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Genetic and environmental manipulation of ageing

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Genetic and environmental manipulation of ageing

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Questions and Answers

How much was the lifespan increase associated with the Age-1 mutation?

30%

50% (correct)

40%

20%

What does Age-1 gene encode?

WRN

PI3K (correct)

LMNA

ERCC8

What do Daf mutations in the IGF-1 pathway do?

Cause a segmental progeriod syndrome

Encode PI3K

Affect Dauer formation and longevity (correct)

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What single gene mutation causes Werner syndrome?

WRN Signup and view all the answers

Do dwarf mice with low levels of IGF-1 live shorter lives?

False Signup and view all the answers

What does dietary restriction NOT do?

Increase metabolic activity Signup and view all the answers

What does rapamycin inhibit?

TOR Signup and view all the answers

How much is the increase in lifespan associated with rapamycin?

10-15% Signup and view all the answers

Do mice over expressing GH live longer lives?