VSC329 Week 1: Epidemiology Intro

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Questions and Answers

When investigating a disease outbreak, which objective of veterinary epidemiology focuses specifically on identifying the geographical source and initial conditions that led to the emergence of the disease?

  • Collecting data on the ecology and natural progression of the disease within affected populations.
  • Developing strategies for long-term monitoring and evaluation of disease control efforts following the outbreak.
  • Determining the ORIGIN of a disease whose cause is known. (correct)
  • Assessing the economic impact of the disease, including lost productivity and control costs.

In the context of infectious disease epidemiology, what characterizes the 'latent period'?

  • The entire period an infectious agent remains dormant within a host.
  • The period from initial infection until an individual can transmit the infectious agent, but prior to showing clinical signs. (correct)
  • The duration after which an infected individual recovers and develops immunity.
  • The time during which an individual shows clinical signs of the disease.

Which component of the epidemiological triad primarily concerns the genetic makeup, behavior, and immune status of a population?

  • Vector
  • Host (correct)
  • Environment
  • Agent

What is the most crucial aspect of 'virulence' when assessing the impact of an infectious agent on a host population?

<p>The ability of the agent to cause severe disease or death in infected hosts. (C)</p> Signup and view all the answers

Which of the following mechanisms describes 'transstadial transmission'?

<p>The persistence of an infectious agent through different developmental stages of a vector. (C)</p> Signup and view all the answers

What impact does antigenic variation have on disease control strategies?

<p>It diminishes the effectiveness of vaccines and diagnostics, potentially requiring frequent updates. (C)</p> Signup and view all the answers

What is the primary implication of fomites in the context of disease transmission?

<p>They can carry pathogens and facilitate indirect transmission to new hosts. (D)</p> Signup and view all the answers

What role does 'immunosuppression' play in environmental challenges faced by an agent within a host?

<p>It allows the agent to persist within the host by evading immune detection and clearance. (B)</p> Signup and view all the answers

In the context of veterinary epidemiology, what does 'association' refer to, and how does it differ from 'causation'?

<p>Association is a statistical correlation between two variables without necessarily implying a cause-and-effect relationship, whereas causation implies a direct relationship where one variable causes the other. (B)</p> Signup and view all the answers

What is the significance of considering 'confounding factors' when analyzing associations between exposures and outcomes in epidemiological studies?

<p>Confounding factors can distort the apparent relationship between an exposure and an outcome, leading to spurious conclusions. (C)</p> Signup and view all the answers

What is the primary focus when applying epidemiological principles to non-infectious diseases?

<p>Identifying environmental exposures, genetic predispositions, and lifestyle factors that contribute to disease development. (A)</p> Signup and view all the answers

What critical role do veterinary practitioners play in epidemiology?

<p>Veterinary practitioners can serve as front-line observers, collecting crucial data and identifying early signs of disease outbreaks. (D)</p> Signup and view all the answers

What should a veterinary practitioner do if they are unable to attend a mandatory tutorial?

<p>Apply for and have Special Considerations approved. (D)</p> Signup and view all the answers

What is the rationale for requiring students with Student Access Plans (SAPs) to request support two weeks before each quiz?

<p>To ensure accommodations are properly arranged and students receive appropriate support. (B)</p> Signup and view all the answers

When constructing a clinical research question for Assessment Item 2, what skills do the students primarily develop?

<p>Skills needed for evidence-based veterinary medicine. (D)</p> Signup and view all the answers

When will the interactive oral approach be discussed?

<p>The interactive oral approach will be discussed throughout the semester. (C)</p> Signup and view all the answers

In terms of the determinants of disease, what characterizes the agent?

<p>Infectivity, pathogenicity, virulence, immunogenicity, antigenic variation, survival (A)</p> Signup and view all the answers

In the context of Modes of Transmission, what statement is correct?

<p>In Vertical Transmission, agents are transmitted with the genome of parents. (C)</p> Signup and view all the answers

How do environmental conditions influence agent survival and transmission in epidemiological studies?

<p>Environmental conditions such as temperature, desiccation, and UV light can significantly affect the survival and transmission of agents. (C)</p> Signup and view all the answers

What strategies do agents employ to respond to host challenges?

<p>Employ features such as capsules, and/or have intracellular life. (A)</p> Signup and view all the answers

In the context of horizontal transmission of infectious agents, which of the following statements is the most accurate regarding routes of infection?

<p>Oral, skin/cornea/mucous membranes, long distance movement, vector mobility and percutaneous are routes of infection. (B)</p> Signup and view all the answers

In regards to disease transmission, what would be a fomite?

<p>Trucks. (A)</p> Signup and view all the answers

When might vertical/venereal/vector transmission be avoided?

<p>Environmental challenges. (E)</p> Signup and view all the answers

Within the context of what we've discussed, what statement is incorrect?

