Virus-Based Vaccines Quiz

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Questions and Answers

What is the benefit of memory immune responses for an immunized individual?

  • They are similar in speed and strength to an unimmunized individual
  • They do not provide any benefit
  • They are faster and stronger than for an unimmunized individual (correct)
  • They are slower and weaker than for an unimmunized individual

How does herd immunity contribute to protecting newborns and infants?

  • It has no impact on protecting newborns and infants
  • It increases the risk of diseases in newborns and infants
  • It reduces the number of susceptible hosts, indirectly protecting them (correct)
  • It directly vaccinates newborns and infants

Which of the following is NOT a goal achieved by national and international immunization programs mentioned in the text?

  • Reduction in cancer risk caused by HPV infections
  • Elimination of tuberculosis worldwide (correct)
  • Control of the spread of rubella, varicella zoster virus, and rotavirus
  • Protection from diphtheria, tetanus, and rabies

What additional measures, mentioned in the text, can be taken to prevent disease apart from immunization programs?

<p>Water purification to eliminate the source of infection (A)</p> Signup and view all the answers

Which bacterial vaccine is recommended for children and adults to prevent tetanus?

<p>Clostridium tetani (tetanus) Toxoid (A)</p> Signup and view all the answers

Who should receive the Bordetella pertussis vaccine according to the information provided?

<p>Children and adults (B)</p> Signup and view all the answers

Which bacterial vaccine is specifically recommended for travelers to cholera epidemic areas?

<p>Vibrio cholerae (cholera) (D)</p> Signup and view all the answers

What is the component of the Haemophilus influenzae B (Hib) vaccine?

<p>Capsule polysaccharide-protein conjugate (B)</p> Signup and view all the answers

Which bacterial vaccine is specifically for sheep handlers and laboratory personnel working with Coxiella burnetii?

<p>Coxiella burnetii (Q fever) (C)</p> Signup and view all the answers

What type of components elicit a protective immune response in a subunit vaccine?

<p>Surface structures of bacteria and viral attachment proteins (B)</p> Signup and view all the answers

What type of bacterial vaccines protect against the pathogenic action of toxins mainly?

<p>Toxoid bacterial vaccines (A)</p> Signup and view all the answers

What type of bacterial vaccines are currently available according to the information provided?

<p>Surface components of bacteria (A)</p> Signup and view all the answers

What is the primary method of preparing a rabies vaccine?

<p>Killed cell preparation using chemical inactivation (C)</p> Signup and view all the answers

What are the main components of the Bordetella pertussis vaccine?

<p>Acellular pertussis components (B)</p> Signup and view all the answers

What is the main difference between passive and active immunization?

<p>The route of administration (C)</p> Signup and view all the answers

Which method is NOT used to produce inactivated vaccines?

<p>Live virus purification (A)</p> Signup and view all the answers

What type of immune response does inactivated vaccine usually generate?

<p>TH2 response (A)</p> Signup and view all the answers

Which of the following is a common adjuvant used in vaccines?

<p>Aluminum hydroxide (C)</p> Signup and view all the answers

Which route of administration is associated with live vaccines?

<p>Oral or respiratory (B)</p> Signup and view all the answers

Why are inactivated vaccines generally considered safe?

<p>They cannot cause the disease (A)</p> Signup and view all the answers

'MF59' is a component used in which vaccine?

<p>Fluad influenza vaccine (D)</p> Signup and view all the answers

'Virus-like particles (VLPs)' belong to which category of adjuvants?

<p>'Virus-like particles (VLPs)' are not an adjuvant (C)</p> Signup and view all the answers

Which statement about live vaccines is true?

<p>They can cause reversion to virulence. (C)</p> Signup and view all the answers

What is the main advantage of live vaccines over inactivated vaccines according to Table 11.2?

<p>Long-term duration of immunity (D)</p> Signup and view all the answers

Which component is NOT typically used as an experimental adjuvant according to the text?

<p>Live virus purification (D)</p> Signup and view all the answers

What characteristic makes aluminum hydroxide a common adjuvant?

<p>It enhances uptake by antigen-presenting cells. (C)</p> Signup and view all the answers

How are subunit vaccines like the HBV and HPV vaccines different from individual proteins?

<p>They are more immunogenic (B)</p> Signup and view all the answers

Which process is involved in enhancing the immunogenicity of polysaccharides?

<p>Chemical linkage to a protein carrier (D)</p> Signup and view all the answers

What is the reason behind preparing live vaccines with microbes limited in their ability to cause disease?

