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Questions and Answers

What are the neurological effects observed in infants due to maternal exposure to pesticides and organic compounds during pregnancy?

Neurological and behavioral abnormalities in infants.

What specific congenital issues were noted in children born near fracking sites?

Increased incidence of congenital heart disease.

How did methyl mercury contribute to birth defects in the Minamata bay incident?

Methyl mercury bioaccumulated in fish, leading to pregnant women consuming contaminated seafood, resulting in brain damage and blindness in infants.

Explain the significance of studying fracking chemicals in relation to fertility in animals.

<p>Fracking chemicals led to ranching discontinuation due to animals no longer producing offspring.</p> Signup and view all the answers

What types of endocrine-disrupting compounds were found in water samples taken from fracking sites?

<p>Estrogenic, antiestrogenic, and antiandrogenic compounds.</p> Signup and view all the answers

What are the main characteristics of babies born with Fetal Alcohol Syndrome (FAS)?

<p>Babies with FAS typically exhibit a small head size, an indistinct philtrum, a narrow vermillion, and smaller brain size and development.</p> Signup and view all the answers

During what critical period is the fetus most susceptible to teratogens like alcohol?

<p>The critical period of maximum susceptibility to teratogens is between weeks 3-8 of embryonic development.</p> Signup and view all the answers

How does retinoic acid (RA) act as a teratogen during pregnancy?

<p>Retinoic acid can disrupt neural crest cell migration, leading to various birth defects during its teratogenic period from days 20-35 in humans.</p> Signup and view all the answers

What are the potential outcomes for fetuses exposed to high levels of retinoic acid during pregnancy?

<p>The potential outcomes include birth defects such as absent or defective ears, small jaws, cleft palate, and congenital heart defects.</p> Signup and view all the answers

What is the link between glyphosate herbicides and cranial neural crest defects?

<p>Glyphosate herbicides can upregulate the endogenous production of retinoic acid, leading to cranial neural crest defects and facial disorders when embryos are exposed.</p> Signup and view all the answers

What behavioral and physical symptoms are associated with Fetal Alcohol Spectrum Disorder (FASD)?

<p>FASD includes both physical symptoms similar to FAS and behavioral or mental abnormalities due to prenatal alcohol exposure.</p> Signup and view all the answers

Why can fetal exposure to alcohol cause permanent brain damage before a mother realizes she is pregnant?

<p>Alcohol can damage the fetal brain cells at any stage of early pregnancy, often before women are aware of their pregnancy.</p> Signup and view all the answers

How does the genetic makeup of a fetus influence the effects of alcohol exposure?

<p>The genetic makeup of the fetus can determine its capacity to metabolize alcohol, subsequently affecting the degree of damage incurred.</p> Signup and view all the answers

What are some potential effects of BPA exposure on fetal development?

<p>BPA exposure can lead to abnormalities in fetal gonads, low sperm counts, and may predispose women to breast cancer later in life.</p> Signup and view all the answers

Describe the role of thalidomide in pregnancy outcomes during the early 1960s.

<p>Thalidomide, used for morning sickness, was found to be a teratogen causing serious birth defects.</p> Signup and view all the answers

How might nicotine affect fetal development according to studies on teratogens?

<p>Nicotine is linked to complications such as low birth weight, preterm birth, and increased risk of developmental disorders.</p> Signup and view all the answers

What are some heavy metals known to act as teratogens and their potential effects on fetal development?

<p>Heavy metals like lead and mercury can cause developmental delays, cognitive deficits, and birth defects.</p> Signup and view all the answers

What environmental influences can impact pregnancy outcomes?

<p>Environmental factors such as pollution, chemicals like BPA, and socio-economic conditions can negatively affect pregnancy outcomes.</p> Signup and view all the answers

What specific reproductive health issues can arise from DES exposure?

<p>DES exposure can result in infertility, ectopic pregnancies, and increased cancer risk in the reproductive tract.</p> Signup and view all the answers

How did the use of BPA expand from medicine to industry?

<p>BPA was first synthesized as an estrogenic compound but later became widely used in plastic production.</p> Signup and view all the answers

What was the initial purpose of DES before its harmful effects were recognized?

<p>DES was initially used to prevent miscarriages during pregnancy.</p> Signup and view all the answers

Study Notes

Teratology

  • The study of birth defects that occur during embryonic development.

Teratogens

  • Agents responsible for birth defects, affecting development during critical periods.

Human Teratogens

  • Alcohol:
    • Fetal Alcohol Syndrome (FAS): Characterized by small head size, indistinct philtrum, narrow vermillion, smaller brain size and development.
    • Fetal Alcohol Spectrum Disorder (FASD): Includes physical FAS symptoms, behavioral, and mental abnormalities.
    • Alcohol effects on fetus depend on genetic makeup, maternal alcohol metabolism, and timing of exposure.
    • Even low alcohol consumption during pregnancy can lead to fetal brain cell loss.
    • Damage can occur before pregnancy is known.
  • Retinoic Acid (RA):
    • Vitamin A derivative crucial for axis, jaw, and heart formation.
    • Pharmaceutical form (13-cis-retinoic acid) treats severe cystic acne.
    • High doses in pregnant animals cause birth defects.
    • Human studies show abnormalities like absent/defective ears, jaws, cleft palate, and cardiovascular defects.
    • Affects neural crest cell migration, leading to birth defects.
    • Glyphosate-based herbicides (e.g., Roundup) can increase RA production, causing neural crest defects in animal models.
  • Diethylstilbestrol (DES):
    • Synthetic estrogen previously used to prevent miscarriages.
    • Exposed millions of pregnant women and fetuses between 1947 and 1971.
    • No proven benefits, banned in 1971 due to reproductive health issues.
    • Causes reproductive tract abnormalities, infertility, and cancer in offspring.
  • Bisphenol A (BPA):
    • Synthetic analog of estrogen used in plastic production.
    • Leaches from food containers, exposing humans through food and drink.
    • Found in high levels in urine samples, indicating widespread exposure.
    • May cause reproductive problems, cancer, and behavioral abnormalities.
    • Crosses the placenta and affects animal development.
    • Linked to increased miscarriages and reproductive organ abnormalities.
  • Thalidomide:
    • Mild sedative used for morning sickness.
    • Found to be a potent teratogen, causing severe limb defects in newborns.
  • Pesticides & Organic Compounds:
    • Ingestion during pregnancy can cause neurological and behavioral abnormalities.
    • Minamata Disease: Mercury poisoning from contaminated seafood caused brain damage and blindness in Japanese infants.
  • Fracking Chemicals:
    • Diverse chemicals used in hydraulic fracturing can contaminate groundwater.
    • Estrogenic, antiestrogenic, and antiandrogenic compounds found in water samples.
    • Linked to reproductive problems in animals and possible congenital heart defects in humans.

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