<p>Veterinary epidemiology is primarily concerned with understanding and controlling diseases in animal populations, it does not extend to effects on human populations. (D)</p> Signup and view all the answers

What is a primary goal of monitoring and evaluating disease control programmes in veterinary epidemiology?

<p>To assess the effectiveness of interventions and adapt strategies to optimize outcomes. (C)</p> Signup and view all the answers

In Epidemiology, how far does the study of disease extend to?

<p>Both infectious and non-infectious diseases. (C)</p> Signup and view all the answers

In the spectrum of an infectious disease, what signifies the end of the 'incubabtion period'?

<p>When the first clinical signs are observed. (C)</p> Signup and view all the answers

If an infectious agent has a high 'immunogenicity', what impact do you think/assume this will have on a host population?

<p>The host population would be likely to mount a strong inflammatory response. (B)</p> Signup and view all the answers

Transmission of a pathogen typically involves which three elements?

<p>Agent, host, and environment. (B)</p> Signup and view all the answers

What is the best definition of a 'reservoir'?

<p>Where agent normally lives and replicates (A)</p> Signup and view all the answers

Which best describes the term 'Dead-end'?

<p>Dead-end - cannot transmit agent to another animal (A)</p> Signup and view all the answers

How does veterinary epidemiology support the sustainable development goals?

<p>Veterinary epidemiology promotes multiple objectives, including supporting food security and safety and building planet health and biodiversity. (D)</p> Signup and view all the answers

In the context of infection from a vector, what is a biological vector?

<p>Where the infective agent undergoes biological changes. (C)</p> Signup and view all the answers

How does 'extension of host range' assist in environmental challenges for an agent?

<p>Can cause transmission to unrelated species. (B)</p> Signup and view all the answers

Which of the following is the best description of 'mechanical vector'?

<p>A physical carrier of the agent. (C)</p> Signup and view all the answers

Why are the 'Sustainable Development Goals' aligned with veterinary epidemiology?

<p>Both aim to promote health and biodiversity. (C)</p> Signup and view all the answers

In a disease outbreak investigation, if initial data suggests a common source but varying levels of infection severity, which determinant of disease should be evaluated first to understand these variations?

<p>Host factors, focusing on pre-existing conditions and immune status. (B)</p> Signup and view all the answers

What is the key distinction between 'association' and 'causation' in epidemiological inference, and why is it crucial to differentiate between them for effective veterinary interventions?

<p>Association implies a correlational relationship, while causation demonstrates a direct mechanistic link, which is vital for targeted disease control. (D)</p> Signup and view all the answers

How does the concept of 'herd immunity' relate to and modify the traditional epidemiological triad (agent, host, environment) in the context of a highly contagious disease?

<p>It alters the 'host' component by creating a subset of immune individuals, thus disrupting transmission and protecting vulnerable populations. (B)</p> Signup and view all the answers

In the context of disease transmission, what critical factor distinguishes a 'biological vector' from a 'mechanical vector', influencing the complexity of disease control strategies?

<p>Biological vectors are integral for agent replication or development, while mechanical vectors are passive transporters, impacting transmission dynamics. (B)</p> Signup and view all the answers

What is the most significant implication of 'antigenic variation' in the context of long-term disease management and control in veterinary populations?

<p>It necessitates frequent reformulation of vaccines, requiring continuous surveillance and adaptation of immunization strategies. (D)</p> Signup and view all the answers

How might a veterinary epidemiologist apply the principles of epidemiology to address and mitigate the impact of a non-infectious disease, such as chronic laminitis in a dairy herd?

<p>By analyzing environmental and management factors contributing to the disease, such as nutrition and housing, to guide preventive strategies. (B)</p> Signup and view all the answers

In the context of the 'agent' component of the epidemiological triad, what is the key difference between 'infectivity' and 'pathogenicity', and how do these characteristics independently influence disease dynamics?

<p>'Infectivity' is the capacity of an agent to establish an infection, while 'pathogenicity' is its ability to cause disease once infection has occurred, impacting disease spread and severity differently. (B)</p> Signup and view all the answers

Considering the role of 'fomites' in disease transmission, under what circumstances would eliminating fomites have the LEAST impact on controlling the spread of a highly contagious viral disease within a livestock population?

<p>When the disease is primarily transmitted through direct contact and aerosol routes, with minimal environmental persistence of the virus. (A)</p> Signup and view all the answers

In the study of veterinary epidemiology, what critical refinement does the concept of the 'latent period' introduce to our understanding of infectious disease dynamics, beyond what is captured by the 'incubation period' alone?

<p>The 'latent period' identifies when an individual is infectious irrespective of showing clinical signs, crucial for controlling subclinical spread. (B)</p> Signup and view all the answers

In the context of disease prevention and control, which strategy would be considered the MOST proactive application of veterinary epidemiology principles?

<p>Implementing routine vaccination programs based on continuous risk assessment and surveillance data. (A)</p> Signup and view all the answers

Flashcards

What is Epidemiology?