<p>To mimic the natural immune response (D)</p> Signup and view all the answers

What is the primary issue with live vaccines in relation to immunosuppressed individuals?

<p>They may still pose a danger as the virus is weakened, not eliminated (B)</p> Signup and view all the answers

How are most inactivated annual influenza vaccines prepared?

<p>From a mixture of hemagglutinin and neuraminidase proteins (D)</p> Signup and view all the answers

Which protein carrier is mentioned in the text for enhancing the immunogenicity of polysaccharides?

<p>Diphtheria toxoid (A)</p> Signup and view all the answers

What type of immune response do live vaccines help develop?

<p><strong>Humoral</strong> and cellular immune responses (C)</p> Signup and view all the answers

Why are subunit proteins used in some vaccines like HPV and HBV instead of individual proteins?

<p>Because subunit proteins form VLPs that are more immunogenic (D)</p> Signup and view all the answers

What is the function of alum in vaccine preparation mentioned in the text?

<p>To enhance immunogenicity of polysaccharides (C)</p> Signup and view all the answers

Why is it important to make polysaccharides into T-dependent antigens?

<p>To increase their T-cell help (A)</p> Signup and view all the answers

Which type of virus requires T-cell immune responses for resolution and is specifically mentioned in the text?

<p>Enveloped virus (D)</p> Signup and view all the answers

What is the primary method mentioned in the text to identify appropriate immunogens for vaccine development?

<p>Analyzing antibody from survivors of infections (B)</p> Signup and view all the answers

What is a key prerequisite for developing vaccines against infectious agents?

<p>Isolating the gene of the protective immunogen (B)</p> Signup and view all the answers

How can an effective vaccine program, as described in the text, be beneficial in terms of health care costs?

<p>It can save millions of dollars by preventing infections (B)</p> Signup and view all the answers

What was the primary method used to eliminate natural smallpox as of 1977?

<p>Combination of vaccination and quarantine (D)</p> Signup and view all the answers

Why do vaccine-preventable diseases still occur in some regions?

<p>Misinformation and complacency (B)</p> Signup and view all the answers

Which type of immunity is obtained when newborns receive maternal immunoglobulin through the placenta or breast milk?

<p>Passive immunity (D)</p> Signup and view all the answers

What is the term for injecting purified antibody, antibody-containing serum, or immune cells to provide temporary protection?

<p>Passive immunization (C)</p> Signup and view all the answers

Which type of immunization occurs when an immune response is stimulated through exposure to an infectious agent or vaccine?

<p>Active immunization (A)</p> Signup and view all the answers

What is the primary reason for using passive immunization after a known exposure?

<p>To prevent disease (B)</p> Signup and view all the answers

Which type of immunity involves therapeutic antibodies blocking autoimmune responses?

<p>Passive immunity (C)</p> Signup and view all the answers

'Monoclonal antibody preparations are being developed for what purpose?'

<p>'To block cytokine and cellular responses' (D)</p> Signup and view all the answers

'Which type of vaccines elicit an immune response on infection?'

<p>'Live vaccines such as vaccinia' (C)</p> Signup and view all the answers

'What is the primary advantage of human immunoglobulin over animal immunoglobulin?'

<p>'Reduced risk of hypersensitivity reactions' (A)</p> Signup and view all the answers

'Why are newer approaches like DNA or RNA vaccines used for immunization?'

<p>'To avoid possible side effects from live vaccines' (A)</p> Signup and view all the answers

'Which diseases can be prevented using immune serum globulin preparations?'

<p>'Botulism and Diphtheria' (D)</p> Signup and view all the answers

What is the main purpose of a hybrid virus vaccine upon infection?

<p>Promote expression of inserted gene to initiate an immune response (A)</p> Signup and view all the answers

Which type of vaccine showed modest but promising results when followed by two booster immunizations with recombinant HIV gp120 protein?

<p>Canarypox human immunodeficiency virus (HIV) vaccine (D)</p> Signup and view all the answers

What is the main difficulty faced in the development of genetically engineered subunit vaccines?

<p>Identifying the appropriate subunit or peptide immunogen (D)</p> Signup and view all the answers

Which proteins have been generated in bacteria or eukaryotic cells for use as subunit vaccines?

<p>G antigen of rabies and glycoprotein D of herpes simplex virus (B)</p> Signup and view all the answers

How can the immunogenicity of peptide subunit vaccines be enhanced?

<p>By attaching them to a carrier protein (D)</p> Signup and view all the answers

What can enhance the immunogenicity and direct the response of vaccines to a TH1-type or TH2-type response apart from alum?

