Pneumonia and Pulmonary Infections
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Questions and Answers

Which presentation is LEAST likely to be observed in an elderly patient with pneumonia?

  • Tachypnea
  • Productive cough (correct)
  • Confusion
  • Hypothermia

A patient with a history of alcoholism presents with pneumonia and 'current jelly sputum'. Which pathogen is MOST likely responsible?

  • Moraxella catarrhalis
  • Klebsiella pneumoniae (correct)
  • Haemophilus influenzae
  • Streptococcus pneumoniae

Which of the following pathogens is LEAST likely to be implicated in hospital-acquired pneumonia?

  • Oral anaerobes
  • Pseudomonas aeruginosa
  • Streptococcus pneumoniae (correct)
  • Staphylococcus aureus

A patient who recently traveled to the southwestern United States presents with pneumonia. Which organism should be HIGHLY suspected?

<p>Coccidioides spp. (A)</p> Signup and view all the answers

Following a recent influenza infection, a patient develops a secondary pneumonia. Which pathogen is MOST likely responsible for this complication?

<p>Staphylococcus aureus (B)</p> Signup and view all the answers

Which of the following is the MOST likely route of infection in a patient diagnosed with community-acquired pneumonia (CAP)?

<p>Inhalation of infectious airborne particles. (C)</p> Signup and view all the answers

A patient with bronchiectasis develops pneumonia. Which of the following is the MOST likely causative agent?

<p>Pseudomonas aeruginosa (B)</p> Signup and view all the answers

A patient with a history of exposure to bird droppings presents with respiratory symptoms. Infection with which of the following organisms is MOST likely?

<p>Histoplasma capsulatum (C)</p> Signup and view all the answers

A patient presents with a chronic cough, purulent sputum production and hemoptysis. High-resolution CT imaging reveals bronchial dilation and airway wall thickening. Which condition is MOST consistent with these findings?

<p>Bronchiectasis (C)</p> Signup and view all the answers

Which of the following is NOT typically included in the initial management of acute bronchitis?

<p>Antibiotics (C)</p> Signup and view all the answers

Which of the following scenarios presents the HIGHEST risk for pneumonia caused by mixed aerobic and anaerobic organisms?

<p>Aspiration event (B)</p> Signup and view all the answers

In a patient who develops pneumonia while hospitalized, which of the following pathogens would be LEAST likely?

<p>Streptococcus pneumoniae (B)</p> Signup and view all the answers

Which mechanism underlies pneumonia development secondary to aspiration?

<p>Compromised pulmonary defense mechanisms (C)</p> Signup and view all the answers

A patient with AIDS presents with dyspnea, fever, and a dry cough with hypoxemia out of proportion. What pulmonary infection is MOST likely?

<p>Pneumocystis jirovecii pneumonia (PCP) (A)</p> Signup and view all the answers

A farmer presents with fever, chills, a non-productive cough, and myalgias after assisting with the birthing of lambs. Which pulmonary infection should be suspected?

<p>Q fever (Coxiella burnetii) (D)</p> Signup and view all the answers

In the context of pneumonia, if a patient is described as having decreased 'cellular and humoral immune response,' which pathogenic mechanism is MOST likely to be implicated?

<p>Compromised pulmonary defense (D)</p> Signup and view all the answers

A patient presents with a cough productive of red currant jelly sputum. Which organism is classically associated with this presentation?

<p>Klebsiella pneumoniae (A)</p> Signup and view all the answers

Which of the following physical exam findings would be LEAST likely in a patient with typical pneumonia?

<p>Mental confusion (B)</p> Signup and view all the answers

A patient who recently stayed at a hotel presents with pneumonia, accompanied by gastrointestinal symptoms, headache, and CNS symptoms. Which pathogen is MOST likely responsible?

<p>Legionella spp (D)</p> Signup and view all the answers

Following a bioterrorism event, several individuals develop pneumonia. Radiographic analysis reveals mediastinal widening without infiltrates. Which pathogen is MOST likely responsible?

<p>Bacillus anthracis (C)</p> Signup and view all the answers

Which radiographic pattern is LEAST likely to be associated with viral pneumonia?

<p>Focal infiltrate (D)</p> Signup and view all the answers

A patient presents with atypical pneumonia. Which of the following symptoms, if present, would MOST strongly suggest psittacosis?

<p>Horder spots (C)</p> Signup and view all the answers

A patient presents with pneumonia and foul-smelling sputum. Which type of infection is MOST likely?

<p>Anaerobic infection (B)</p> Signup and view all the answers

A patient is suspected of having early-stage community-acquired pneumonia (CAP), but the initial chest radiograph (CXR) is negative. What is the MOST appropriate next step in management?

<p>Repeat CXR within 24 hours (B)</p> Signup and view all the answers

Which finding is LEAST likely to be associated with typical pneumonia caused by Haemophilus influenzae?

<p>Subtle pulmonary infiltrates (A)</p> Signup and view all the answers

Which of the following viruses is typically associated with 'atypical' pneumonia?

<p>Respiratory syncytial virus (A)</p> Signup and view all the answers

A patient presents with pneumonia, diarrhea, and otalgia. Which pathogen is LEAST likely to be the cause?

<p><em>Moraxella catarrhalis</em> (A)</p> Signup and view all the answers

During influenza season, which rapid molecular assay is recommended as part of the initial diagnostic testing for Community-Acquired Pneumonia (CAP)?

<p>Influenza molecular assay (D)</p> Signup and view all the answers

Which of the following is NOT typically part of the initial standard diagnostic tests for Community-Acquired Pneumonia (CAP)?

<p>Sputum Gram stain and culture (D)</p> Signup and view all the answers

Which characteristic clinical presentation differentiates 'atypical' pneumonia from typical pneumonia?

<p>Non-lobar infiltrates and extrapulmonary manifestations (D)</p> Signup and view all the answers

The presence of which finding would most strongly suggest a diagnosis of typical pneumonia rather than atypical pneumonia?

<p>Lobar consolidation on chest radiograph (A)</p> Signup and view all the answers

Under what condition is lactic acid level testing specifically recommended in patients with suspected Community-Acquired Pneumonia (CAP)?

<p>In patients with suspected sepsis (C)</p> Signup and view all the answers

A Gram stain reveals gram-negative encapsulated bacilli. Which organism is MOST likely the causative agent?

<p>Klebsiella pneumoniae (C)</p> Signup and view all the answers

In a patient presenting with subacute pneumonia and a history of exposure to birds, which pathogen should be HIGHLY suspected?

<p><em>Chlamydophila psittaci</em> (C)</p> Signup and view all the answers

Which of the following is a characteristic pulmonary finding associated with typical pneumonia?

<p>Egophony detected during auscultation (C)</p> Signup and view all the answers

Which diagnostic method is LEAST effective for directly identifying Mycoplasma pneumoniae?

