Virus Classification and Families

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Questions and Answers

What characteristic differentiates rhabdoviruses from other virus families?

  • They have no impact on animal hosts.
  • They have minus-strand RNA genomes. (correct)
  • They contain double-stranded DNA genomes.
  • They are primarily transmitted through airborne particles.

Which severe outcome is commonly associated with H5N1 and H9N2 avian influenza viruses?

  • Increase in human-to-human transmission rates.
  • Mild respiratory symptoms without hospitalization.
  • Severe respiratory disease leading to death. (correct)
  • No documented cases of human infection.

What is a common mechanism for transmission of bird flu viruses to humans?

  • Infection through contaminated water supplies.
  • Direct contact with infected poultry or their feces. (correct)
  • Airborne spread through droplets in urban areas.
  • Indirect transmission via insect vectors.

Which characteristic is observed in some rhabdoviruses affecting animals?

<p>They often have a bullet-shaped virion structure. (B)</p> Signup and view all the answers

Which statement accurately describes the host range of rhabdoviruses?

<p>Many rhabdoviruses can infect a diverse range of organisms including plants and animals. (A)</p> Signup and view all the answers

What is a key characteristic of dependoviruses in relation to their replication?

<p>Dependoviruses require the help of other viruses or host cell proteins. (A)</p> Signup and view all the answers

What defines the terminal structure of some parvovirus genomes?

<p>They contain inverted terminal repeats (ITRs). (C)</p> Signup and view all the answers

Which of the following best describes the genome composition of picornaviruses?

<p>Single-stranded RNA consisting of 7–8 kb. (D)</p> Signup and view all the answers

Which families are classified under the term 'Reoviridae'?

<p>Viruses with dsRNA genomes linked to various diseases in different species. (D)</p> Signup and view all the answers

What is the significance of the S phase of the cell cycle for parvovirus replication?

<p>Important host proteins necessary for replication are only available during the S phase. (C)</p> Signup and view all the answers

Flashcards

Parvovirus genome structure

Parvoviruses have small, single-stranded DNA genomes with inverted terminal repeats (ITRs) at the ends.

Dependoviruses replication

Some dependoviruses can replicate without a helper virus, but others rely on adenoviruses for replication.

Parvovirus replication timing

Parvovirus replication is limited to the S phase of the cell cycle because critical proteins are only available then.

Reovirus origin

Reoviruses were initially characterized as viruses found in respiratory and intestinal tracts, without apparent disease.

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Picornavirus genome size

Picornaviruses have small, single-stranded RNA genomes (7-8 kb).

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Avian Influenza Viruses

Influenza viruses that infect birds, some of which can infect humans and are highly pathogenic (harmful), causing severe respiratory disease and sometimes death.

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H5N1 Virus

A highly pathogenic avian influenza virus that caused a serious outbreak in poultry in Hong Kong in 1997 and spread to other Asian countries, Europe, and Africa later.

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Rhabdoviruses

Viruses with minus-strand RNA genomes, often rod-shaped in plants or bullet-shaped in animals. They infect mammals, fish, plants, and insects.

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Rabies Virus

A rhabdovirus with a wide host range, highly pathogenic in mammals. Symptoms are typically severe.

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Human-to-human Transmission

The spread of a virus from one human to another.

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Study Notes

Virus Classification

  • Virus families are classified based on their Baltimore classification system
  • DNA viruses are grouped into several classes (e.g., Herpesviruses, Adenoviruses, Poxviruses, Parvoviruses)
  • RNA viruses are also categorized into classes (e.g., Picornaviruses, Orthomyxoviruses, Retroviruses, etc.)

Herpesviruses

  • Herpesviruses are broadly classified into three subfamilies: alpha, beta, and gamma
  • HSV-1 and HSV-2 cause oral and genital herpes, respectively
  • Varicella-zoster virus (VZV) causes chickenpox and shingles
  • Human cytomegalovirus (HCMV) is commonly associated with infectious mononucleosis
  • Epstein-Barr virus (EBV) is a cofactor in some human cancers

Adenoviruses

  • Adenoviruses are linear double-stranded DNA viruses
  • They have a large size range between 30-38 kbp in size

Poliovirus

  • One of the first viruses to be propagated in cell culture
  • It was also one of the first to be plaque purified

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