29 Questions
Which type of vulval intraepithelial neoplasia (VIN) is now called low grade squamous intraepithelial lesion (LSIL)?
Usual VIN
What is the most common type of VIN and is associated with high risk types of HPV?
High grade squamous intraepithelial lesion (HSIL)
In which age group does high grade squamous intraepithelial lesion (HSIL) mainly occur?
30 to 50
What is the main risk factor associated with the occurrence of high grade squamous intraepithelial lesion (HSIL)?
Smoking
What may happen to untreated high grade squamous intraepithelial lesion (HSIL) over time?
It may develop into cancer
What typically causes low grade squamous intraepithelial lesion (LSIL)?
High risk types of HPV
Which type of VIN has a higher risk of developing into cancer?
Differentiated VIN
What is the most common histological pattern for vulvar cancer?
Squamous cell carcinoma (SCC)
Which condition is commonly found in women with Differentiated VIN?
Lichen sclerosus
What is the incidence of Extramammary Paget’s disease?
0.53/100,000
Which type of vulvar cancer is associated with lichen sclerosus?
Warty type
What is the best treatment for Differentiated VIN?
Surgical excision
What is the most common age range for the occurrence of Carcinoma of the vulva?
50-60 years
Which type of vulvar cancer is mainly associated with usual VIN and HPV infection?
Basoloid/warty type
From which glandular epithelium does Extramammary Paget’s disease arise?
Apocrine glandular epithelium
What is the most common symptom in patients with Paget’s disease of the vulva?
Pruritus
Which histologic category of Gestational Trophoblastic Neoplasia (GTN) is characterized by aggressive invasion of the endometrium and myometrium by trophoblastic cells?
Invasive mole
What is the approximate incidence of Gestational Trophoblastic Neoplasia (GTN) in the USA and Europe?
1:50,000 pregnancies
What is a significant risk factor for Gestational Trophoblastic Neoplasia (GTN)?
Age > 40 years
Which criteria are used to diagnose Trophoblastic Neoplasia I?
Sustained HCG level plateau 610% of 4 values over a 3-wk duration
What is a high-risk patient characteristic for Gestational Trophoblastic Neoplasia (GTN)?
Excessively high β-HCG titer prior to evacuation
Which histologic category of GTN is characterized by liver or brain metastasis?
Gestational choriocarcinoma
What is the most common malignant form of gestational trophoblastic neoplasia?
Gestational choriocarcinoma
Which type of gestational trophoblastic neoplasia is characterized by invasion of the myometrium or uterine blood vessels?
Invasive mole
Which form of gestational trophoblastic neoplasia tends to develop early blood-borne systemic metastases?
Gestational choriocarcinoma
What is the characteristic feature of placental-site trophoblastic tumor (PSTT)?
Expansive growth mimicking cervical carcinoma
Which stage of gestational trophoblastic neoplasia involves GTN extending to the lungs, with or without known genital tract involvement?
Stage III
At what age does placental-site trophoblastic tumor (PSTT) typically arise?
>40 years
Which form of gestational trophoblastic neoplasia has a characteristic serum marker of HPL (human placental lactogen)?
Placental site trophoblastic disease
Test your knowledge on vulvar lesions, vulval intraepithelial neoplasia, and the types of VIN. Learn about the characteristics and classification of these conditions.
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