Water Balance Mechanisms and Abnormalities
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Questions and Answers

Which of the following is NOT a mechanism that regulates thirst?

  • Increased urine output (correct)
  • Hyperosmolarity
  • Hypovolemia
  • Hypotension
  • In which condition is hypotonic fluid primarily lost?

  • Diarrhea
  • Diabetes insipidus (correct)
  • Vomiting
  • Excessive sweating (correct)
  • What is the total daily water intake for an average individual as indicated?

  • 1.3 L
  • 2.0 L
  • 3.0 L
  • 2.5 L (correct)
  • Which physiological condition leads to decreased urine volume?

    <p>Fasting (B), Increased temperature (D)</p> Signup and view all the answers

    Which of the following correctly describes the relationship between water intake and water loss?

    <p>Water intake is equal to water loss (A)</p> Signup and view all the answers

    What effect does hypervolemia have on the thirst center?

    <p>Inhibits thirst (C)</p> Signup and view all the answers

    What is the daily water loss through sweating and insensible loss combined?

    <p>0.9 L (D)</p> Signup and view all the answers

    Which condition primarily results in loss of isotonic fluid?

    <p>Heat exhaustion (C)</p> Signup and view all the answers

    Which of the following would likely inhibit the thirst response?

    <p>Increased blood volume (B)</p> Signup and view all the answers

    What daily water loss occurs through stool?

    <p>0.2 L (C)</p> Signup and view all the answers

    What hormone inhibits the effect of angiotensin II on thirst?

    <p>Atrial natriuretic peptide (ANP) (A)</p> Signup and view all the answers

    Which condition is characterized by excessive thirst due to a deficiency of ADH?

    <p>Diabetes insipidus (DI) (B)</p> Signup and view all the answers

    What effect does hypertension have on thirst?

    <p>It inhibits thirst (A)</p> Signup and view all the answers

    Which of the following accurately describes dehydration?

    <p>Water +/- salt depletion (C)</p> Signup and view all the answers

    What is the primary function of anti-diuretic hormone (ADH)?

    <p>Control water loss and urine volume (B)</p> Signup and view all the answers

    How does excessive secretion of ADH affect the body?

    <p>Causes edema and hypertension (C)</p> Signup and view all the answers

    What type of dehydration is characterized by loss of both water and sodium?

    <p>Isotonic dehydration (A)</p> Signup and view all the answers

    What is the primary action of aldosterone in the kidneys?

    <p>Reabsorb sodium (and water) (B)</p> Signup and view all the answers

    Which mechanism results in the inhibition of thirst during baroreceptor stimulation?

    <p>Vagus nerve activation (B)</p> Signup and view all the answers

    What condition can result from diuretic therapy affecting urine production?

    <p>Dehydration (D)</p> Signup and view all the answers

    Flashcards

    Water Balance

    The state where the intake of water equals the loss of water.

    Water Intake

    Water consumed through drinking, eating solid foods, and metabolic processes.

    Water Loss

    Water lost through urine, stool, sweating, and insensible loss (like breathing).

    Diarrhea

    A condition where there's a loss of isotonic fluid, meaning fluid with similar salt concentration to blood.

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    Diabetes Insipidus

    A condition where there's a loss of hypotonic fluid, meaning fluid with lower salt concentration than blood.

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    Heat Exhaustion

    A condition where there's a loss of hypotonic fluid due to excessive sweating.

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    Hyperventilation

    A condition where there's a loss of hypotonic fluid caused by rapid, deep breathing.

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    Excessive IV Fluids

    A condition where there's an excess of isotonic fluid due to receiving too much IV fluids.

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    Control of Thirst

    The feeling of thirst is controlled by the thirst center located in the hypothalamus.

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    Excessive Drinking

    A condition where there's an excess of hypotonic fluids due to drinking too much water.

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    What are baroreceptors and where are they located?

    Baroreceptors are specialized sensory receptors found in the aortic arch and carotid bifurcation, playing a crucial role in regulating blood pressure. They sense changes in blood pressure and transmit signals to the brain, inhibiting the thirst center to maintain normal blood pressure.

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    What is Angiotensin II and its role in thirst?

    Angiotensin II is a powerful vasoconstrictor hormone that stimulates thirst and promotes sodium reabsorption in the kidneys, contributing to blood pressure regulation.

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    What is Atrial Natriuretic Peptide (ANP) and how does it affect thirst?

    Atrial natriuretic peptide (ANP) is a hormone secreted by the heart in response to high blood volume and pressure. It counters the effects of Angiotensin II by inhibiting its actions, reducing sodium reabsorption, and promoting fluid excretion, ultimately lowering blood volume and pressure.

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    What does Anti-diuretic hormone (ADH) do?

    Anti-diuretic hormone (ADH), also known as vasopressin, is a hormone primarily produced by the hypothalamus and released by the pituitary gland. It regulates water reabsorption in the kidneys, conserving water in the body and maintaining fluid balance.

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    What is Diabetes Insipidus (DI) and what causes it?

    Diabetes insipidus (DI) is a condition characterized by a deficiency of ADH, resulting in excessive water loss in urine and increased thirst. This happens because the kidneys are unable to effectively reabsorb water, leading to frequent urination and dehydration.