<p>Gram staining (C)</p> Signup and view all the answers

A previously healthy 25-year-old presents with a two-week history of dry cough, headache, and fatigue, followed by the insidious onset of dyspnea. Auscultation reveals scattered rhonchi, and chest X-ray shows bilateral, patchy infiltrates. Sputum Gram stain is negative for bacteria. Which of the following pathogens is the MOST likely cause?

<p><em>Mycoplasma pneumoniae</em> (D)</p> Signup and view all the answers

Which of the following scenarios would MOST warrant a bronchoscopy with bronchoalveolar lavage in a patient diagnosed with pneumonia?

<p>Patient is deteriorating despite broad-spectrum antibiotics, and no definitive pathogen has been identified. (A)</p> Signup and view all the answers

A patient's Gram stain shows gram-negative diplococci. Which of the following organisms is the MOST likely cause?

<p>Moraxella catarrhalis (B)</p> Signup and view all the answers

In the context of pneumonia diagnostics, what is the PRIMARY rationale for measuring procalcitonin and C-reactive protein (CRP), despite their controversial nature?

<p>To potentially identify patients at a higher risk of adverse outcomes. (A)</p> Signup and view all the answers

Which of the following auscultatory findings is LEAST consistent with typical pneumonia, particularly in the context of lobar consolidation?

<p>Normal vesicular breath sounds (C)</p> Signup and view all the answers

A patient presents with pneumonia, and lab results identify gram-negative coccobacilli. Which organism is MOST likely responsible?

<p><code>Haemophilus influenzae</code> (D)</p> Signup and view all the answers

A patient with pneumonia also exhibits gastrointestinal symptoms and neurological signs. Which of the following pathogens is MOST likely responsible?

<p><code>Legionella pneumophila</code> (A)</p> Signup and view all the answers

Which of the following viral pathogens is LEAST likely to cause 'atypical' pneumonia with nonlobar infiltrates?

<p><code>Streptococcus pneumoniae</code> (D)</p> Signup and view all the answers

A patient presents with pneumonia following exposure to birds, specifically parrots at home. Which of the following is the MOST likely causative agent?

<p><code>Chlamydophila psittaci</code> (A)</p> Signup and view all the answers

In the context of atypical pneumonia, which characteristic is LEAST likely?

<p>Abrupt onset of high fever and productive cough (C)</p> Signup and view all the answers

Which of the following findings on Gram stain MOST strongly suggests Klebsiella pneumoniae as the causative agent of pneumonia?

<p>Gram-negative encapsulated bacilli (D)</p> Signup and view all the answers

A patient with severe CAP is not improving despite broad-spectrum antibiotics. Initial sputum Gram stain was inconclusive. Which test would provide the MOST rapid and specific identification of a potential viral etiology?

<p>Polymerase chain reaction (PCR) testing (C)</p> Signup and view all the answers

A patient presents with suspected Legionella pneumonia. Which unique laboratory finding, though not always present, would provide the STRONGEST supportive evidence for this diagnosis?

<p>Hyponatremia (C)</p> Signup and view all the answers

A previously healthy adult presents with subacute pneumonia. Initial investigations are unrevealing. Flexible bronchoscopy with bronchoalveolar lavage (BAL) is performed, and the sample undergoes metagenomic next-generation sequencing (mNGS). The mNGS reveals a high abundance of viral sequences, but standard viral PCR is negative. Which pathogen is MOST likely responsible?

<p>Previously unrecognized strain of Human Coronavirus (C)</p> Signup and view all the answers

In the context of pneumonia diagnosis, what is the PRIMARY utility of measuring procalcitonin levels?

<p>To identify patients at risk for worse outcomes (C)</p> Signup and view all the answers

If a patient presents with pneumonia and a diagnostic workup is initiated, during which season would a rapid influenza molecular assay be MOST critical as part of the initial diagnostic evaluation?

<p>Influenza season (A)</p> Signup and view all the answers

Which of the following historical factors is MOST likely to predispose a patient to pneumonia caused by a combination of aerobic and anaerobic organisms?

<p>Aspiration (C)</p> Signup and view all the answers

A patient with a known history of COPD is admitted to the hospital with community-acquired pneumonia (CAP). Which of the following organisms is LEAST likely to be the causative agent?

<p>Coccidioides immitis (A)</p> Signup and view all the answers

Which Gram stain result is MOST consistent with Moraxella catarrhalis?

<p>Gram-negative diplococci (B)</p> Signup and view all the answers

A patient presents with pneumonia, and initial tests are inconclusive. The patient deteriorates despite broad-spectrum antibiotics. Which invasive diagnostic procedure is MOST appropriate to identify the causative pathogen if less invasive methods have failed?

<p>Bronchoscopy with bronchoalveolar lavage (B)</p> Signup and view all the answers

A patient with a history of frequent antibiotic use develops pneumonia. Which pathogen should be of HIGHEST concern due to its resistance profile?

<p>Methicillin-resistant Staphylococcus aureus (MRSA) (D)</p> Signup and view all the answers

Which of the following conditions is LEAST associated with an increased incidence of gram-negative bacteria in pneumonia?

<p>Recent travel to the Southwestern United States (D)</p> Signup and view all the answers

A patient who is suspected of having pneumonia tests negative on a sputum Gram stain. All of the following serology tests require a paired sample EXCEPT:

<p><em>Legionella</em> serology (urinary antigen) (B)</p> Signup and view all the answers

What is the MOST appropriate course of action regarding antibiotic therapy and further diagnostic testing in a patient diagnosed with CAP, demonstrating clinical improvement with appropriate antibiotics, and yielding a sputum Gram stain revealing no predominant organism?

<p>Continue current antibiotic regimen; no additional diagnostic testing is needed. (B)</p> Signup and view all the answers

Which clinical manifestation is MOST indicative of pneumonia caused by Legionella species rather than other common bacterial pathogens?

<p>Confusion and diarrhea (B)</p> Signup and view all the answers

A patient presents with pneumonia and a diffuse maculopapular rash. Which of the following underlying conditions would MOST strongly suggest Mycoplasma pneumoniae as the causative agent?

<p>None of these options (C)</p> Signup and view all the answers

A patient who works in construction in Arizona presents with pneumonia, arthralgia and painful skin nodules that resemble erythema nodosum. Which of the following is the MOST likely causative organism?

<p>Coccidioides immitis (A)</p> Signup and view all the answers

Which of the following pathogens is LEAST likely to cause pneumonia in a patient with advanced HIV infection and a CD4 count below 50 cells/µL?

<p>Moraxella catarrhalis (D)</p> Signup and view all the answers

After suspected exposure to a bioweapon, several patients present with pneumonia, and chest radiographs reveal a widened mediastinum without infiltrates. Which of the following mechanisms is MOST directly causative of the mediastinal widening?

<p>Lymphatic drainage impairment causing massive mediastinal lymphadenopathy. (D)</p> Signup and view all the answers

A patient presents with pneumonia, and the Gram stain of their sputum reveals encapsulated gram-negative bacilli. Which virulence factor is MOST likely contributing to the pathogenesis of this infection?

