Wound Healing Techniques

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Questions and Answers

What is one of the prominent manifestations of the acute-phase response?

Skin rashes

Decreased heart rate

Leukocytosis (correct)

Hypoglycemia

What temperature increase is typically observed during a fever associated with the acute-phase response?

3°C to 5°C

1°C to 4°C (correct)

2°C to 3°C

0°C to 2°C

Which of the following represents a common acute-phase protein response?

Decreased body temperature

Increased levels of acute phase proteins (correct)

Increased insulin levels

Decreased cholesterol levels

Fever can often occur in response to which condition?

Infection Signup and view all the answers

Which of the following is NOT a characteristic of fever during the acute-phase response?

Low white blood cell count Signup and view all the answers

What is the normal range for white blood cell count?

4000 - 11000 cells per microliter Signup and view all the answers

What is the primary cause of leukocytosis during bacterial infections?

Accelerated release of WBC from bone marrow Signup and view all the answers

Which type of white blood cell increase is most commonly associated with bacterial infections?

Neutrophils Signup and view all the answers

Which condition is described as a WBC count that may reach 40000 or 100000 cells per microliter?

Leukemoid reaction Signup and view all the answers

Which type of infections is associated with an increase in lymphocytes?

Viral infections Signup and view all the answers

What type of wound healing occurs with a clean, uninfected wound and limited tissue loss?

Healing by first intention Signup and view all the answers

Which of the following best describes healing by first intention?

Is used for surgical incisions Signup and view all the answers

In which situation would healing by second intention most likely occur?

Deep wounds with significant tissue loss Signup and view all the answers

Which of the following is NOT a characteristic of healing by first intention?

Possible infection Signup and view all the answers

Healing by first intention is typically quicker than which type of healing?

Both A and C Signup and view all the answers

What is an outcome of second intention healing compared to first intention healing?

More inflammation because of more tissue loss Signup and view all the answers

Which of the following is a characteristic feature of wounds healing by second intention?

More granulation tissue inflammation Signup and view all the answers

What role do myofibroblasts play in the healing process of wounds by second intention?

Promote contraction phenomena Signup and view all the answers

How long after injury may contraction phenomena occur in wounds healing by second intention?

Within 6 weeks Signup and view all the answers

What is one of the primary differences between first and second intention healing?

First intention results in less scarring Signup and view all the answers

What are hematopoietic cells primarily responsible for in the body?

Generating blood cells Signup and view all the answers

Which of the following describes stable cells?

They remain in the G0 phase but can rapidly divide after injury. Signup and view all the answers

Where are surface epithelia found in the body?

In the skin, GIT, genitourinary system, and glands Signup and view all the answers

What is the normal replicative capacity of stable cells?

They have minimal replicative capacity under normal conditions. Signup and view all the answers

What phase of the cell cycle do stable cells predominantly reside in?

G0 phase Signup and view all the answers

Study Notes

Wound Healing Overview

Two main types of wound healing: healing by first intention (primary union) and healing by second intention.

Healing by First Intention (Primary Union)

Occurs in clean, uninfected wounds with minimal tissue loss, such as surgical incisions.
Characterized by faster recovery and lower inflammation compared to second intention.

Acute Phase Response

Accompanied by an increase in acute phase proteins during the healing process.
Is indicated by the manifestations of fever and leukocytosis.

Leukocytosis

Defined as an elevated white blood cell (WBC) count; normal range: 4,000–11,000 cells per microliter.
High WBC counts in inflammation can reach 15,000–20,000 cells per microliter; can escalate to 40,000 or 100,000 cells per microliter in severe infections (leukemoid reaction).
Leukemoid reaction must be differentiated from leukemia due to similar white cell counts.
Caused by increased release of WBCs from bone marrow in response to cytokines like IL-1 and TNF.

Inflammatory Responses by Infection Type

Bacterial infections typically induce neutrophilia (increased neutrophils).
Viral infections tend to be associated with lymphocytosis (increased lymphocytes).
Parasitic infections can lead to eosinophilia (increased eosinophils).
Certain infections (e.g., typhoid, tuberculosis) may cause leucopenia (decreased WBC).

Healing by Second Intention

Involves more extensive inflammation and tissue loss compared to first intention.
Results in increased granulation tissue and inflammation.
Contraction occurs within six weeks as myofibroblasts reduce wound size.

Cell Types in Wound Healing

Stable cells are quiescent in the G0 phase of the cell cycle and exhibit minimal division under normal conditions.
They have the capability for rapid division when responding to injury, aiding in wound healing.

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Description

This quiz covers the two primary methods of wound healing: healing by first intention and healing by second intention. Understand the processes involved in clean, uninfected wounds and when each method is applicable. Test your knowledge on key concepts related to surgical incisions and tissue loss.