The study of disease in populations. It examines the distribution, determinants, and control of diseases and health conditions in defined populations.

Objectives of Veterinary Epidemiology?

Determination of the origin of a disease, investigation and control of diseases, gathering info on disease ecology, assessing economic/social impacts, developing/monitoring control programs.

Determinants of disease

Factors (agent, host, environment) that influence the occurrence and spread of diseases in populations.

Host(in epidemiology)

An animal capable of being infected by an infectious agent.

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Latent period

The time from infection to the point when an individual becomes infectious.

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Incubation period

The period from infection until clinical signs appear.

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Infectious period

The time when an infected individual can transmit an infectious agent to others.

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Transmission of disease

The ways infectious agents spread -- direct contact, airborne transmission, vectors, or vehicles.

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Modes of transmission

Direct or indirect.

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Chain of infection

Agent leaves infected host through exit portals and infects new hosts at entry portals.

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Vertical transmission

Hereditary or congenital.

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Causation

The relationship between a cause and its effect. The degree or dependence between two variables.

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Association

The degree of dependence between two variables.

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Confounding

An apparent association between an exposure and an outcome that is due to another factor, which is related to both the exposure and the outcome.

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Study Notes

VSC329 Week 1 Overview

  • The week 1 introduction provides an overview of the VSC329 course.
  • Details of course subject matter, expectations, and ways to find key information.
  • Defines the scope and objectives of epidemiology.
  • Classifies epidemiological concepts and relationships including the epidemiology triad.
  • Introduces causality, association, and confounding.
  • Details infectious disease concepts focusing on latent periods.
  • Discusses disease transmission and maintenance.
  • Includes the role of epidemiology in non-infectious diseases.

Weekly Schedule and Expectations

  • Each week involves preparation through readings, videos and thinking.
  • Participation includes Wednesday sessions from 3-5pm.
  • Participation in check-ins, linking concepts, case studies, and possible Zoom lectures.
  • In-class and self-directed recap activities for up to 5 hours.
  • Timetabled sessions occur Fridays 9-11 and 11-1.
  • Check individual timetables for specific room and time details.
  • There's no tutorial in Week 8 due to Anzac Day on April 25th.
  • Week 14 will have a whole class session on June 6th from 9am.

Epidemiology

  • The study of disease in populations.
  • All vets in clinical practice may have involvement in epidemiology.
  • Determination of a disease's origin when its cause is known.
  • Investigation and control of diseases with unknown or poorly understood causes.
  • Collection of data on a disease's ecology or natural history.
  • Assesses the economic, social, and welfare impacts of diseases.
  • Developing, monitoring, and evaluating disease control programs.
  • Goal is evidenced-based interventions to reduce animal and human suffering.
  • Improves food security and safety.
  • Strengthens planet health and biodiversity, emphasizing prevention.

Determinants of Disease: Factors that Impact Disease

  • Epidemiology studies the relationships between agent, host, and environment.
  • Host factors include the animal capable of being infected by an infectious agent.
  • Host types include possible dead-end organisms that cannot transmit to other animals.
  • Also includes reservoirs that are able to maintain and replicate the agent.
  • Characteristics that impact disease spread include susceptibility and infectiousness.
  • Infectiousness considerations include the duration of the infectious period, and the amount of agent transmitted from host.
  • Agent factors include infectivity, pathogenicity, virulence, immunogenicity and antigenic variation.
  • Environmental elements such as climate/weather, water systems, water quality, food, and geology are taken into account.

Important Concepts of Infectious Disease

  • Disease spectrum in an individual over time can be described by:
    • Incubation period
    • Latent period
    • Infectious period.
  • Latent period: time from infection to becoming infectious.
  • Incubation period: time from infection to presentation of clinical signs.
  • Infectious period: when the agent can be transmitted from an infected individual.
  • The relationship between these periods varies based on agent and individual.

Maintenance and Transmission

  • Involves routes determining how an agent leaves an infected host and enters a new one.
  • Horizontal transmission includes direct contact, contact with discharges, or cannibalism.
  • Vertical transmission passes through egg or sperm.
  • Examples of vertical transmission events include the agent being transmitted with parental genomes.
  • Can be congenital, present at birth or acquired.
  • Horizontal indirect transmission animate vectors, or inanimate carriers are required.
  • Environmental transmission occurs through air.

Causation vs Association

  • Causation is the relationship between cause and effect.
  • Association is the degree of dependence between two variables.
  • Confounding as mixing of associations or apparent association.
  • Exposure and outcome that is due to another related factor affecting both the exposure and the outcome..

Non-Infectious Disease

  • Epidemiology also addresses non-communicable diseases.
  • Accumulation of lifetime exposures examined.
  • Factors considered are congenital, respiratory, musculoskeletal, dermatologic and genitourinary.

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