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Questions and Answers

definition of pathology

  • The treatment of diseases through medication
  • The study of disease and disease processes by scientific methods (correct)
  • The prevention of diseases through vaccination
  • The classification of different diseases based on symptoms
  • Which of the following is an example of a primary genetic disease?

  • Malignant melanoma
  • Haemophilia (correct)
  • Iodine deficiency
  • Compound fracture
  • Which of the following is NOT an aspect of the disease process in pathology?

  • Aetiology
  • Pathogenesis
  • Morphology
  • Epidemiology (correct)
  • What is hypoxia?

    <p>Decrease in oxygen supply to tissues (A)</p> Signup and view all the answers

    Which of the following contributes to impaired respiratory defense mechanisms, increasing pneumonia risk?

    <p>Cough reflex suppression due to drugs (C)</p> Signup and view all the answers

    What is the primary cause of lobar pneumonia?

    <p>Streptococcus pneumoniae (B)</p> Signup and view all the answers

    What is the key feature of bronchopneumonia?

    <p>Starts in the bronchi and spreads to alveoli (B)</p> Signup and view all the answers

    Which type of pneumonia is most commonly acquired in hospitals?

    <p>nosocomial (C)</p> Signup and view all the answers

    What is the primary lesion in primary tuberculosis called?

    <p>ghon focus (B)</p> Signup and view all the answers

    What is the primary mode of transmission of Mycobacterium tuberculosis?

    <p>Inhalation of infected droplets (B)</p> Signup and view all the answers

    What controls most endocrine glands?

    <p>Hypothalamic-pituitary axis (B)</p> Signup and view all the answers

    What is the primary cause of pituitary hyperfunction?

    <p>Pituitary adenoma (A)</p> Signup and view all the answers

    Which of the following is a characteristic symptom of acromegaly?

    <p>Enlarged hands and feet (B)</p> Signup and view all the answers

    Which hormone is overproduced in Cushing syndrome due to an ACTH-secreting adenoma?

    <p>cortisol (B)</p> Signup and view all the answers

    What is the most common cause of primary hyperparathyroidism?

    <p>Parathyroid adenoma (A)</p> Signup and view all the answers

    What is a major cause of secondary adrenal insufficiency?

    <p>Pituitary disease (A)</p> Signup and view all the answers

    What type of diabetes is characterized by insulin resistance and adult onset?

    <p>Type 2 diabetes mellitus (B)</p> Signup and view all the answers

    Which condition is associated with hyperthyroidism and exophthalmos?

    <p>Graves' disease (C)</p> Signup and view all the answers

    What is the primary cause of Conn syndrome?

    <p>Adrenal adenoma (A)</p> Signup and view all the answers

    What is the most common acute complication of type 1 diabetes?

    <p>Diabetic ketoacidosis (B)</p> Signup and view all the answers

    What percentage of total body weight is water in males?

    <p>60 (C)</p> Signup and view all the answers

    Which hormone is primarily responsible for water retention by increasing kidney reabsorption of water?

    <p>vasopressin (ADH) (B)</p> Signup and view all the answers

    Which of the following is NOT a cause of excessive fluid loss leading to dehydration?

    <p>Hypertension (D)</p> Signup and view all the answers

    What is the primary cause of hypernatraemia?

    <p>Excessive sodium retention (C)</p> Signup and view all the answers

    Which of the following is a symptom of hyponatraemia?

    <p>Lethargy and confusion (B)</p> Signup and view all the answers

    A patient presents with peaked T waves on an ECG. Which electrolyte imbalance is most likely responsible?

    <p>Hyperkalaemia (B)</p> Signup and view all the answers

    What is the most common cause of primary hyperaldosteronism (Conn syndrome)?

    <p>Bilateral adrenal hyperplasia (B)</p> Signup and view all the answers

    Which condition is characterized by carpal spasm induced by inflation of a blood pressure cuff (Trousseau’s sign)?

    <p>hypocalcemia (B)</p> Signup and view all the answers

    Which of the following is a common cause of metabolic acidosis?

    <p>Diabetic ketoacidosis (C)</p> Signup and view all the answers

    Which of the following conditions is caused by alveolar hyperventilation?

    <p>Respiratory alkalosis (B)</p> Signup and view all the answers

    What is the primary cause of Ischaemic Heart Disease (IHD)?

    <p>Atheroma (plaque buildup) in coronary arteries (B)</p> Signup and view all the answers

    Which of the following is a major contributing factor to acute coronary syndrome (ACS)?