<p>Capsular polysaccharide, impairing phagocytosis. (D)</p> Signup and view all the answers

A patient with suspected pneumonia is noted to have significant pleuritic chest pain, and auscultation reveals a pleural friction rub over the affected area. Which of the following pathological processes is MOST directly contributing to these findings?

<p>Inflammation of the pleura, causing friction during respiration. (A)</p> Signup and view all the answers

A patient presents with pneumonia. Sputum culture grows Klebsiella pneumoniae. Which description is MOST consistent with the expected appearance of the patient's sputum?

<p>Thick and red, resembling currant jelly. (B)</p> Signup and view all the answers

A patient who recently returned from a cruise presents with pneumonia accompanied by gastrointestinal symptoms and confusion. Which of the following mechanisms is MOST likely implicated in the pathogenesis of disease?

<p>Intracellular replication within alveolar macrophages. (C)</p> Signup and view all the answers

A patient presents to the emergency department in early winter with a 3-day history of cough, fever, and malaise. A rapid influenza test is negative. Chest X-ray shows patchy infiltrates. Which of the following pathogens is LEAST likely to be the causative agent of pneumonia in this scenario?

<p><em>Streptococcus pneumoniae</em>. (A)</p> Signup and view all the answers

A homeless patient with a history of chronic alcohol abuse is brought to the ED with cough, fever, and shortness of breath. His sputum is thick, bloody, and has a 'red currant jelly' appearance. Besides pneumonia, which of the following conditions should be HIGHLY suspected in this patient?

<p>Lung abscess due to aspiration of oral flora. (C)</p> Signup and view all the answers

A patient is admitted to the ICU with severe community-acquired pneumonia (CAP). Despite appropriate antibiotic therapy, the patient develops septic shock and acute respiratory distress syndrome (ARDS). Which of the following pathophysiologic mechanisms is MOST likely driving the development of ARDS in this patient?

<p>Exaggerated host inflammatory response leading to diffuse alveolar damage. (D)</p> Signup and view all the answers

Which of the following defense mechanism failures is MOST likely to predispose a patient to pneumonia following aspiration of gastric contents?

<p>Suppressed cough reflex (A)</p> Signup and view all the answers

A researcher is investigating novel therapies for pneumonia caused by Streptococcus pneumoniae. Which of the following approaches would be MOST likely to directly target a virulence factor SPECIFIC to this pathogen, rather than a general antibacterial mechanism?

<p>Blocking capsule formation (B)</p> Signup and view all the answers

A patient with a history of chronic obstructive pulmonary disease (COPD) is admitted to the hospital with a diagnosis of community-acquired pneumonia (CAP). Which of the following pathogens is LEAST likely to be the causative agent, assuming no other risk factors are present?

<p><em>Mycoplasma pneumoniae</em> (B)</p> Signup and view all the answers

In the context of hospital-acquired pneumonia, which measure is MOST effective in preventing the spread of infection and reducing the incidence of new cases?

<p>Strict adherence to hand hygiene protocols by healthcare workers (B)</p> Signup and view all the answers

You are evaluating a patient with suspected pneumonia. Their chest X-ray shows patchy infiltrates primarily in the lower lobes. Which of the following historical clues would MOST strongly suggest aspiration pneumonia as the underlying cause?

<p>History of a witnessed seizure followed by coughing (A)</p> Signup and view all the answers

Which of the following is the MOST critical distinction between the etiologies and treatment strategies of community-acquired pneumonia (CAP) and hospital-acquired pneumonia (HAP)?

<p>HAP is more likely to involve multi-drug resistant organisms (A)</p> Signup and view all the answers

A patient with AIDS presents with dyspnea, fever, and a dry cough. A diagnostic test reveals elevated levels of 1,3-beta-D-glucan in their serum. Which of the following organisms is the MOST likely cause of their pneumonia?

<p><em>Pneumocystis jirovecii</em> (A)</p> Signup and view all the answers

Consider a hypothetical scenario: Researchers develop a novel drug that selectively enhances the activity of pulmonary alveolar macrophages. In the context of pneumonia prevention, which of the following mechanisms would MOST directly contribute to the drug's protective effect?

<p>Enhanced opsonization of bacterial pathogens, facilitating phagocytosis. (B)</p> Signup and view all the answers

A patient presents with pneumonia characterized by 'rusty brown sputum'. Which bacterial structure is MOST likely contributing directly to the sputum's color?

<p>Capsular polysaccharides binding to iron molecules in the lungs. (D)</p> Signup and view all the answers

Which characteristic of Staphylococcus aureus makes it a greater concern in hospital-acquired pneumonia compared to community-acquired pneumonia?

<p>Its propensity to form biofilms on implanted medical devices. (A)</p> Signup and view all the answers

In a patient with a history of alcohol abuse and presenting with pneumonia, which virulence factor of Klebsiella pneumoniae MOST directly contributes to its ability to cause extensive lung damage and necrosis?

<p>The capsule, inhibiting phagocytosis and complement binding. (C)</p> Signup and view all the answers

A cystic fibrosis (CF) patient on chronic antibiotics develops pneumonia. Sputum cultures grow Pseudomonas aeruginosa. Which bacterial adaptation is MOST likely confounding treatment efficacy?

<p>Formation of alginate biofilms, reducing antibiotic penetration. (D)</p> Signup and view all the answers

Why is differentiation between Haemophilus influenzae and Moraxella catarrhalis etiologies important in COPD patients presenting with pneumonia, despite both being Gram-negative organisms commonly associated with COPD exacerbations?

<p><em>M. catarrhalis</em> frequently produces beta-lactamases, leading to ampicillin resistance. (A)</p> Signup and view all the answers

Which organism is characterized as Gram-positive diplococci and is the most common cause of community-acquired pneumonia?

<p>Streptococcus pneumoniae (C)</p> Signup and view all the answers

In which patient population is Staphylococcus aureus pneumonia MOST commonly observed?

<p>Nursing home residents, hospitalized patients, IV drug users, and those post-influenzae (D)</p> Signup and view all the answers

Which of the following organisms associated with pneumonia is a gram-negative encapsulated rod, often seen in patients with ETOH abuse, DM, or hospital-acquired infections?

<p>Klebsiella pneumoniae (A)</p> Signup and view all the answers

A patient with cystic fibrosis develops pneumonia. Which Gram-negative organism is MOST likely the causative agent?

<p>Pseudomonas aeruginosa (B)</p> Signup and view all the answers

Differentiate between Haemophilus influenzae and Moraxella catarrhalis based on their microscopic morphology.

<p><em>Haemophilus influenzae</em> are Gram-negative coccobacilli, while <em>Moraxella catarrhalis</em> are Gram-negative diplococci. (A)</p> Signup and view all the answers

In the context of hospital-acquired pneumonia, which of the following bacterial pathogens is MOST frequently implicated?

