Wound Infections: Sources and Risk Factors

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Questions and Answers

Which of the following wound characteristics would be most indicative of increased susceptibility to infection?

  • A clean abrasion treated promptly with antiseptic solution.
  • A deep puncture wound with necrotic tissue and compromised blood supply. (correct)
  • A surgical incision closed with well-approximated sutures and adequate blood supply.
  • A shallow laceration with minimal bleeding.

A patient undergoing elective surgery is prescribed prophylactic antibiotics. When should these antibiotics ideally be administered to maximize their effectiveness?

  • 24 hours prior to the surgical procedure.
  • Prior to the incision. (correct)
  • Within the first 3 hours post-surgery.
  • Immediately after the surgical procedure.

Which of the following scenarios poses the highest risk of exogenous wound contamination leading to infection?

  • A patient's own skin flora entering a small paper cut.
  • A surgical wound exposed to airborne bacteria in a well-ventilated operating room.
  • A clean surgical wound contaminated with _S. aureus_ from a healthcare worker's hands. (correct)
  • A traumatic wound irrigated with sterile saline solution.

A patient presents with a puncture wound sustained while gardening. Which environmental pathogen is of greatest concern for potential wound infection?

<p><em>Clostridium tetani</em>. (A)</p> Signup and view all the answers

Which factor is least likely to contribute to impaired wound healing and increased risk of infection?

<p>Well-controlled diabetes mellitus. (A)</p> Signup and view all the answers

A patient with a heavily contaminated traumatic wound arrives at the emergency department. What is the most critical initial intervention to reduce the risk of infection?

<p>Irrigating the wound thoroughly with sterile saline. (A)</p> Signup and view all the answers

Post-placenta separation, the endometrial surface is considered a physiological wound. Which characteristic of this wound helps prevent infection?

<p>The rich blood supply facilitates immune cell migration and clearance of pathogens. (C)</p> Signup and view all the answers

What is the rationale behind limiting prophylactic antibiotic use to only high-risk surgical procedures?

<p>To prevent the development of antibiotic-resistant bacteria. (D)</p> Signup and view all the answers

Which of the following patient factors would be least likely to impair the immune response and increase susceptibility to wound infection?

<p>Mild seasonal allergies. (A)</p> Signup and view all the answers

A patient develops a surgical site infection despite appropriate prophylactic measures. What is the most crucial next step in managing this infection?

<p>Obtaining a wound culture to guide targeted antibiotic therapy. (B)</p> Signup and view all the answers

Flashcards

Wounds Prone to Infection

Surgical wounds, traumatic wounds, deep cuts, thermal burns, compound fractures, frostbite necrosis, endometrial surface post-placenta separation, and umbilical stump.

Sources of Wound Infection

Patient’s normal flora, exogenous contamination, and environmental pathogens.

Factors Contributing to Wound Infections

Microbial contamination dose, microbial virulence, wound condition (necrosis, edema, poor oxygenation, poor blood supply, vascular strangulation), and patient’s health status and immune response.

Prevention of Wound Infections

Administering prophylactic antibiotics before surgery (only for high-risk surgeries) and addressing/controlling factors that can contribute to risk of infection.

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Study Notes

  • Wounds susceptible to infection include surgical wounds, traumatic wounds, deep cuts, thermal burns, compound fractures, and frostbite necrosis.
  • Physiological wounds also carry infection risks, such as the endometrial surface post-placenta separation and the umbilical stump.

Sources of Wound Infection

  • Infections can arise from the patient’s normal flora.
  • Abdominal stab wounds can introduce colonic bacteria.
  • Exogenous contamination occurs when a clean surgical wound is contaminated in the OR with S. aureus from hospital staff or fomites.
  • Environmental pathogens like Clostridium tetani spores from soil on a splinter are also sources.

Factors Contributing to Wound Infections

  • Microbial contamination dose influences infection risk.
  • Microbial virulence is a factor.
  • Wound conditions such as necrosis, edema, poor oxygenation, and poor blood supply increase infection risk.
  • Vascular strangulation from tight sutures can contribute.
  • The patient’s health status and immune response play a role.

Prevention of Wound Infections

  • The first 3 hours post-contamination are critical for prevention.
  • Prophylactic antibiotics should be administered before high-risk surgeries.
  • Antibiotics are only given for high-risk surgeries.

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