    <p>Plaque rupture and thrombosis (C)</p> Signup and view all the answers

    Which coronary artery supplies the anterior wall of the left ventricle?

    <p>Left anterior descending (LAD) (B)</p> Signup and view all the answers

    What is the most common early complication of myocardial infarction (MI)?

    <p>Arrhythmias (C)</p> Signup and view all the answers

    Which of the following is a modifiable risk factor for myocardial infarction?

    <p>smoking (C)</p> Signup and view all the answers

    Which condition is characterized by chest pain that occurs predictably with exertion and resolves with rest?

    <p>Stable angina (B)</p> Signup and view all the answers

    What is the primary hormone involved in regulating blood pressure via the renin-angiotensin-aldosterone system (RAAS)?

    <p>angiotensin II (C)</p> Signup and view all the answers

    Which of the following is a common cause of secondary hypertension?

    <p>Renal artery stenosis (B)</p> Signup and view all the answers

    What is the main consequence of untreated hypertension on the heart?

    <p>Left ventricular hypertrophy (B)</p> Signup and view all the answers

    What condition occurs when blood accumulates in the pericardial sac, compressing the heart and impairing its function?

    <p>Cardiac tamponade (B)</p> Signup and view all the answers

    Which type of cells have excellent regenerative ability and a high turnover rate?

    <p>labile (C)</p> Signup and view all the answers

    What phase of the cell cycle involves DNA replication?

    <p>S (B)</p> Signup and view all the answers

    Which of the following is an example of physiological hypertrophy?

    <p>Muscle growth due to exercise (B)</p> Signup and view all the answers

    What is the primary cause of agenesis?

    <p>Failure of an organ to develop (B)</p> Signup and view all the answers

    What hormone primarily influences fetal growth by promoting cellular growth and metabolism?

    <p>Insulin (A)</p> Signup and view all the answers

    Which of the following is a common symptom of diabetes mellitus?

    <p>Polyuria (frequent urination) (B)</p> Signup and view all the answers

    What is the primary cause of glycogen storage diseases?

    <p>Enzyme deficiencies affecting glycogen metabolism (B)</p> Signup and view all the answers

    Which vitamin is fat-soluble and can be toxic in excess?

    <p>Vitamin D (C)</p> Signup and view all the answers

    Cystic fibrosis is caused by a mutation in which protein?

    <p>CFTR (cystic fibrosis transmembrane conductance regulator) (A)</p> Signup and view all the answers

    What condition results from a lack of protein but adequate energy intake in children?

    <p>Kwashiorkor (B)</p> Signup and view all the answers

    What is a common occupational exposure that increases the risk of mesothelioma?

    <p>Asbestos (B)</p> Signup and view all the answers

    What is the effect of leptin on energy balance?

    <p>Inhibits food intake and increases energy expenditure (B)</p> Signup and view all the answers

    Which radiation type causes ionization and potential DNA damage?

    <p>xrays (C)</p> Signup and view all the answers

    What is a major health consequence of tobacco smoking?

    <p>Chronic bronchitis (B)</p> Signup and view all the answers

    Which enzyme deficiency causes albinism?

    <p>Tyrosinase (A)</p> Signup and view all the answers

    Which hormone primarily regulates erythropoiesis?

    <p>Erythropoietin (B)</p> Signup and view all the answers

    What is the primary cause of iron deficiency anemia?

    <p>Inadequate iron intake and blood loss (B)</p> Signup and view all the answers

    Which of the following is a feature of megaloblastic anemia?

    <p>Deficiency of Vitamin B12 or folate (B)</p> Signup and view all the answers

    What is a common symptom of polycythemia?

    <p>Visual disturbances and headaches (B)</p> Signup and view all the answers

    Which of the following is a common feature of haemolytic anemia?

    <p>Jaundice and splenomegaly (B)</p> Signup and view all the answers

    Which condition is characterized by low bone mineral density with normal mineralization?

    <p>Osteoporosis (A)</p> Signup and view all the answers

    Which of the following is a characteristic feature of osteoarthritis?

    <p>Crepitus during joint movement (C)</p> Signup and view all the answers

    What is the primary cause of rickets in children?

    <p>Vitamin D deficiency (B)</p> Signup and view all the answers

    Which of the following is an example of a primary bone tumor?

    <p>Osteosarcoma (A)</p> Signup and view all the answers

    What is a typical complication of osteoporosis?

    <p>Pathological fractures (A)</p> Signup and view all the answers

    Which of the following is a systemic inflammatory disorder involving joints, often associated with rheumatoid factor?

