29 Questions
Which receptors must form a complex of proteins to be activated?
Estrogen receptors on plasma membranes
Which of the following is a clinical use of estrogens?
Suppression of postpartum lactation
Which of the following is an adverse effect of estrogens?
Hyperpigmentation
Which of the following is a native estrogen with selective actions in tissues (NEST)?
Estetrol
Which of the following is an effect of estrogen on the cardiovascular system?
Maintenance of normal structure and function of blood vessels
Which of the following is NOT a nuclear ER effect?
Stimulates breast growth, reduces risk of breast cancer
Which hormone is the major secretory product of the ovary?
Estradiol
During which phase of the menstrual cycle does the corpus luteum secrete estrogen and progesterone?
Luteal phase
Which hormone is a precursor for estrogens in the luteal phase?
Progesterone
Which synthetic estrogen is the primary estrogen used in oral contraceptives?
Ethinyl estradiol
Which synthetic estrogen is 50% less potent than ethinyl estradiol?
Mestranol
Which natural estrogen has a long half-life of 24-28 hours?
Estetrol
Which hormone is converted in the liver to estrone and estriol?
Estradiol
Which of the following is a characteristic of tamoxifen as a selective estrogen receptor modulator (SERM)?
It is activated (agonist) in the uterus and bone.
Which of the following is a characteristic of raloxifene as a selective estrogen receptor modulator (SERM)?
It is used for postmenopausal osteoporosis.
Which of the following is a characteristic of clomiphene as a selective estrogen receptor modulator (SERM)?
It stimulates GnRH, FSH/LH release.
Which of the following is a characteristic of natural progesterone?
It opposes the proliferative action of estrogen in the uterus.
Which of the following is a characteristic of synthetic progestins with androgenic activity?
They increase sebum/acne.
How are progestins given to stimulate or maintain pregnancy during the luteal phase?
They maintain a secretory uterus.
How are progestins given to prevent pregnancy during the follicular phase?
They prevent ovulation.
Which of the following is a function of progestin alone?
Thickens and makes cervical mucus sticky
Which of the following is a use of progestin?
All of the above
Which of the following is a chronic effect of combination agents on ovarian function?
Inhibition of LH and FSH
Which of the following is a mild adverse effect of estrogen-containing agents?
Increased skin pigmentation
Which of the following is a moderate adverse effect of combination agents?
Cholestatic jaundice
Which of the following is a severe adverse effect of estrogen-containing agents?
Cerebrovascular disease
What is the pH range of PhexxiTM, a contraceptive vaginal gel?
3.5-4.5
What is the efficacy of PhexxiTM with 'typical use'?
86%
Which of the following is an adverse effect of PhexxiTM?
Urinary tract infection
Test your knowledge on SERMs, selective estrogen receptor modulators, and their effects on different tissues. Discover the uses of tamoxifen as an antagonist in breast cancer treatment and as an agonist in uterus and bone health. Learn about the potential benefits and adverse effects of this medication.
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