<p>Flagellin (B)</p> Signup and view all the answers

How are DNA vaccines delivered into the recipient's body?

<p>Delivery into muscle or skin (B)</p> Signup and view all the answers

What is a characteristic feature of RNA vaccines?

<p>They require booster shots with antigenic protein (B)</p> Signup and view all the answers

Which type of vaccine offers great potential for tumor immunotherapy?

<p>DNA vaccine (A)</p> Signup and view all the answers

What does reverse vaccinology involve?

<p>Developing vaccines based on the genetic makeup of pathogens. (A)</p> Signup and view all the answers

Which method is used to prepare autologous activated DCs loaded with tumor antigens for immunotherapy?

<p>Using the patient's own cells. (A)</p> Signup and view all the answers

What is the benefit of including genes for immunoenhancing cytokines in RNA vaccines?

<p>Boosting the potency of the vaccine. (B)</p> Signup and view all the answers

Which vaccine elicits potent cellular immune responses and immune memory necessary for protection from measles, mumps, and rubella viruses?

<p>MMR vaccine (D)</p> Signup and view all the answers

Why must the MMR vaccine be administered after 1 year of age?

<p>To avoid maternal antibodies interference (D)</p> Signup and view all the answers

Which virus is used as a vector for inserting genes from infectious agents to create hybrid virus vaccines?

<p>Vaccinia virus (D)</p> Signup and view all the answers

Which vaccine induced more serious symptoms (atypical measles) when challenged with wild-type measles virus?

<p>Live measles vaccine (C)</p> Signup and view all the answers

Which age group should receive the high dose or adjuvanted influenza vaccine according to the text?

<p>Adults over 65 years (D)</p> Signup and view all the answers

In which areas should children receive the live (oral) polio vaccine according to the text?

<p>Epidemic areas (A)</p> Signup and view all the answers

Which strain of measles virus is currently used in the United States?

<p>Moraten (A)</p> Signup and view all the answers

What is the purpose of developing new live vaccines using genetic engineering mutations as mentioned in the text?

<p>To allow multiple agents in a single vaccine (A)</p> Signup and view all the answers

At what temperature are live attenuated influenza vaccines administered?

<p>25° C (A)</p> Signup and view all the answers

Which age group should receive the varicella zoster vaccine with an adjuvanted gpE?

<p>Adults over 60 years old (B)</p> Signup and view all the answers

Which group should receive the hepatitis B subunit (VLP) vaccine according to the text?

<p>Newborns, health care workers, high-risk groups only (B)</p> Signup and view all the answers

Which type of rotavirus vaccine should be administered to infants according to the text?

<p>Attenuated human-bovine hybrids (C)</p> Signup and view all the answers

What is the main reason why the BCG vaccine is not used in the United States?

<p>It causes a false-positive skin reaction to the PPD test. (C)</p> Signup and view all the answers

What method is used to attenuate wild-type viruses in live virus vaccines?

<p>Growth in animals at nonphysiological temperatures. (B)</p> Signup and view all the answers

Which type of vaccine replicates in the gastrointestinal tract but does not reach or infect neurons?

<p>Polio vaccine (D)</p> Signup and view all the answers

What is the basis for one of the current vaccines administered to protect infants against human rotavirus?

<p>Mixture of genetic reassortant human and bovine rotaviruses. (A)</p> Signup and view all the answers

What is the main advantage of the live oral polio vaccine (OPV) developed by Albert Sabin?

<p>It can spread to contacts of the immunized individual. (B)</p> Signup and view all the answers

Why is the IPV now used for routine immunizations instead of the OPV in most parts of the world?

<p>It provides better protection against polio disease. (D)</p> Signup and view all the answers

What is a characteristic of the HBV and HPV vaccines?

<p>They form VLPs that are better immunogens than individual proteins. (B)</p> Signup and view all the answers

How were at least 57 mutations accumulated in the polio type 1 vaccine strain?

<p>Multiple passages through monkey kidney tissue culture cells. (A)</p> Signup and view all the answers

What is a disadvantage of using the BCG vaccine for tuberculosis?

<p>It does not always offer protective immunity. (B)</p> Signup and view all the answers

Why are live bacterial vaccines especially important for some bacteria?

<p>Because they require a combination of antibody and cell-mediated immune responses. (A)</p> Signup and view all the answers

In which country is the BCG vaccine not used due to a false-positive skin reaction to the PPD test?

<p>United States (B)</p> Signup and view all the answers

Which type of virus vaccines consist of less virulent mutants or genetically engineered viruses?

<p>Live virus vaccines (C)</p> Signup and view all the answers

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