Podcast
Questions and Answers
What is a common issue associated with hydrogels mentioned in the text?
What is a common issue associated with hydrogels mentioned in the text?
- Lack of promoting angiogenesis
- High stability in physiological conditions
- Enhancing neurite extension
- Mechanical instability (correct)
How are fibrin hydrogels formed according to the text?
How are fibrin hydrogels formed according to the text?
- Physical evaporation
- Chemical precipitation
- Enzymatic polymerization (correct)
- Thermal condensation
What is the role of Metalloproteinases (MMPs) mentioned in the text?
What is the role of Metalloproteinases (MMPs) mentioned in the text?
- Stimulating nerve regeneration
- Breaking down proteins (correct)
- Promoting blood supply
- Enhancing cell growth
Which substances are used to control the rate of degradation in tissue engineering according to the text?
Which substances are used to control the rate of degradation in tissue engineering according to the text?
Why are Aprotinin and Tranexamic acid used in tissue engineering as mentioned in the text?
Why are Aprotinin and Tranexamic acid used in tissue engineering as mentioned in the text?
What is a key property of fibrin hydrogels that makes them desirable for tissue engineering according to the text?
What is a key property of fibrin hydrogels that makes them desirable for tissue engineering according to the text?
What determines the biophysical properties of gelatin gels?
What determines the biophysical properties of gelatin gels?
At what temperature does a reverse coil to triple helix transition occur in gelatin gels?
At what temperature does a reverse coil to triple helix transition occur in gelatin gels?
Why are chemical gels with glutaraldehyde preferred over natural methods?
Why are chemical gels with glutaraldehyde preferred over natural methods?
How does pH affect gelatin gel strength in solution?
How does pH affect gelatin gel strength in solution?
Why do physical gelatin gels require crosslinkers for stability?
Why do physical gelatin gels require crosslinkers for stability?
What factor shows the most response in terms of gelation in gelatin gels?
What factor shows the most response in terms of gelation in gelatin gels?
What is gelatin?
What is gelatin?
Which process is used to produce gelatin?
Which process is used to produce gelatin?
What gives gelatin its thermoresponsive properties?
What gives gelatin its thermoresponsive properties?
Why is gelatin considered biocompatible?
Why is gelatin considered biocompatible?
What makes gelatin highly soluble compared to other ECM proteins?
What makes gelatin highly soluble compared to other ECM proteins?
Why is intact protein not necessary for gelatin in tissue engineering applications?
Why is intact protein not necessary for gelatin in tissue engineering applications?
What is the cleavage site on the α chain?
What is the cleavage site on the α chain?
Why is the removal of the 'A' peptide cleavage strictly required for fibrin polymerization?
Why is the removal of the 'A' peptide cleavage strictly required for fibrin polymerization?
What interaction links the center of a fibrin assembly with the ends of two other fibrin assemblies?
What interaction links the center of a fibrin assembly with the ends of two other fibrin assemblies?
What is the function of thrombin in fibrin polymerization?
What is the function of thrombin in fibrin polymerization?
What do knob-hole interactions lead to in fibrin polymerization?
What do knob-hole interactions lead to in fibrin polymerization?
What covers the knobs that are complementary to holes in fibrin polymerization?
What covers the knobs that are complementary to holes in fibrin polymerization?
What are the major disadvantages of using a fibrin-based scaffold for tissue engineering purposes?
What are the major disadvantages of using a fibrin-based scaffold for tissue engineering purposes?
Which method can help reduce the rapid degradation of fibrin-based scaffolds?
Which method can help reduce the rapid degradation of fibrin-based scaffolds?
Why might a fibrin-based scaffold encounter problems with shrinkage during tissue engineering?
Why might a fibrin-based scaffold encounter problems with shrinkage during tissue engineering?
Which strategy can help address the possibility of squishing during sheet formation when using a fibrin-based scaffold?
Which strategy can help address the possibility of squishing during sheet formation when using a fibrin-based scaffold?
What changes can be made to a fibrin-based scaffold to enhance its mechanical stiffness?
What changes can be made to a fibrin-based scaffold to enhance its mechanical stiffness?