<p><em>Pseudomonas aeruginosa</em> (C)</p> Signup and view all the answers

A patient with a history of Chronic Obstructive Pulmonary Disease (COPD) presents with pneumonia. Based on their medical history, which of the following pathogens is MOST likely to be the causative agent?

<p><em>Haemophilus influenzae</em> (C)</p> Signup and view all the answers

A patient with a history of chronic alcoholism is admitted with pneumonia and is producing 'current jelly sputum'. Which of the following organisms should be HIGHLY suspected as the causative agent?

<p><em>Klebsiella pneumoniae</em> (C)</p> Signup and view all the answers

Which of the following clinical presentations would be considered the LEAST typical in an elderly patient experiencing pneumonia?

<p>Productive cough (A)</p> Signup and view all the answers

A patient who owns a pet parrot develops pneumonia. Which of the following pathogens is MOST strongly associated with bird exposure and should be considered in the differential diagnosis?

<p><em>Chlamydia psittaci</em> (C)</p> Signup and view all the answers

Among the atypical pneumonia pathogens, which of the following is specifically known to be associated with confusion and diarrhea as extra-pulmonary symptoms?

<p><em>Legionella pneumophila</em> (D)</p> Signup and view all the answers

A patient who recently traveled to Arizona and New Mexico presents with pneumonia. Which of the following fungal pathogens is MOST likely responsible, given the patient's travel history to the southwestern United States?

<p><em>Coccidioides immitis</em> (B)</p> Signup and view all the answers

Consider a patient with bronchiectasis who develops pneumonia. While Pseudomonas aeruginosa is commonly associated with bronchiectasis, which of the following scenarios would make Staphylococcus aureus a MORE likely causative agent in this specific patient?

<p>The patient has recently completed a course of antibiotics targeting gram-negative bacteria. (A)</p> Signup and view all the answers

Which of the following is the MOST common etiology of acute bronchitis?

<p>Viral infection (C)</p> Signup and view all the answers

According to the provided information, which of the following is a typical sign or symptom of acute bronchitis?

<p>Scattered rhonchi and wheezing (D)</p> Signup and view all the answers

Pneumonia is defined as an infection affecting which specific part of the respiratory system?

<p>The lung parenchyma (A)</p> Signup and view all the answers

Which of the following patient populations is described as being at a particularly high risk of death from pneumonia, according to the content provided?

<p>Older adults with chronic diseases (D)</p> Signup and view all the answers

Which of the following is a characteristic pulmonary finding commonly associated with pneumonia caused by Haemophilus influenzae?

<p>Lobar consolidation with bronchial breath sounds (A)</p> Signup and view all the answers

A patient presents with pneumonia but exhibits minimal respiratory symptoms, nonlobar infiltrates on chest radiography, and diarrhea. Which pathogen is MOST likely responsible?

<p><em>Mycoplasma pneumoniae</em> (B)</p> Signup and view all the answers

Among the mechanisms listed for the pathophysiology of pneumonia, which of the following is described as the MOST common?

<p>Inhalation of infectious particles (A)</p> Signup and view all the answers

Which of the following mechanisms of pneumonia development is LEAST likely to occur in an immunocompetent individual?

<p>Re-activation of latent infection (C)</p> Signup and view all the answers

Which respiratory virus is LEAST likely to be associated with 'atypical' pneumonia?

<p>Human herpesvirus 6 (A)</p> Signup and view all the answers

The classic presentation of 'typical' community-acquired pneumonia (CAP) is characterized by several findings. Which of the following is LEAST consistent with this 'typical' presentation?

<p>Gradual onset of dry cough (B)</p> Signup and view all the answers

Which of the following pathogens is MOST likely to cause pneumonia with prominent gastrointestinal symptoms, like diarrhea, in addition to respiratory symptoms?

<p><em>Mycoplasma pneumoniae</em> (D)</p> Signup and view all the answers

Considering the 'typical' CAP pathogens and presentation described, which of the following pathogens is MOST likely to be associated with 'typical' community-acquired pneumonia?

<p><em>Streptococcus pneumoniae</em> (B)</p> Signup and view all the answers

A patient presents with pneumonia and a history of recent exposure to birds. Which of the following pathogens should be HIGHLY suspected in this case?

<p><em>Chlamydophila psittaci</em> (C)</p> Signup and view all the answers

Which of the following pathogens is LEAST likely to be identified using a Gram stain of sputum?

<p><em>Mycoplasma pneumoniae</em> (D)</p> Signup and view all the answers

In a patient presenting with subacute pneumonia, which of the following viruses is LEAST likely to be causative?

<p>Varicella-zoster virus (D)</p> Signup and view all the answers

A previously healthy individual develops pneumonia following a recent upper respiratory infection characterized by coryza and mild pharyngitis. Radiography shows bilateral, patchy infiltrates. If initial bacterial cultures are negative, which viral etiology is LEAST likely?

<p>Epstein-Barr Virus (A)</p> Signup and view all the answers

Which sputum characteristic is MOST classically associated with Klebsiella pneumoniae pneumonia?

<p>Red currant jelly (C)</p> Signup and view all the answers

A cough lasting longer than two weeks accompanied by whooping sounds or posttussive vomiting is MOST suggestive of pneumonia caused by which organism?

<p>Bordetella pertussis (B)</p> Signup and view all the answers

A patient presents with pneumonia and is noted to have mental confusion. This symptom is MORE characteristic of which type of pneumonia?

<p>Atypical pneumonia (D)</p> Signup and view all the answers

Interstitial infiltrates observed on a chest X-ray of a patient with pneumonia are MOST suggestive of which etiological category?

<p>Viral (D)</p> Signup and view all the answers

A traveler returning from a cruise ship presents with pneumonia, gastrointestinal distress, and headache. Which pathogen is MOST likely responsible?

<p>Legionella spp (D)</p> Signup and view all the answers

A chest X-ray of a patient with pneumonia reveals mediastinal widening but no pulmonary infiltrates. Which specific pathogen is MOST strongly indicated by this radiographic finding?

<p>Bacillus anthracis (D)</p> Signup and view all the answers

Green sputum can be observed in pneumonia caused by several pathogens. However, it is LEAST characteristic of pneumonia caused by which of the following organisms listed in the provided text?

<p>Klebsiella pneumoniae (C)</p> Signup and view all the answers

While bronchial breath sounds are a typical finding in pneumonia, in which scenario within the spectrum of pneumonia presentation are they LEAST likely to be prominent or detectable?

<p>Early stage community-acquired pneumonia with negative initial CXR (D)</p> Signup and view all the answers

During which scenario would a sputum Gram stain and culture be MOST critical for guiding pneumonia treatment?

<p>A patient with suspected aspiration pneumonia and a history of antibiotic resistance. (A)</p> Signup and view all the answers

What is the expected Gram stain morphology for Moraxella catarrhalis?