    <p>Rheumatoid arthritis (B)</p> Signup and view all the answers

    Which of the following factors increases the risk of osteoporosis in postmenopausal women?

    <p>Decreased physical activity (B)</p> Signup and view all the answers

    What is the most common joint affected in acute gout?

    <p>First metatarsophalangeal joint (big toe) (D)</p> Signup and view all the answers

    Which of the following is the most common cause of peptic ulcer disease?

    <p>Helicobacter pylori infection (D)</p> Signup and view all the answers

    Squamous cell carcinoma of the esophagus is most commonly associated with which risk factor?

    <p>Tobacco and alcohol use (C)</p> Signup and view all the answers

    What condition is characterized by the presence of non-caseating granulomas and transmural inflammation?

    <p>Crohn’s disease (B)</p> Signup and view all the answers

    Which of the following types of hepatitis has the highest likelihood of progressing to chronic disease?

    <p>c (C)</p> Signup and view all the answers

    What is the most common site of adenocarcinoma in the stomach?

    <p>antrum (D)</p> Signup and view all the answers

    What is the hallmark histological feature of ulcerative colitis?

    <p>Crypt abscesses (C)</p> Signup and view all the answers

    What is the primary diagnostic test for celiac disease?

    <p>Antitransglutaminase antibodies test (B)</p> Signup and view all the answers

    Which of the following complications is most commonly associated with diverticulitis?

    <p>Perforation (A)</p> Signup and view all the answers

    Which of the following types of jaundice is caused by obstruction of bile flow?

    <p>Post-hepatic (C)</p> Signup and view all the answers

    Which of the following is a significant risk factor for pancreatic cancer?

    <p>smoking (C)</p> Signup and view all the answers

    The presence of HBsAg in a patient indicates what stage of hepatitis B infection?

    <p>Chronic or active infection (B)</p> Signup and view all the answers

    Which of the following is a feature of acute pancreatitis?

    <p>Autodigestion of pancreatic tissue (C)</p> Signup and view all the answers

    Which condition is characterized by skip lesions in the gastrointestinal tract?

    <p>Crohn’s disease (B)</p> Signup and view all the answers

    What is the key characteristic that differentiates malignant tumors from benign tumors?

    <p>Ability to metastasize (B)</p> Signup and view all the answers

    Which term refers to a benign tumor of glandular tissue?

    <p>Adenoma (C)</p> Signup and view all the answers

    Which of the following genetic mutations is associated with uncontrolled cell replication in cancer?

    <p>Oncogene activation (B)</p> Signup and view all the answers

    What is the most common pathway for the spread of carcinomas?

    <p>Lymphatic spread (B)</p> Signup and view all the answers

    Which stage of cancer development refers to abnormal cell growth that has not yet invaded surrounding tissues?

    <p>Dysplasia (C)</p> Signup and view all the answers

    Which of the following is a hallmark feature of malignant tumors?

    <p>Anaplasia (C)</p> Signup and view all the answers

    What is the primary route of metastasis for sarcomas?

    <p>Bloodstream (B)</p> Signup and view all the answers

    Which of the following tumor types originates from connective tissue?

    <p>Sarcoma (B)</p> Signup and view all the answers

    What is the role of tumor suppressor genes in cancer prevention?

    <p>Regulate cell division and promote apoptosis (C)</p> Signup and view all the answers

    Which term describes cancer that has spread from its primary site to distant organs?

    <p>Metastasis (C)</p> Signup and view all the answers

    What is the primary component of the atheromatous core in atherosclerosis?

    <p>Lipids and necrotic debris (B)</p> Signup and view all the answers

    Which of the following is a modifiable risk factor for atherosclerosis?

    <p>Smoking (C)</p> Signup and view all the answers

    What is the primary mechanism behind the formation of atherosclerotic plaques?

    <p>Response-to-injury hypothesis involving endothelial damage (B)</p> Signup and view all the answers

    Which of the following arteries is commonly affected by atherosclerosis?

    <p>Elastic arteries like the aorta (B)</p> Signup and view all the answers

    Which of the following is the primary characteristic cell involved in acute inflammation?

    <p>Neutrophils (B)</p> Signup and view all the answers

    What is the primary function of Toll-like receptors (TLRs) in inflammation?

    <p>Recognize pathogen-associated molecular patterns (PAMPs) (B)</p> Signup and view all the answers

    Which of the following is a feature of chronic inflammation?

