40 Questions
What is the primary function of the proliferative phase in wound healing?
Rebuilding damaged structures and strengthening the wound
Which phase of wound healing is responsible for scar tissue maturation?
Remodelling/Maturation phase
What is the process by which new blood vessels are formed in wound healing?
Neovascularization
What is the purpose of collagen synthesis in wound healing?
To strengthen the wound
What is wound contraction in the context of wound healing?
The process of shrinking the wound size
Which of the following is NOT a phase of wound healing?
Epithelialization phase
What is the primary function of collagen synthesis in wound healing?
To maintain a balance between collagen lysis and synthesis
What is the role of platelets in the hemostatic response during wound healing?
To control blood loss and promote fibrin deposition
Which of the following is a characteristic of the vascular response during wound healing?
Hyperemia and local swelling
What is the primary function of basophils during wound healing?
To produce histamine and increase vascular permeability
What is the role of collagen fiber orientation in wound healing?
To provide strength and structure to the new tissue
Which of the following is a sign of inflammation during wound healing?
Loss of function
What is the primary function of angiogenesis during the proliferative phase?
To supply oxygen and nutrients to the injured and healing tissue
What happens to the number of fibroblasts, macrophages, myofibroblasts, and capillaries during the maturation phase?
They decrease
What type of collagen is initially produced by fibroblasts to tolerate early, controlled movement without disruption?
Collagen type III
When does wound contraction typically begin after injury?
5 days after injury
What is the predominant type of collagen synthesized during the maturation phase?
Type I
What is the primary function of cross-linking between collagen molecules?
To provide further tensile strength to the injured area
What is the role of macrophages in neovascularization?
They are responsible for signaling neovascularization
What happens to the vascularity of the scar tissue during the maturation phase?
It decreases
What is the primary cell type responsible for wound contraction?
Myofibroblasts
What is the main mechanism by which the scar tissue matures during the maturation phase?
Balance of collagen synthesis and lysis
What is the outcome of the replacement of collagen type III by collagen type I during scar tissue maturation?
Stronger scar tissue
What develops in scar tissue as it matures?
Pressure and tension sensitive nerve endings
What is the primary function of fibrin and fibronectin during the inflammatory phase?
Forming a fibrin lattice to limit hemorrhage and fluid loss
Which of the following processes occurs simultaneously during the proliferative phase?
Epithelialization, collagen production, wound contraction, and neovascularization
What is the outcome of the inflammatory phase?
Recruitment of endothelial cells and fibroblasts
What is the main role of macrophages during the inflammatory phase?
Removing damaged tissue and stimulating local repair
What is the primary function of collagen production in wound healing?
Providing strength to the injury site
When does epithelialization occur in the wound healing process?
Within a few hours of injury
What can controlled application of tension increase in the injured area?
Tensile strength
How long does chronic inflammation typically last?
Months or years
What is a factor that can affect the healing process?
All of the above
What is a characteristic of sub-acute inflammation?
Lasts between 2 to 4 weeks
What is a type of factor that can affect wound healing?
Either A or B
What is the significance of controlled application of tension in wound healing?
Increases tensile strength
What is a factor that can affect the tensile strength of the injured area?
Application of stress
What is a characteristic of chronic inflammation?
Lasts for months or years
What can affect the healing process of a wound?
All of the above
What is a type of factor that can affect the healing process?
Systemic factor
This quiz covers the characteristics of the proliferative phase of wound healing, including the role of neovascularization, angiogenesis, and macrophages in the healing process.
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