15 Questions
What is a potential advantage of wave bioreactors compared to stirred-tank bioreactors?
Reduced foaming
What did Eibl and Eibl achieve in terms of plant cell biomass productivity in wave bioreactors?
40 g/(L.day) with a doubling time of 2 days
What is the main function of specialized membranes in membrane bioreactors?
In situ aeration
What was the result of using a membrane bioreactor for the production of recombinant human alpha-1-antitrypsin (AAT)?
Extracellular product titre close to 250 mg/L
What is an important consideration for relatively slow growing plant cells in membrane bioreactors?
Mass transfer
In tissue culture, which type of culture method involves the carbon source being present at the start of the culture?
Batch culture
What is a major limitation of 2D tissue culture systems such as T-flasks and well-plates?
Non-homogeneous nature
Which type of culture system exhibits concentration gradients of pH, nutrients, toxins, gases and growth factors due to lack of mixing?
Static culture
What is the main challenge in tissue engineering according to the text?
4D challenge due to dynamic tissue growth
Which type of bioreactor is currently used for primary liver cell culture and clinical liver support?
Hollow fiber bioreactor
What is the specific bioreactor developed for clinical liver support that accommodated 400–800 g of primary cells?
Hollow fiber bioreactor
What do biaxial rotating bioreactors with fluidics through in-silico modeling, as reported by Zhang et al. (2009), apply to generate?
Osteogenic bone grafts
What is the main result of using a spontaneous reassembly of primary cells inoculated into a bioreactor established of a scaffold or biomatrix?
Establishment of well-defined liver structures
What does a homogeneous mix of adult liver cells from organ collagenase digestion contain?
Parenchymal hepatocytes, non-parenchymal cells, and liver progenitor cells
What is the main function of bioreactors in tissue engineering according to the text?
Enabling efficient exchange of nutrients and mechanical stimulus necessary for tissue engineered grafts
Learn about the potential application and advantages of using wave bioreactors for cultivating tobacco, grape, and apple suspension cells. Explore the high plant cell biomass productivities achieved and the comparison with stirred-tank bioreactors.
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