Questions and Answers
What is the generic name for ProAir® HFA Inhalation Aerosol?
What is the function of albuterol sulfate?
Used to treat asthma; bronchodilator
Explain how ProAir HFA inhaler is an effective rescue medication for asthma.
Identify the relevant physical and chemical properties of albuterol.
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What is the route of administration for ProAir HFA?
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What is the role of HFA in ProAir inhalation aerosol?
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Identify the FDA approved indications for ProAir® HFA inhalation aerosol.
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What is the total amount of drug delivered with one inhalation of ProAir® HFA?
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Why is it necessary to prime a ProAir® inhaler after it has not been used for more than two weeks?
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What could occur if a patient does not follow the recommended cleaning instructions for their inhaler?
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What is a canister's role in a pMDI/spacer device for asthma treatment?
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Study Notes
ProAir® HFA Inhalation Aerosol Overview
- Generic Name: Albuterol sulfate
- Function: Treats asthma as a bronchodilator.
Rescue Medication
- ProAir HFA acts quickly to alleviate asthma symptoms, making it an effective rescue medication.
Physical and Chemical Properties of Albuterol
- Racemic Mixture: 50:50 ratio of (R)-albuterol and (S)-albuterol.
- Molecular Weight: 576.7 g/mol.
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pKa Values:
- Phenolic hydroxyl group: pKa = 9.3
- Secondary amine group: pKa = 10.3
- Solubility: Soluble in water.
Route of Administration
- Method: Inhalation.
- Suitability: Optimizes delivery directly to the airways for effective bronchodilation.
HFA as Propellant
- HFA serves as the propellant to carry drug particles to the patient's lungs.
FDA Approved Indications
- Bronchospasm: For treatment or prevention in patients aged 4 and older with reversible obstructive airway disease.
- Exercise-Induced Bronchospasm: For prevention in patients aged 4 and older.
Dosing Information
- Each actuation delivers 108 mcg of albuterol sulfate.
- Patients may inhale once (108 mcg) or twice (216 mcg total).
Importance of Priming pMDI
- Priming ensures the metering chamber is properly filled, providing the correct dose after prolonged storage and preventing suboptimal dosing.
Consequences of Cleaning Neglect
- Improper cleaning can lead to microbial growth and obstruction of the nozzle, causing reduced drug delivery and ineffective symptom relief.
Components of pMDI/Spacer Device
- Canister: Holds the pressurized medication.
- Drug Substance + Propellants: Critical for therapeutic effect and proper delivery.
- Metering Valve: Controls the dose expelled.
- Actuator: Mechanism to release the dose.
- Atomization Orifice: Creates aerosolized mist for inhalation.
- Spacer Chamber: Helps enhance drug delivery and allows for increased inhalation time.
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Description
Test your knowledge on ProAir® HFA Inhalation Aerosol with these flashcards. Learn about albuterol sulfate, its function as a bronchodilator, and its role as a rescue medication for asthma. Use these cards to prepare for discussions and exams related to asthma treatments.