Week 13 Case Study 2: ProAir® HFA Flashcards

Questions and Answers

What is the generic name for ProAir® HFA Inhalation Aerosol?

Albuterol sulfate (correct)

Formoterol

Beclomethasone

Salbutamol

What is the function of albuterol sulfate?

Used to treat asthma; bronchodilator

Explain how ProAir HFA inhaler is an effective rescue medication for asthma.

Identify the relevant physical and chemical properties of albuterol.

<ol> <li>Racemic mixture: 50:50 of (R)albuterol and (S)albuterol, 2. Molecular weight: 576.7, 3. pKa: 9.3 and 10.3, 4. Solubility: Soluble in water.</li> </ol> Signup and view all the answers

What is the route of administration for ProAir HFA?

Inhalation Signup and view all the answers

What is the role of HFA in ProAir inhalation aerosol?

It serves as the propellant that carries the drug particles. Signup and view all the answers

Identify the FDA approved indications for ProAir® HFA inhalation aerosol.

<ol> <li>Treatment or prevention of bronchospasm in patients 4 years and older, 2) Prevention of exercise-induced bronchospasm in patients 4 years and older.</li> </ol> Signup and view all the answers

What is the total amount of drug delivered with one inhalation of ProAir® HFA?

108 mcg Signup and view all the answers

Why is it necessary to prime a ProAir® inhaler after it has not been used for more than two weeks?

Priming ensures the metering chamber is properly reloaded for an accurate dose. Signup and view all the answers

What could occur if a patient does not follow the recommended cleaning instructions for their inhaler?

Microbial growth may occur, potentially compromising drug delivery. Signup and view all the answers

What is a canister's role in a pMDI/spacer device for asthma treatment?

It provides a pressure-proof container for the medication. Signup and view all the answers

Study Notes

ProAir® HFA Inhalation Aerosol Overview

Generic Name: Albuterol sulfate
Function: Treats asthma as a bronchodilator.

Rescue Medication

ProAir HFA acts quickly to alleviate asthma symptoms, making it an effective rescue medication.

Physical and Chemical Properties of Albuterol

Racemic Mixture: 50:50 ratio of (R)-albuterol and (S)-albuterol.
Molecular Weight: 576.7 g/mol.
pKa Values:
- Phenolic hydroxyl group: pKa = 9.3
- Secondary amine group: pKa = 10.3
Solubility: Soluble in water.

Route of Administration

Method: Inhalation.
Suitability: Optimizes delivery directly to the airways for effective bronchodilation.

HFA as Propellant

HFA serves as the propellant to carry drug particles to the patient's lungs.

FDA Approved Indications

Bronchospasm: For treatment or prevention in patients aged 4 and older with reversible obstructive airway disease.
Exercise-Induced Bronchospasm: For prevention in patients aged 4 and older.

Dosing Information

Each actuation delivers 108 mcg of albuterol sulfate.
Patients may inhale once (108 mcg) or twice (216 mcg total).

Importance of Priming pMDI

Priming ensures the metering chamber is properly filled, providing the correct dose after prolonged storage and preventing suboptimal dosing.

Consequences of Cleaning Neglect

Improper cleaning can lead to microbial growth and obstruction of the nozzle, causing reduced drug delivery and ineffective symptom relief.

Components of pMDI/Spacer Device

Canister: Holds the pressurized medication.
Drug Substance + Propellants: Critical for therapeutic effect and proper delivery.
Metering Valve: Controls the dose expelled.
Actuator: Mechanism to release the dose.
Atomization Orifice: Creates aerosolized mist for inhalation.
Spacer Chamber: Helps enhance drug delivery and allows for increased inhalation time.

Description

Test your knowledge on ProAir® HFA Inhalation Aerosol with these flashcards. Learn about albuterol sulfate, its function as a bronchodilator, and its role as a rescue medication for asthma. Use these cards to prepare for discussions and exams related to asthma treatments.