    <p>Presence of mononuclear cells such as macrophages and lymphocytes (B)</p> Signup and view all the answers

    Which mediator is primarily responsible for vasodilation during the inflammatory response?

    <p>Histamine (A)</p> Signup and view all the answers

    What is the hallmark histological feature of granulomatous inflammation?

    <p>Giant cells surrounded by lymphocytes (B)</p> Signup and view all the answers

    Which of the following is an example of reversible cell injury?

    <p>Cellular swelling (C)</p> Signup and view all the answers

    What is the primary difference between necrosis and apoptosis?

    <p>Necrosis is unplanned and often involves inflammation, while apoptosis is a controlled process (B)</p> Signup and view all the answers

    Which of the following cellular adaptations involves an increase in cell number?

    <p>Hyperplasia (D)</p> Signup and view all the answers

    What is a common consequence of reperfusion injury?

    <p>Oxidative stress and inflammation (B)</p> Signup and view all the answers

    Which of the following accumulations is commonly seen in the liver due to alcohol abuse?

    <p>Steatosis (fatty change) (C)</p> Signup and view all the answers

    Which of the following bacteria is the most common cause of urinary tract infections (UTIs)?

    <p>Escherichia coli (B)</p> Signup and view all the answers

    What is the most common risk factor for urinary bladder malignancy?

    <p>Smoking (B)</p> Signup and view all the answers

    Benign prostatic hyperplasia (BPH) most commonly affects which part of the prostate?

    <p>Transitional and central zones (B)</p> Signup and view all the answers

    Which of the following is the most common presentation of urinary bladder malignancy?

    <p>Painless hematuria (C)</p> Signup and view all the answers

    Testicular torsion primarily affects which age group?

    <p>adolescents (B)</p> Signup and view all the answers

    Which of the following is considered a premalignant skin lesion?

    <p>Actinic keratosis (B)</p> Signup and view all the answers

    What is the most common type of skin cancer?

    <p>Basal cell carcinoma (B)</p> Signup and view all the answers

    Which of the following is a risk factor for squamous cell carcinoma?

    <p>UV radiation exposure (B)</p> Signup and view all the answers

    What is the hallmark feature of melanoma using the ABCDE rule?

    <p>Asymmetry, Border irregularity, Color variation, Diameter &gt;6mm, Evolution (A)</p> Signup and view all the answers

    What is the primary treatment for malignant melanoma?

    <p>Wide excision surgery (C)</p> Signup and view all the answers

    Which virus is most commonly associated with cervical cancer?

    <p>Human papillomavirus (HPV) (B)</p> Signup and view all the answers

    Which of the following is a common risk factor for endometrial carcinoma?

    <p>Prolonged estrogen exposure (B)</p> Signup and view all the answers

    What is the most common benign tumor of the uterus?

    <p>Leiomyoma (fibroid) (C)</p> Signup and view all the answers

    Which ovarian tumor type is most frequently encountered?

    <p>Epithelial tumors (C)</p> Signup and view all the answers

    What is the hallmark symptom of endometrial carcinoma?

    <p>Abnormal vaginal bleeding (B)</p> Signup and view all the answers

    Which breast cancer type is the most common?

    <p>Invasive ductal carcinoma (B)</p> Signup and view all the answers

    What screening test is commonly used for cervical cancer detection?

    <p>Pap smear (C)</p> Signup and view all the answers

    Which of the following breast conditions is typically benign?

    <p>Fibroadenoma (A)</p> Signup and view all the answers

    What is a common characteristic of polycystic ovarian syndrome (PCOS)?

    <p>Multiple ovarian cysts (C)</p> Signup and view all the answers

    What is the primary method of treatment for early-stage cervical intraepithelial neoplasia (CIN)?

    <p>Cryotherapy or LEEP (B)</p> Signup and view all the answers

    Which of the following is the most common cause of nephrotic syndrome?

    <p>Massive proteinuria (&gt;3.5g/day) (B)</p> Signup and view all the answers

    What is the most common type of renal stone?

    <p>Calcium oxalate stones (D)</p> Signup and view all the answers

    Which of the following is a characteristic feature of hypertensive kidney disease?

    <p>Cortical granularity and shrunken kidneys (A)</p> Signup and view all the answers

    What is the most common risk factor for renal cell carcinoma?

    <p>Smoking and hypertension (A)</p> Signup and view all the answers

    Which bacteria is most commonly associated with acute pyelonephritis?

    <p>Escherichia coli (B)</p> Signup and view all the answers

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