Week 4 - Mitosis Flashcards
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Week 4 - Mitosis Flashcards

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Questions and Answers

Define the term 'mitosis'.

A type of cell division where a parent cell divides to produce two genetically identical daughter cells.

Define the term 'chromosome'.

Tightly coiled DNA wrapped around histones - highly condensed chromatin.

Define the term 'centromere'.

Region of a chromosome to which spindle fibers attach, via the kinetochore, during cell division.

Define the term 'centrosome'.

<p>An organelle near the nucleus of a cell, which contains centrioles and from which spindle fibers develop during cell division.</p> Signup and view all the answers

List THREE functions of cell replication.

<ol> <li>Reproduction of unicellular organisms; 2. Formation of gametes (human egg and sperm cells); 3. Growth and repair of tissue.</li> </ol> Signup and view all the answers

Give one implication of mitosis when it goes wrong - what is this implication?

<p>Nondisjunction - This is the failure of homologous chromosomes or sister chromatids to separate properly during cell division. One daughter cell could have missing or extra chromosomes due to the failure to separate properly.</p> Signup and view all the answers

How is DNA arranged in the nucleus?

<p>DNA is stored as chromatin, which condenses to form chromosomes during cell division. Chromatin is a complex of DNA and histone proteins.</p> Signup and view all the answers

What are the products of mitosis?

<p>Two genetically identical daughter cells; genetically identical to each other and to the parent cell.</p> Signup and view all the answers

When does DNA replication occur?

<p>During the S-phase of interphase. Genetic material is replicated so that daughter cells will each receive a complete copy of the parent cell's genetic information.</p> Signup and view all the answers

How do chromosomes appear during INTERPHASE?

<p>During interphase, chromatin appears in its least condensed form - appearing loosely distributed throughout the nucleus.</p> Signup and view all the answers

How do chromosomes appear during PROPHASE?

<p>Chromosomes (sister chromatids joined by central centromere) supercoil. The chromosomes become visible due to the chromatin condensation.</p> Signup and view all the answers

What are the names of the identifiable structures produced during PROPHASE?

<p>Chromosomes become visible; Formation of mitotic spindle fiber from the centrosomes.</p> Signup and view all the answers

What happens during PROPHASE?

<p>Chromatin condenses and becomes visible; Homologous chromosomes form bivalents/tetrads - form synapses. Cross-over occurs forming chiasmata at point of crossover. Spindle microtubules form from the centrosomes. The nuclear envelope and nucleolus break down and disappear. Centrosomes migrate to opposite pole ends of the cell.</p> Signup and view all the answers

What happens during PROMETAPHASE?

<p>Chromosomes continue to condense; Centrioles replicate; Kinetochores appear at the centromeres; Mitotic spindle microtubules attach to the kinetochores.</p> Signup and view all the answers

How do chromosomes appear during METAPHASE?

<p>During metaphase, the cell's chromosomes align themselves at the metaphase plate. The chromosomes, which have been replicated and remain joined at a central point called the centromere, are aligned so that the centromeres are oriented facing the centrosomes at the opposite poles; The mitotic spindle fiber begins to contract.</p> Signup and view all the answers

What are the stages of METAPHASE?

<p>Chromosomes align at the metaphase plate; Each sister chromatid is attached to a spindle fiber, originating from opposite poles. Mitotic fibers attach to kinetochore of centromere.</p> Signup and view all the answers

How do chromosomes appear during ANAPHASE?

<p>Chromosomes break at centromeres, and each sister chromatid moves to opposite poles of the cell.</p> Signup and view all the answers

What happens during ANAPHASE?

<p>Centromere splits into two; Sister chromatids (now chromosomes) are pulled by motor proteins and the condensation of the spindle fibers to opposite poles of the cell; Spindle fibers begin to elongate the cell.</p> Signup and view all the answers

How do chromosomes appear during TELOPHASE?

<p>Chromatids uncoil and decondense back into chromatin form.</p> Signup and view all the answers

What happens during TELOPHASE?

<p>Chromosomes arrive at opposite pole ends; Decondensation of chromosomes occurs; The mitotic spindle fiber breaks down and disappears; Nuclear envelope reforms around each set of chromosomes; Nucleolus reforms at each pole; Cytokinesis occurs in conjunction with telophase.</p> Signup and view all the answers

What happens during CYTOKINESIS?

<p>Cytoplasm is divided between the two daughter cells.</p> Signup and view all the answers

Study Notes

Mitosis Overview

  • Mitosis is a type of cell division producing two genetically identical daughter cells from a parent cell.

Key Terms

  • Chromosome: Tightly coiled DNA around histones; highly condensed chromatin structure.
  • Centromere: Chromosomal region where spindle fibers attach during cell division.
  • Centrosome: Organelle near the nucleus that contains centrioles, vital for spindle fiber development.

Functions of Cell Replication

  • Reproduction of unicellular organisms.
  • Formation of gametes (human sperm and egg).
  • Growth and repair of tissues.

Implications of Mitosis Errors

  • Nondisjunction occurs when homologous chromosomes or sister chromatids fail to separate, leading to cells with missing or extra chromosomes.

DNA Arrangement in the Nucleus

  • DNA exists as chromatin, which condenses into visible chromosomes during cell division, comprising DNA and histone proteins.

Products of Mitosis

  • Results in two daughter cells that are genetically identical to each other and the parent cell.

Timing of DNA Replication

  • DNA replication occurs during the S-phase of interphase, ensuring each daughter cell receives a complete set of genetic information.

Chromosome Appearance During Interphase

  • Chromatin is loosely distributed in the nucleus, representing the least condensed form of DNA.

Chromosome Appearance During Prophase

  • Chromosomes condense and become visible as sister chromatids joined by a centromere; formation of the mitotic spindle begins.

Events During Prophase

  • Chromatin condenses, homologous chromosomes form bivalents/tetrads, and synapses and crossovers occur.
  • The nuclear envelope breaks down, and centrosomes migrate to opposite poles.

Events During Prometaphase

  • The chromosomes continue condensing, centrioles replicate, kinetochores appear, and spindle fibers attach to kinetochores.

Chromosome Alignment During Metaphase

  • Chromosomes align at the metaphase plate with centromeres facing opposite centrosomes, while spindle fibers contract.

Stages of Metaphase

  • Sister chromatids are attached to spindle fibers from opposite poles, with mitotic fibers connecting to the kinetochore.

Chromosome Movement During Anaphase

  • Sister chromatids are pulled apart when the centromeres split, moving to opposite poles of the cell.

Events During Anaphase

  • Spindle fibers contract, pulling chromatids toward opposite poles and elongating the cell.

Chromosome Appearance During Telophase

  • Chromatids decondense back into chromatin as they reach opposite poles.

Events During Telophase

  • Chromosomes decondense, nuclear envelopes reform around each chromatid set, nucleoli reappear, and cytokinesis begins.

Cytokinesis Process

  • Cytoplasm divides between daughter cells, distributing cytoplasmic components to each.

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Test your knowledge on key terms related to mitosis with these flashcards. Each card breaks down important concepts such as mitosis, chromosomes, and centromeres to enhance your understanding of cell division. Perfect for students preparing for biology exams.

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