, eosinophils, basophils, and monocytes

Fibroblasts

  • Principal cells, responsible for collagen and ECM synthesis
  • Immune response via macrophages with lysosomes

Adipocytes

  • Specialized connective tissue cells storing neutral fat
  • Produce various hormones

Mast Cells

  • Develop in bone marrow, differentiate in connective tissue
  • Contain basophilic granules that store inflammation mediators

Adult Stem Cells

  • Reside in specific locations (niches) in tissues and organs
  • Difficult to distinguish from other connective tissue cells

Connective Tissue Classification

  • Embryonic Connective Tissue: Mesenchyme
  • Adult Connective Tissue:
    • Connective Tissue Proper: Loose (areolar) and Dense (irregular, regular)
    • Specialized Connective Tissue: Adipose, Reticular, Cartilage, Bone, Blood

Embryonic Connective Tissue (Mesenchyme)

  • Primarily found in embryos
  • Contains small, spindle-shaped cells with uniform appearance
  • Processes from these cells create a 3D cellular network
  • Extracellular space filled with viscous ground substance

Mesenchymal Stem Cells

  • Differentiate into various adult connective tissue cells (e.g., osteoblasts, chondrocytes, adipocytes, fibroblasts)

Mucous Connective Tissue (Wharton's Jelly)

  • Present in umbilical cord
  • Specialized, gelatin-like ECM
  • Spindle-shaped cells resembling fibroblasts
  • Contains mesenchymal stem cells capable of differentiating into various cell types

Loose Connective Tissue (Areolar)

  • Cellular, thin collagen fibers, abundant ground substance
  • Viscous, gel-like consistency, facilitates nutrient/waste diffusion

Dense Irregular Connective Tissue

  • Abundant collagen fibers, few cells
  • Collagen fibers arranged in various directions
  • Provides significant strength and resists tearing forces

Dense Regular Connective Tissue

  • Ordered, densely packed collagen fibers, primarily fibroblasts
  • Found in tendons, ligaments, aponeuroses
  • Tendons attach muscle to bone, ligaments join bone to bone

Aponeuroses

  • Broad, flattened tendons
  • Collagen fibers arranged in multiple parallel layers
  • 90° angle between layers

Adipose Tissue

  • Specialized connective tissue for energy homeostasis and hormone production
  • White Adipose: Large lipid droplets, subcutaneous fascia, mammary pads, internal organs
  • Brown Adipose: Smaller, more numerous lipid droplets, abundant in newborns, generates heat

Reticular Connective Tissue

  • Forms stroma of lymphatic tissue, spleen, lymph nodes, bone marrow
  • Stellate reticular cells and complex 3D network of reticular fibers

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