<p>Gram-negative diplococci. (B)</p> Signup and view all the answers

Which diagnostic method for pneumonia involves direct examination of the lower respiratory tract and specimen collection?

<p>Bronchoscopy with bronchoalveolar lavage. (D)</p> Signup and view all the answers

A patient not responding to antibiotics has an unidentified pathogen. Which of the following diagnostic procedures should be performed?

<p>Perform a bronchoscopy. (C)</p> Signup and view all the answers

A Gram stain reveals gram-positive cocci in clusters. What is the MOST likely organism?

<p><em>Staphylococcus aureus</em>. (C)</p> Signup and view all the answers

A patient presents with suspected pneumonia. Initial sputum Gram stain is inconclusive. Which test would provide the MOST rapid identification of a potential viral etiology?

<p>Molecular diagnostics (PCR). (B)</p> Signup and view all the answers

In a patient with severe pneumonia, procalcitonin levels might be measured. What is the PRIMARY utility of this measurement?

<p>Measuring disease severity and mortality predictors. (D)</p> Signup and view all the answers

A patient is suspected of having pneumonia. Which of the following diagnostic tests relies on identifying specific antibodies in the patient's serum rather than directly detecting the pathogen?

<p>Mycoplasma serology. (A)</p> Signup and view all the answers

Most cases of acute bronchitis are bacterial

<p>False (B)</p> Signup and view all the answers

What is pneumonia?

<p>Infection of the lung parenchyma</p> Signup and view all the answers

Which of the following is a mechanism for pneumonia?

<p>All of the above (F)</p> Signup and view all the answers

Which of the following is considered a typical CAP pathogen?

<p>All of the above (D)</p> Signup and view all the answers

Gram stain is helpful in diagnosing atypical organisms

<p>False (B)</p> Signup and view all the answers

Which of the following is true of pneumonia in nursing homes?

<p>Increased incidence of gram-negative organisms and staph aureus (D)</p> Signup and view all the answers

Which of the following is associated with Hospital-Acquired Pneumonia?

<p>All of the above (F)</p> Signup and view all the answers

Typical signs and symptoms of pneumonia include:

<p>All of the above (G)</p> Signup and view all the answers

Atypical pneumonia symptoms may include:

<p>All of the above (D)</p> Signup and view all the answers

COPD can be associated with what organism?

<p>H influenzae or M catarrhalis (C)</p> Signup and view all the answers

Alcoholism or Diabetes Mellitus can be associated with what organism?

<p>Klebsiella pneumoniae (A)</p> Signup and view all the answers

Asplenia is associated with what organism?

<p>S. pneumoniae, H. influenzae (A)</p> Signup and view all the answers

HIV infection is asscoiated with what organism?

<p>All of the above. (H)</p> Signup and view all the answers

Bronchiectasis or cystic fibrosis or ventilator related is asscoiated with what organism?

<p>Pseudomonas aeruginosa (B)</p> Signup and view all the answers

Travel to Mississippi, Ohio river valley is associated with what organism?

<p>Histoplasma capsulatum (A)</p> Signup and view all the answers

Travel to desert, southwest United State is associated with what organism?

<p>Coccidioides spp., Hantavirus (C)</p> Signup and view all the answers

Hotel or cruise ship stay in the previous 2 weeks can be a risk factor for?

<p>Legionella spp (D)</p> Signup and view all the answers

Which of the following describe S pneumoniae's character of sputum?

<p>Rust-colored sputum (B)</p> Signup and view all the answers

Klebsiella species is what type of sputum?

<p>Red currant jelly sputum. (C)</p> Signup and view all the answers

What is the first step in treatment for a patient as an Outpatient?

<p>All of the above if there are no comorbidities. (D)</p> Signup and view all the answers

What is the treatment for pnuemonia during influenza season?

<p>oseltamivir (Tamiflu), zanamivir (Relenza), peramivir (Rapivab), or baloxavir (Xofluza)</p> Signup and view all the answers

Describe first order actions for Inpatient, Non-ICU treatment?

<p>Beta-lactams (ampicillin/sulbactam, ceftriaxone, cefotaxime</p> Signup and view all the answers

What is the antibiotic length of treatment for pneumonia?

<p>5 Days (C)</p> Signup and view all the answers

If a patient is at a high risk of getting pneumonia what drug should you administer?

<p>Pneumococcal vaccine.</p> Signup and view all the answers

Mixed ______ bacteria are seen in most cases of lung abscess

<p>anaerobic</p> Signup and view all the answers

Within the United States, where can infection from Histoplasmosis occur?

<p>Ohio and Mississippi River valleys</p> Signup and view all the answers

How to treat a patient that has PCP?

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Flashcards

Pneumonia

Infection of the lung parenchyma.

Community-Acquired Pneumonia (CAP)

Pneumonia acquired outside of a hospital setting.

Hospital-Acquired Pneumonia (Nosocomial)

Pneumonia acquired in a hospital setting.

Acute Bronchitis (Etiology)

Most cases are caused by viruses.

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Acute Bronchitis (Symptoms)

Cough, fever, scattered rhonchi and wheezing.

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Acute Bronchitis (Treatment)

Rest, fluids, analgesics, bronchodilators.

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Pneumonia (Mechanisms)

Inhalation, aspiration, hematogenous spread, direct inoculation, contiguous spread, reactivation.

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"Typical" CAP Presentation

Fever, productive cough with purulent sputum, dyspnea, and pleuritic chest pain.

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Bordetella pertussis

Cough lasting >2 weeks with whooping sound or posttussive vomiting.

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Legionella spp

Hotel or cruise ship stay in previous 2 weeks, GI symptoms, headache, CNS symptoms.

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S pneumoniae

Associated with cough productive of rust-colored sputum.

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Pseudomonas, Haemophilus, and S pneumoniae

May produce green sputum.

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Klebsiella species pneumonia

Classically associated with cough productive of red currant jelly sputum.

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Anaerobic infections

Often produce foul-smelling or bad-tasting sputum.

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Atypical Pneumonia Symptoms

Mental confusion, prominent headaches, myalgias, ear pain, abdominal pain, diarrhea, rash, nonexudative pharyngitis, hemoptysis, splenomegaly, relative bradycardia.

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Interstitial Infiltrate Pathogens

Viruses, Pneumocystis, Mycoplasma, Chlamydia psittaci.

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Common CAP Bacteria

Bacterial species commonly associated with community-acquired pneumonia (CAP).

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CAP Pulmonary Findings

Lung findings include tachypnea and rales

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CAP Consolidation Signs

Increased tactile fremitus, bronchial breath sounds, egophony may be present if consolidation has occurred.

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Atypical Pneumonia Onset

Often presents gradually with less pronounced pulmonary symptoms.

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Atypical CAP Pathogens

Common atypical pathogens linked to community-acquired pneumonia.