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    What is Syndrome of Inappropriate ADH secretion (SIADH)?

    Syndrome of inappropriate ADH secretion (SIADH) is a condition caused by excessive ADH secretion, leading to water retention, reduced urine output, and potentially causing hypertension and edema. The body holds onto more water than it should.

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    What is dehydration and how is it classified?

    Dehydration refers to a state of water deficiency in the body. It can be classified into three types: isotonic, hypotonic, and hypertonic, depending on the concentration of electrolytes relative to water.

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    What is Isotonic Dehydration?

    Isotonic dehydration refers to a type of dehydration where the concentration of electrolytes (like sodium) in the body remains relatively normal compared to water loss. The body loses equal amounts of water and electrolytes.

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    What is Hypotonic dehydration?

    Hypotonic dehydration (also called hyponatremia) is a type of dehydration where the body loses more electrolytes than water, resulting in a lower sodium concentration in the body. Basically, you lose more salt than water.

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    What is Hypertonic dehydration?

    Hypertonic dehydration (also called hypernatremia) is a type of dehydration where the body loses more water than electrolytes, resulting in a higher sodium concentration in the body. Basically you lose more water than salt.

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    Study Notes

    Water Balance

    • Water balance is maintained when water intake equals water loss.
    • Daily water intake comes from drinking, food and metabolism (1.3L, 0.9L, and 0.3L respectively).
    • Daily water loss comes from urine, stool, and sweating/insensible loss (1.4L, 0.2L, and 0.9L respectively).

    Objectives

    • Explain the mechanism of water balance.
    • Relate water balance to common conditions like diarrhea, excessive sweating, burns, and diabetes insipidus.

    Physiological Abnormalities of Water Balance

    • Exercise: Increased water loss (sweating, hyperventilation) balanced by decreased urine volume and increased intake.
    • Fasting: Decreased water intake balanced by decreased urine volume and increased intake.
    • High temperature: Increased water loss balanced by decreased urine volume and increased intake.

    Pathological Abnormalities of Water Balance

    • Vomiting: Loss of isotonic fluid.
    • Diarrhea: Loss of isotonic fluid.
    • Diabetes insipidus: Loss of hypotonic fluid.
    • Burn: Loss of hypotonic fluid.
    • Heat exhaustion/excessive sweating: Loss of hypotonic fluid.
    • Hyperventilation: Loss of hypotonic fluid.
    • Excessive IV fluid: Excess isotonic fluid.
    • Excessive drinking (Psycogenic): Excess hypotonic fluid.

    Control of Water Intake

    • Thirst center: Located in the hypothalamus.
    • Stimuli for thirst: Hyperosmolarity, hypovolemia, hypotension, angiotensin II.
    • Inhibitors of thirst: Opposite factors + ANP.
      • Osmoreceptors: Located in the hypothalamus and respond to hyperosmolarity in the ECF (extracellular fluid), causing shrinking of the dendrites.

    Control of Water Loss

    • Involves: Kidneys and hormones (e.g., ADH).
    • Kidneys: Reabsorb >99% of filtered water in glomeruli.
      • About 7–13% reabsorption by ADH action.

    Antidiuretic Hormone (ADH)

    • Deficiency of ADH: Increases urine volume (up to 23L/day), causing excessive thirst = diabetes insipidus (DI).
    • Excessive ADH secretion: Reduces urine volume, leads to hypertension and edema due to water retention = Syndrome of Inappropriate ADH Secretion (SIADH).

    Dehydration

    • Water +/− salt depletion
    • Types: Isotonic, hypotonic, hypertonic
      • Isotonic: caused by diarrhea or vomiting, no change in ECF and ICF osmolarity, no change in ICF and ECF volume.
      • Hypotonic: caused by adrenal insufficiency/low aldosterone, decreased ECF osmolarity, increased ICF volume, decreased ICF osmolarity.
      • Hypertonic: caused by Diabetes, sweating or diuretics, increased ECF osmolarity, decreased ICF volume, increased ICF osmolarity.

    General Symptoms & Signs of Dehydration

    • Thirst
    • Dry mouth
    • Rapid heartbeat
    • Headache
    • Dry skin
    • Decreased urination

    Treatment of Dehydration

    • Depends on the type.
    • Treatment of the cause.
    • Intravenous (IV) fluids.
    • Oral Rehydration Salts (ORS).

    Effects of IV Solutions on Body Fluid Compartments

    • Isotonic: No change in ECF or ICF osmolarity or volume.
    • Hypotonic: Increased ECF volume, decreased ECF osmolarity, increased ICF volume and decreased ICF osmolarity.
    • Hypertonic: Increased ECF osmolarity, decreased ICF volume, decreased ICF osmolarity.

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    Related Documents

    Mechanism of Water Balance PDF

    Description

    This quiz explores the concept of water balance in relation to daily intake and loss. It covers physiological and pathological abnormalities affecting water balance, including the effects of exercise, fasting, and conditions such as diarrhea and diabetes insipidus. Test your understanding of how the body regulates water homeostasis.

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