Podcast
Questions and Answers
What is the generic name for ProAir® HFA Inhalation Aerosol?
What is the generic name for ProAir® HFA Inhalation Aerosol?
What is the function of albuterol sulfate?
What is the function of albuterol sulfate?
Used to treat asthma; bronchodilator
Explain how ProAir HFA inhaler is an effective rescue medication for asthma.
Explain how ProAir HFA inhaler is an effective rescue medication for asthma.
Identify the relevant physical and chemical properties of albuterol.
Identify the relevant physical and chemical properties of albuterol.
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What is the route of administration for ProAir HFA?
What is the route of administration for ProAir HFA?
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What is the role of HFA in ProAir inhalation aerosol?
What is the role of HFA in ProAir inhalation aerosol?
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Identify the FDA approved indications for ProAir® HFA inhalation aerosol.
Identify the FDA approved indications for ProAir® HFA inhalation aerosol.
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What is the total amount of drug delivered with one inhalation of ProAir® HFA?
What is the total amount of drug delivered with one inhalation of ProAir® HFA?
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Why is it necessary to prime a ProAir® inhaler after it has not been used for more than two weeks?
Why is it necessary to prime a ProAir® inhaler after it has not been used for more than two weeks?
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What could occur if a patient does not follow the recommended cleaning instructions for their inhaler?
What could occur if a patient does not follow the recommended cleaning instructions for their inhaler?
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What is a canister's role in a pMDI/spacer device for asthma treatment?
What is a canister's role in a pMDI/spacer device for asthma treatment?
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Study Notes
ProAir® HFA Inhalation Aerosol Overview
- Generic Name: Albuterol sulfate
- Function: Treats asthma as a bronchodilator.
Rescue Medication
- ProAir HFA acts quickly to alleviate asthma symptoms, making it an effective rescue medication.
Physical and Chemical Properties of Albuterol
- Racemic Mixture: 50:50 ratio of (R)-albuterol and (S)-albuterol.
- Molecular Weight: 576.7 g/mol.
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pKa Values:
- Phenolic hydroxyl group: pKa = 9.3
- Secondary amine group: pKa = 10.3
- Solubility: Soluble in water.
Route of Administration
- Method: Inhalation.
- Suitability: Optimizes delivery directly to the airways for effective bronchodilation.
HFA as Propellant
- HFA serves as the propellant to carry drug particles to the patient's lungs.
FDA Approved Indications
- Bronchospasm: For treatment or prevention in patients aged 4 and older with reversible obstructive airway disease.
- Exercise-Induced Bronchospasm: For prevention in patients aged 4 and older.
Dosing Information
- Each actuation delivers 108 mcg of albuterol sulfate.
- Patients may inhale once (108 mcg) or twice (216 mcg total).
Importance of Priming pMDI
- Priming ensures the metering chamber is properly filled, providing the correct dose after prolonged storage and preventing suboptimal dosing.
Consequences of Cleaning Neglect
- Improper cleaning can lead to microbial growth and obstruction of the nozzle, causing reduced drug delivery and ineffective symptom relief.
Components of pMDI/Spacer Device
- Canister: Holds the pressurized medication.
- Drug Substance + Propellants: Critical for therapeutic effect and proper delivery.
- Metering Valve: Controls the dose expelled.
- Actuator: Mechanism to release the dose.
- Atomization Orifice: Creates aerosolized mist for inhalation.
- Spacer Chamber: Helps enhance drug delivery and allows for increased inhalation time.
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Description
Test your knowledge on ProAir® HFA Inhalation Aerosol with these flashcards. Learn about albuterol sulfate, its function as a bronchodilator, and its role as a rescue medication for asthma. Use these cards to prepare for discussions and exams related to asthma treatments.
