Wound Healing: Proliferative Phase

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What is the primary function of the proliferative phase in wound healing?

Rebuilding damaged structures and strengthening the wound (correct)

Preparation of the wound for healing

Removal of debris and bacteria

Modification of scar tissue into its mature form

Which phase of wound healing is responsible for scar tissue maturation?

Epithelialization phase

Remodelling/Maturation phase (correct)

Proliferative phase

Inflammatory phase

What is the process by which new blood vessels are formed in wound healing?

Neovascularization (correct)

Collagen synthesis

Angiogenesis

Fibroplasia

What is the purpose of collagen synthesis in wound healing?

To strengthen the wound Signup and view all the answers

What is wound contraction in the context of wound healing?

The process of shrinking the wound size Signup and view all the answers

Which of the following is NOT a phase of wound healing?

Epithelialization phase Signup and view all the answers

What is the primary function of collagen synthesis in wound healing?

To maintain a balance between collagen lysis and synthesis Signup and view all the answers

What is the role of platelets in the hemostatic response during wound healing?

To control blood loss and promote fibrin deposition Signup and view all the answers

Which of the following is a characteristic of the vascular response during wound healing?

Hyperemia and local swelling Signup and view all the answers

What is the primary function of basophils during wound healing?

To produce histamine and increase vascular permeability Signup and view all the answers

What is the role of collagen fiber orientation in wound healing?

To provide strength and structure to the new tissue Signup and view all the answers

Which of the following is a sign of inflammation during wound healing?

Loss of function Signup and view all the answers

What is the primary function of angiogenesis during the proliferative phase?

To supply oxygen and nutrients to the injured and healing tissue Signup and view all the answers

What happens to the number of fibroblasts, macrophages, myofibroblasts, and capillaries during the maturation phase?

They decrease Signup and view all the answers

What type of collagen is initially produced by fibroblasts to tolerate early, controlled movement without disruption?

Collagen type III Signup and view all the answers

When does wound contraction typically begin after injury?

5 days after injury Signup and view all the answers

What is the predominant type of collagen synthesized during the maturation phase?

Type I Signup and view all the answers

What is the primary function of cross-linking between collagen molecules?

To provide further tensile strength to the injured area Signup and view all the answers

What is the role of macrophages in neovascularization?

They are responsible for signaling neovascularization Signup and view all the answers

What happens to the vascularity of the scar tissue during the maturation phase?

It decreases Signup and view all the answers

What is the primary cell type responsible for wound contraction?

Myofibroblasts Signup and view all the answers

What is the main mechanism by which the scar tissue matures during the maturation phase?

Balance of collagen synthesis and lysis Signup and view all the answers

What is the outcome of the replacement of collagen type III by collagen type I during scar tissue maturation?

Stronger scar tissue Signup and view all the answers

What develops in scar tissue as it matures?

Pressure and tension sensitive nerve endings Signup and view all the answers

What is the primary function of fibrin and fibronectin during the inflammatory phase?

Forming a fibrin lattice to limit hemorrhage and fluid loss Signup and view all the answers

Which of the following processes occurs simultaneously during the proliferative phase?

Epithelialization, collagen production, wound contraction, and neovascularization Signup and view all the answers

What is the outcome of the inflammatory phase?

Recruitment of endothelial cells and fibroblasts Signup and view all the answers

What is the main role of macrophages during the inflammatory phase?

Removing damaged tissue and stimulating local repair Signup and view all the answers

What is the primary function of collagen production in wound healing?

Providing strength to the injury site Signup and view all the answers

When does epithelialization occur in the wound healing process?

Within a few hours of injury Signup and view all the answers

What can controlled application of tension increase in the injured area?

Tensile strength Signup and view all the answers

How long does chronic inflammation typically last?

Months or years Signup and view all the answers

What is a factor that can affect the healing process?

All of the above Signup and view all the answers

What is a characteristic of sub-acute inflammation?

Lasts between 2 to 4 weeks Signup and view all the answers

What is a type of factor that can affect wound healing?

Either A or B Signup and view all the answers

What is the significance of controlled application of tension in wound healing?

Increases tensile strength Signup and view all the answers

What is a factor that can affect the tensile strength of the injured area?

Application of stress Signup and view all the answers

What is a characteristic of chronic inflammation?

Lasts for months or years Signup and view all the answers

What can affect the healing process of a wound?