White Blood Cells: Granulocytes and Agranulocytes

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Questions and Answers

Which of the following statements accurately describes the role of monocytes in the immune response?

  • They are exclusively involved in allergic reactions and parasitic infections.
  • They serve as antigen-presenting cells and mediate immune and inflammatory responses through the production of various substances. (correct)
  • They solely defend the body against bacterial infections through phagocytosis.
  • They primarily function in releasing histamine to mediate allergic responses.

How do basophils contribute to the body's defense mechanisms?

  • By producing antibodies that neutralize bacterial toxins.
  • By releasing histamine, leading to the mediation of allergic responses. (correct)
  • By differentiating into macrophages and phagocytosing pathogens in tissues.
  • By directly attacking and destroying parasitic worms through phagocytosis.

Which characteristic is unique to neutrophils among granulocytes, based on their staining properties?

  • Their granules exclusively take up basic stains.
  • Their granules take up both acidic and basic stains. (correct)
  • They lack granules, distinguishing them from other granulocytes.
  • Their granules exclusively take up acidic stains.

What is the functional distinction between monocytes and macrophages in the immune response?

<p>Monocytes circulate in the bloodstream, whereas macrophages reside in tissues performing phagocytosis. (C)</p> Signup and view all the answers

Eosinophils are primarily involved in which type of immune response?

<p>Allergic reactions and parasitic infections. (B)</p> Signup and view all the answers

If a patient's lab results show an elevated level of eosinophils, which condition would be the most likely cause?

<p>An allergic reaction, such as seasonal allergies. (D)</p> Signup and view all the answers

A patient presents with a bacterial infection. Which type of white blood cell would be the MOST crucial in the initial response to combat this infection?

<p>Neutrophils, due to their phagocytic activity against bacteria. (C)</p> Signup and view all the answers

Which of the following best describes the primary mechanism by which neutrophils combat bacterial infections?

<p>Direct phagocytosis and enzymatic destruction of bacteria. (C)</p> Signup and view all the answers

In an individual experiencing a severe allergic reaction, which type of white blood cell would likely be present in abnormally high numbers?

<p>Basophils, due to their role in releasing histamine. (A)</p> Signup and view all the answers

What role do Langerhans cells play in the immune system, and from which type of white blood cell are they derived?

<p>They present antigens in the skin and mucosa and are derived from monocytes. (B)</p> Signup and view all the answers

Flashcards

Granulocytes

WBCs with granules in their cytoplasm. Includes neutrophils, eosinophils, and basophils.

Agranulocytes

WBCs without granules in their cytoplasm. Includes monocytes and lymphocytes.

Neutrophils

Granulocytes that stain with both acidic and basic dyes. Primary function is phagocytosis of bacteria.

Eosinophils

Granulocytes that stain with acidic dyes. They are involved in allergic reactions and parasitic infections.

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Basophils

Granulocytes that stain with basic dyes. They release histamine and mediate allergic responses.

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Monocytes

Agranulocytes with diverse functions including phagocytosis, intracellular killing, antigen presentation and mediating immune and inflammatory responses.

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Macrophages

Monocytes in tissue that phagocytose microbes

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Study Notes

  • White blood cells (WBCs) are classified into two main categories: granulocytes and agranulocytes, based on the presence or absence of granules in their cytoplasm.

Granulocytes

  • Granulocytes possess granules within their cytoplasm.
  • Neutrophils constitute 90% of granulocytes.
  • Neutrophil granules exhibit affinity for both acidic and basic stains.
  • Eosinophil granules specifically take up acidic stains.
  • Basophil granules exhibit an affinity for basic stains.

Agranulocytes

  • Agranulocytes lack granules.
  • Monocytes are a type of agranulocyte. Functions include phagocytosis, intracellular killing, mediation of immune and inflammatory responses via production of over 100 substances (cytokines, growth factors), and antigen presentation.
  • Tissue monocytes that phagocytose microbes are known as macrophages
  • In the skin and mucosa, monocytes are Langerhans cells.
  • Lymphocytes are the second type of agranulocyte.

Primary Functions of Specific WBCs

  • Neutrophils primarily defend the body against bacteria through phagocytosis and enzymatic destruction.
  • Eosinophils are involved in allergic reactions and parasitic infections.
  • Basophils release histamine and mediate allergic responses.

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