Water as a Nucleophile in Metabolic Reactions

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Which type of molecule is water considered in terms of its nucleophilic properties?

Nucleophile

What atoms of biologic molecules are mentioned as nucleophiles in the text?

Oxygen and nitrogen

Which type of bond is typically cleaved by nucleophilic attack by water?

Amide, glycoside, or ester bonds

In what type of reaction is water a product when monomer units are joined together?

<p>Dehydration synthesis</p> Signup and view all the answers

Which bonds in polypeptides and oligonucleotides are noted as stable in the cell's aqueous environment?

<p>Peptide and phosphoester bonds</p> Signup and view all the answers

Which is a common electrophile mentioned in the text?

<p>Phosphorus atoms in phosphoesters</p> Signup and view all the answers

Where do proteins tend to fold with the R-groups of amino acids with hydrophobic side chains?

<p>In the interior</p> Signup and view all the answers

What do most biomolecules possess in terms of functional groups?

<p>Regions rich in charged or polar functional groups as well as regions with hydrophobic character</p> Signup and view all the answers

What do amphipathic biomolecules have in terms of characteristics?

<p>They possess regions rich in both charged/polar functional groups and hydrophobic character</p> Signup and view all the answers

Which component constitutes the foundation of the plasma membrane of an animal cell?

<p>Bilayer</p> Signup and view all the answers

What type of interactions do the forces involving biomolecules and water have?

<p>Repulsive within the biomolecule and attractive with water</p> Signup and view all the answers

Where are amino acids with charged or polar side chains generally present in proteins?

<p>On the surface</p> Signup and view all the answers

What functional groups on serine, tyrosine, and threonine are points of covalent attachment for phosphoryl groups?

<p>Hydroxyl groups</p> Signup and view all the answers

What type of bonds link amino acids together in a polypeptide chain?

<p>Covalent bonds</p> Signup and view all the answers

What is the primary structure of a polypeptide determined by?

<p>Number and order of amino acid residues</p> Signup and view all the answers

How are aminoacyl residues in peptides named compared to free amino acids?

<p>Replacing the suffix with -yl</p> Signup and view all the answers

In the peptide Lys-Leu-Tyr-Gln, what is the name of the carboxy-terminal residue?

<p>Glutamine</p> Signup and view all the answers

What type of bond is present in the non-α peptide bond linking Glu to Cys in glutathione?

<p>Disulfide bond</p> Signup and view all the answers

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