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Other Atypical CAP pathogens

Variety of viruses or less likely bacteria are found in atypical CAP

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Extrapulmonary Manifestations

Symptoms beyond the lungs, like diarrhea or ear pain.

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Endemic Fungi Pneumonia

Fungi that can cause lung infections over a longer period.

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Coccidioides immitis

A fungus causing pneumonia, common in the southwestern United States.

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Nursing home pneumonia

Increased incidence of Gram-negative bacteria and Staphylococcus aureus.

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Hospital-Acquired Pneumonia Pathogens

Aerobic Gram-negative bacilli, Pseudomonas aeruginosa, Staphylococcus aureus, MRSA, and oral anaerobes.

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COPD-Associated Pneumonia

H. influenzae or M. catarrhalis.

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Pneumonia in Alcoholism/Diabetes

Klebsiella pneumoniae with "current jelly sputum".

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Asplenia-Associated Pneumonia

S. pneumoniae, H. influenzae.

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Pulse Oximetry

Initial assessment tool to measure oxygen saturation in the blood.

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Complete Blood Count (CBC)

Basic blood test to evaluate overall health and detect a wide range of disorders.

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Complete Metabolic Profile (CMP)

Comprehensive panel of blood tests providing a broad picture of your body's chemical balance and metabolism.

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Rapid Influenza Molecular Assay

Rapid diagnostic test to detect influenza virus.

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Sputum Gram Stain

Microscopic examination of sputum to identify bacteria.

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S. pneumoniae Gram Stain

Gram-positive cocci often appearing in pairs, a common cause of bacterial pneumonia.

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S. aureus Gram Stain

Gram-positive cocci often appearing in clumps, can cause a variety of infections including pneumonia.

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Pseudomonas Gram Stain

Gram-negative rod-shaped bacteria, a common cause of hospital-acquired infections like pneumonia.

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Hospital-Acquired (Nosocomial) Pneumonia

Pneumonia acquired in a hospital.

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Acute Bronchitis Cause

Usually viral.

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Pneumonia Treatment

Infection usually treated empirically.

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Haemophilus influenzae

A common bacterial cause of pneumonia, especially in COPD patients.

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Moraxella catarrhalis

A bacterial cause of pneumonia and other respiratory infections.

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Subacute/Indolent CAP

Often presents gradually and less severely than typical pneumonia.

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Mycoplasma pneumoniae

A common atypical pneumonia pathogen, often subacute.

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Chlamydophila pneumoniae

Causes atypical pneumonia; differentiate via serology.

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Legionella pneumophila

Causes Legionnaires' disease, a severe form of pneumonia.

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Influenza A and B

Viruses that can cause pneumonia

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Rhinovirus

Viruses that can cause pneumonia

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Common Nursing Home Pneumonia Pathogens

Gram-negative bacilli and Staph aureus are common pathogens.

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Hospital-Acquired Pneumonia (HAP)

Pneumonia acquired during a hospital stay.

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HAP Pathogens

Aerobic Gram-negative bacilli, Pseudomonas aeruginosa, Staphylococcus aureus (including MRSA), and oral anaerobes.

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COPD Pneumonia Pathogens

COPD predisposes to pneumonia from these organisms.

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Alcoholism/Diabetes Pneumonia Pathogen

Pneumonia in these patients increases risk of Klebsiella.

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Inhalation Anthrax

Illness caused by Bacillus anthracis associated with widened mediastinum on CXR.

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Rales

Localized sound of crackling quality heard during lung auscultation.

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Rhonchi

Coarse rattling respiratory sound, usually caused by secretions in the bronchial airways

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Dullness to Percussion

Increased lung tissue density.

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Increased Tactile Fremitus

Increased vibration intensity felt on the chest wall.

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Egophony

Change in spoken sounds through the lungs.

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Bronchophony

Increased loudness of spoken words through the lungs.

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Whispered Pectoriloquy

Clear transmission of whispered sounds through lungs.

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Procalcitonin & CRP

Test for patients at risk for worse outcomes in CAP, though controversial.

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Urinary Legionella Antigen

Test for Legionella infection, detecting antigens in urine.

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PCR Testing

Detects genetic material of pathogens, identifying specific organisms causing infection.

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Serology

Diagnostic test for Legionella, Mycoplasma and Chlamydophila infections.

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Bronchoscopy

Invasive procedure to collect lower respiratory tract specimens for diagnosis.

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Pleural Fluid Culture

Fluid sample from the lung, analyzed to diagnose infections or other lung conditions.

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Transthoracic Aspirate

Radiological procedure to obtain tissue sample by needle to check for malignancy or infection.

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Streptococcus pneumoniae

Gram-positive diplococci that is a common cause of community acquired pneumonia (CAP). Presents with fever, chills, cough with rusty brown sputum.

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Staphylococcus aureus

Gram-positive cocci in clumps, often seen in nursing home/hospital-acquired pneumonias, IV drug users, or post-influenza infections. Watch out for methicillin-resistant strains.

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Klebsiella pneumoniae

Gram-negative encapsulated rods, often seen in patients with ETOH abuse, diabetes mellitus, or hospital-acquired infections.

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Pseudomonas aeruginosa

Gram-negative rods seen in patients with cystic fibrosis, bronchiectasis, or hospital-acquired infections.

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Acute Bronchitis (Tx)

Rest, fluids, analgesics, bronchodilators.

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Pneumonia (Primary Mechanism)

Inhaling infectious particles.

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Pneumonia Aspiration

Aspiration of oropharyngeal/gastric contents.

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Typical CAP Symptoms

Classic symptoms include fever and productive cough with purulent sputum.

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S. pneumoniae (in CAP)

Most common bacterial cause of Community Acquired Pneumonia.

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Pneumonia Definition

Inflammation of the lung caused by various pathogens.

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Pneumonia Etiology

Caused by bacteria, viruses, and fungi.

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CAP Lung Sounds

Tachypnea, rales

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Consolidation Signs

Increased vibration, bronchial sounds, egophony if consolidation occurs.

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Atypical CAP Onset

Often gradual, less severe lung symptoms.

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Atypical Pathogens

Mycoplasma, Chlamydophila, Legionella.

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Common Viral Pathogens

Viruses: Influenza, Rhinovirus, Coronavirus

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Extrapulmonary Signs

Diarrhea, ear pain

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Pertussis Cough

Cough >2 weeks with a whooping sound or vomiting after coughing.

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Legionella Exposure

Stayed on a cruise or at a hotel and experiencing GI, headache or CNS symptoms.

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Rust-Colored Sputum

A cough that produces sputum with a rust tinge.

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Relative Bradycardia

Low heart rate relative to fever.

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Cavitary Lung Patterns

Bacterial, fungal, Nocardia, or TB infection exhibiting a cavity within lung tissue.

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Interstitial Pneumonia Pathogens

Viruses, Pneumocystis, Mycoplasma, Chlamydia psittaci.

