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Whole-Genome Analysis: Microarray vs NGS

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Whole-Genome Analysis: Microarray vs NGS

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Questions and Answers

What are the two types of platforms used for whole-genome analysis?

High-density oligonucleotide microarray and NGS (correct)

Sanger sequencing and RNA-seq

Gene expression analysis and chromatin immunoprecipitation

Low-density oligonucleotide microarray and PCR

What is the primary difference between high-density oligonucleotide microarray and NGS platforms?

One is used for gene expression analysis and the other for genotyping

One is based on PCR and the other is based on sequencing

One is high-throughput and the other is low-throughput

One is used for whole-genome analysis and the other is used for targeted sequencing (correct)

Which of the following is NOT a type of platform used for whole-genome analysis?

Sanger sequencing

NGS

Gene expression analysis (correct)

High-density oligonucleotide microarray

What is the advantage of using high-density oligonucleotide microarray platforms over NGS?

There is no advantage of using high-density oligonucleotide microarray platforms Signup and view all the answers

What is the main purpose of whole-genome analysis?

To determine the sequence of an organism's genome Signup and view all the answers

What is the primary purpose of the DNA probes used in whole-genome analysis techniques?

To span the entire genome at regular intervals Signup and view all the answers

How many DNA probes are typically employed in whole-genome analysis techniques?

500,000 to more than 1,000,000 Signup and view all the answers

What is the benefit of using a high number of DNA probes in whole-genome analysis?

It increases the resolution of the analysis Signup and view all the answers

What is the relationship between the DNA probes and their complementary genomic sequences?

The DNA probes are complementary to their genomic sequences Signup and view all the answers

What is the outcome of using DNA probes that span the entire genome at regular intervals?

A comprehensive analysis of the genome is possible Signup and view all the answers