Genetic and environmental manipulation of ageing

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Questions and Answers

How much was the lifespan increase associated with the Age-1 mutation?

  • 30%
  • 50% (correct)
  • 40%
  • 20%

What does Age-1 gene encode?

  • WRN
  • PI3K (correct)
  • LMNA
  • ERCC8

What do Daf mutations in the IGF-1 pathway do?

  • Cause a segmental progeriod syndrome
  • Encode PI3K
  • Affect Dauer formation and longevity (correct)
  • ------------------------------

What single gene mutation causes Werner syndrome?

<p>WRN (A)</p> Signup and view all the answers

Do dwarf mice with low levels of IGF-1 live shorter lives?

<p>False (B)</p> Signup and view all the answers

What does dietary restriction NOT do?

<p>Increase metabolic activity (D)</p> Signup and view all the answers

What does rapamycin inhibit?

<p>TOR (B)</p> Signup and view all the answers

How much is the increase in lifespan associated with rapamycin?

<p>10-15% (A)</p> Signup and view all the answers

Do mice over expressing GH live longer lives?

<p>False (B)</p> Signup and view all the answers

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