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Mediastinal Widening

Illness related to widened mediastinum on CXR.

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Coccidioides immitis Pneumonia

Fungal infection caused by inhaling spores, common in the southwestern U.S.

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Nursing Home Pneumonia Risk

Pneumonia with increased Gram-negative bacteria and Staph aureus.

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Atypical Pneumonia Features

Confusion (Legionella), Diarrhea (Legionella), Rash (Mycoplasma).

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Current Jelly Sputum

Sputum described as thick and red, like currant jelly

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Aspiration Pneumonia Pathogens

Mixed aerobic and anaerobic organisms.

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Klebsiella Gram Stain

Gram-negative, encapsulated rod-shaped bacteria.

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Moraxella Gram Stain

Gram-negative diplococci (pairs of cocci).

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Diagnostic Testing

The process of examining sputum, fluid, or tissue to identify the cause of a patient's illness.

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Bronchoscopy Use

A procedure to visualize airways and air sacs.

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Lactic Acid Level

Acid measurement. Elevated levels indicate inadequate oxygen delivery.

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H. influenzae Gram Stain

Gram-negative coccobacilli.

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Pneumonia: Hematogenous Spread

Infection via the bloodstream, less common in those with intact immune systems.

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Typical Pneumonia Sputum

Often presents with purulent, not greenish, sputum.

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Increased Cellular Immunity

Protects against infection by fighting pathogens.

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Pneumonia: Aspiration Risk

Increases risk by allowing bacteria into the lungs.

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CAP: Streptococcus pneumoniae

The most common bacterial cause of community-acquired pneumonia.

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Non-responsive Pneumonia

Suggests a viral, fungal, or mycobacterial cause.

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Alcohol's Pneumonia Link

Leads to impaired neutrophil function, increasing pneumonia risk.

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Lobar Consolidation

More common in typical pneumonia presentations.

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Chlamydophila psittaci Risk

Linked to exposure to birds.

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Adenovirus Link

Also causes the common cold.

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Histoplasma capsulatum Source

Fungus found in Ohio River Valley, linked to caves with bat droppings.

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Coxiella burnetii Association

The cause of Q fever.

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Francisella tularensis Vector

Needs arthropod vectors (ticks, deer flies) for transmission.

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CMV Reactivation

A common cause of pneumonia after bone marrow transplants.

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Histoplasma Location

Associated with bat/bird droppings, causes granulomas.

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"Red Currant Jelly" Sputum

Classic sign of Klebsiella pneumoniae infection.

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Wheezing outside of pneumonia parameters

Indicates airway obstruction/diffuse process, not localized pneumonia.

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Cruise Ship Pneumonia

Suggests Legionella due to waterborne transmission on ships.

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Pneumonia and sputum

More typical of anaerobic, not S. pneumoniae, infections.

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Miliary Patterns

Suggestive of disseminated fungal/mycobacterial infections.

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Widened Mediastinum

Specific finding for inhalation anthrax.

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Atypical Pneumonia Signs

Suggests Mycoplasma pneumoniae.

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Bioterrorism Exposure in a pneumonia case

Should heighten suspicion for Bacillus anthracis.

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Urinary Antigen Testing

Highly specific for Legionella pneumophila serogroup 1.

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Bronchoalveolar Lavage

Allows visualization and sampling of lower respiratory tract.

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Needle Aspiration Diagnostic Aid

May provide critical information when other methods have failed.

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S. pneumoniae Serology

Of limited acute utility due to high prevalence from carriage/vaccination.

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Study Notes

Acute Bronchitis

  • Most cases are viral infections.
  • Cough, fever, scattered rhonchi, and wheezing are typical signs and symptoms.
  • Treatment includes rest, fluids, analgesics, and bronchodilators.

Pneumonia

  • Pneumonia is an infection of the lung parenchyma.
  • It is a frequent cause of death, especially in older adults with chronic diseases.
  • Types of Pneumonia include:
    • Community-acquired pneumonia (CAP)
    • Nursing home pneumonia
    • Hospital-acquired pneumonia (Nosocomial)
  • The infection is usually treated empirically
  • Mechanisms of pneumonia include:
    • Inhalation of infectious particles
    • Aspiration of oropharyngeal or gastric contents
    • Hematogenous deposition (uncommon)
    • Direct inoculation (uncommon)
    • Invasion from infection in contiguous structures (rare)
    • Re-activation (more common in immunocom promised patients)
  • Decreased resistance to pneumonia can occur with the following:
    • defects in pulmonary defenses
    • Decreased cellular and humoral immune response

“Typical” CAP Pathogens

  • Symptoms include: -Fever -A productive cough with purulent sputum -Dyspnea -Pleuritic chest pain
  • Tachypnea is present
  • Characteristic pulmonary findings: - Rales heard over the involved lobe or segment - Increased tactile fremitus - Bronchial breath sounds -Egophony
  • The most common pathogens:
    • Streptococcus pneumoniae
    • Haemophilus influenzae
    • Moraxella catarrhalis

Atypical CAP Pathogens

  • Often subacute and frequently indolent.
  • Sublte pulmonary findings such as nonlobar infiltrates on radiography
  • Various extrapulmonary manifestations such as diarrhea or otalgia.
  • Do not use brochials in atypical pneumonia
  • Pathogens include:
    • Mycoplasma pneumoniae
    • Chlamydophila (Chlamydia) pneumoniae
    • Legionella pneumophila

Nursing hone pneumonia

  • Increased incidence of gram negative and staph aureus

History and Physical Exam findings for pneumonia

  • Typical Symptoms: Hyperthermia or hypothermia, chills, tachypnea, tachycardia or bradycardia, productive cough (Note: elderly may present atypically)
  • Atypical pneumonia symptoms may also include: - Confusion (Legionella) - Diarrhea (Legionella) -Rash (Mycoplasma)
  • Kids are always tachypnic when infected

History and Associated Pulmonary Pathogen

  • COPD is associated with: Haemophilus influenzae or Moraxella catarrhalis
  • Alcoholism or Diabetes Mellitus with "current jelly sputum is associated Klebsiella pneumoniae
  • Ansplenia : is associated with S. pneumoniae, H. influenzae
  • HIV infection is associated with: Typical” bacterial pathogens, M. tuberculosis, Pneumocystis jiroveci, cytomegalovirus, Cryptococcus spp., Histoplasma spp., Coccidioides spp.
  • Bronchiectasis or cystic fibrosis or ventilator related Pseudomonas aeruginosa
  • Aspiration is associated with Mixed aerobic, anaerobic Exposure to birds: Chlamydia psittaci
  • Exposure to rabbits is associated with: Francisella tularensis
  • Travel to Mississippi, Ohio river valley is associated with: Histoplasma capsulatum
  • Travel to desert, southwest United is associated with: Coccidioides spp., Hantavirus
  • Contact with person known to have COVID-19. is associated with :COVID-19
  • Postinfluenza is associated with :S. Aureus or S. pneumoniae Cough >2 wk w/ whoop orPosttussive vomiting: Bordetella pertussis
  • Hotel or cruise ship stay in the previously 2 weeks is associated with : Legionella spp GI symptoms, headache CNS Bioterrorism:Bacillus anthracis

Character and Sputum

  • S pneumoniae is classically associated with a cough productive of rust-colored sputum.
  • Pseudomona, Haemophilus, and S Pneumonia: Green Sputum
  • Klebsiella apecies pneumonia is classucally associated with cough produce if red current jelly sputum
  • Anerobic infections often produce foul-smell or bad-tasting septum

Physical exam

  • Typical localized to a specific lungzone.
  • May include: Rales Rhonchi Bronchial breth sounds Dullness to percssuion Increased tactile fremitus Positive egophony, bronchophony, and whisper pectorlloquy. Diagnostic Testing for Pneumonia consider a pulse oximetry less than 90% COnsider a complete blood count consider a complete metabolic profile rapid influenza molecular assay if flue szn

Lung Image Patterns

Focal infiltratesare usually bacterial Large pleural effusion are usually batteral Cavity is due to: bacterial abcess, fungal , Nocardia, TB Millary us due to Interstital ussually Viral Pneumocysts pneumonia Mycoplasma, chamodula pstitaci Mediastinal widening Withoutinfiltrate: Inhalation Anthra

lung

Lrl pneumonia or RML pneumonia if in back

Prophylaxis for Pneumonia

consider the pneumonia severity index rather than just CURB65 Class 1 / class II: Outpatien therapy ( assumiin no pervious failure , hypoxia ,ability to tank in PA and comply to Tx)

CURB 65 Criteria

  • A score of 2 or more indicates hospital admission
  • Recent expansion include LDH, thobolytonemia, and serum albumin
  • Confusion Uremia (BUN 20mg/DL) Repirqotry Rate ( 30 min) Low Blood Pressure ( SbP < 90 or DBP < 60) Age ( 65 ya)

Outpatient Treatment Options

  • Know these too:
  • amoxicillin
  • A macrolide (azithromycin 500 mg once and then 250 mg daily or clarithromycin 500 mg twice daily)
    • good for S Preemo
  • Doxycycline 100 mg twice dailyis also an effective treatment option , good for atypical (pend in mcyin)
  • B- lactatam high dose : amoxicillin/ clavulavate 2 g twice 125 mg daily or 500mg 125 mg three the dayy or 875 mg three time daily cefpodimixe 200mg twic daily Respiruqotry florquinulones is muxofacacin + levoglaxacin

Inpatient Treatment Options

  • B- Lactas all atypical ampucuklln with sucullbactatame 1.5 gram every 6 hours, ceftriaxone 1 gram twice daily, cefotaxime 1.2 g daily or cell ratlinee 600 mg every 12 hour) plus a microlife + respitory flurquinolone Lactams as above + dxtrucuclune

Inpatient, Non-ICU Treatment

  • Beta-lactams (ampicillin/sulbactam 1.5-3 g every 6 hours, ceftriaxone 1-2 daily, cefotaxime 1-2 g every 8 hours, or celftaroline 60 mg every 12hours) plus a macro life
  • Respitory fluoroquinlome

ICU Treatment

  • beta lactatime+ respitio flu
  • beta lactivi + aztrenom
  • Beta-lactams (ampicillin/sulbactam 1.5-3 g every 6 hours, ceftriaxone 1-2 g daily, cefotaxime 1-2 g every 8 hours, or celftaroline 600 mg every 12hours) plus a macaroon lie + respitory flurquinolone
  • respiratory flurquinolone

Children Pneumonia treatment Considerations

  • Know these
  • High-dose amoxicillin is used as a first-line agent for children under 5 with uncomplicated community-acquired pneumonia
  • AVOID tetracyclines/doxycyline and flouroquinolones Macro lives as the empiric antibiotic choice for children aged 5-16 years (to cover mycoplasm, chamdo pholia leigonell)

During Iflu sneezing szn

  • Reasoanlele titatiiate oslatamiv (Tamiflu or relera

COVID-19 Treatment Options for Non-hospitalized patients

  • PAXLOviD and molupiravie reduce the risk in Covid related hospitaslziation or death
  • Monoclonal antibody bebtelovimab IV - FDA authorized – decreases risk for severe COVID-19 or hospitalization.
  • Only for people over age 12 with mild-moderate symptoms

Patient who dont reuspondd in 47 to 72 hrss: be recvaluagted

Special considerations for treatment

Penicillin/amoxicillin or other cell wall inhibitors do not cover atypicals

Special considerations for treatment

For greater gram negative coverage (ie with Klebsiella pneumoniae) RX a fluoroquinolone or a 3rd generation cephalosporin

Special treatment for pesudommaos or MrSA:

RX : Anitpseumonal B lacatam + anglysozde cirpoflaxin (CIPRO) + aninoglcysodie or : Add vancyoicing or linxolid • Anaerobes - RX Clindamycin or B-lactam/B lactamase inhiabiotyr

General treatment considerations

Antbioitics is Unclomaited patients, the Duartion shoul dbe 5 days If a patient is:

  • Pesudmonas 7 dys
  • MRSA :7 dayy

Atypical bacterial Infections

TB cxl and Sx - latent TB- treat wioth osanaizide 9 months supe,emnt with b

Prophylaxis for Pneumonia

  • Vaccinations pneumonia vacine COvid - flu vacine Consider the pneumonia severity index rather than just CURB65

Pulmaory abscess

Pulmonary Abscess

  • Patients with no gage reflex that gets aspirated Mixed anaerobic bacteria are seen in most cases

Lung Abscess

  • Alterations of consciousness, like alcholism in neroulgic disorders Atered consciousness can be caused by Peridonatal diseases Periodontal idssses are often present Mized anaerobia bacteria are seen in most cases Other conditions to lung broncial obsrution:

Other considerations for lobg abscess development

Nechtrozign baxteria Pneumoccus due to S aries K-o or g ramnegtaiuve Result of bonchual obsrtucio caused by fumors ore gin bldues seoptic pimaionray emboli

lung Abscess

Pulmonary tuberculosis, gung, or actionycises is often the resposblie In the innusupresse hots, nocadiuc andpther ipperutnistic The treatrmtnr conisrders anaerobic coverage: with beta Lactan or beat lactatam inbbitir and Clinimac

Brocasietes

Chasriztied by andquired dusease that leads to amonormal+ permnante dilation of bonichie and

Blatomycosis Considerations

Caused by he dimophic fungus balstonmycelium that lives in soil or decaying the woods or leaves endemiai in Midwest sauth central and southern states Cause symptoms in about 50% of people (pneumonia like symptoms) on cutaneous form & can cause severe illness such as meningtis inn iniummocomprised patient TX-is: antifungyal medication is ampho B and for mode rate to severe disease

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