Veterinary Toxins and Temperature Quiz

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Questions and Answers

What type of toxins primarily affect the intestinal mucosa and cause hypersecretory diarrhea in neonatal farm animals?

  • Metabolic toxins
  • Endotoxins
  • Exotoxins (correct)
  • Neurotoxins

What are endotoxins primarily made of?

  • Nucleic acids
  • Lipopolysaccharides (correct)
  • Proteins
  • Carbohydrates

What is the major consequence of endotoxins being released into the bloodstream?

  • Coughing
  • Muscle spasms
  • Morbidity and mortality (correct)
  • Skin rashes

What condition can occur due to anaphylaxis from repeated biological preparations?

<p>Anaphylactic shock (A)</p> Signup and view all the answers

What is the primary cause of metabolic toxins in the body?

<p>Incomplete elimination of toxic materials (B)</p> Signup and view all the answers

Which of the following reactions is least likely to cause anaphylaxis upon the first injection?

<p>First antibiotic injection (A)</p> Signup and view all the answers

What causes edema in tissues?

<p>Fluid accumulation in the interstitial space (D)</p> Signup and view all the answers

Where does endotoxin gain access to the bloodstream primarily?

<p>During severe localized infection (D)</p> Signup and view all the answers

What is one condition that can lead to insufficient heat production in animals?

<p>Insufficient feed intake (B)</p> Signup and view all the answers

Which type of fever is characterized by little change in elevated temperature during a 24-hour period?

<p>Sustained/Continuous (A)</p> Signup and view all the answers

What condition could lead to excessive heat loss in an animal?

<p>Shock (A)</p> Signup and view all the answers

What is a potential cause of hyperthermia?

<p>High environmental temperature (B)</p> Signup and view all the answers

Which type of fever displays recurring elevated temperature separated by intervals of normal temperature?

<p>Intermittent (A)</p> Signup and view all the answers

Which of the following conditions may contribute to a decrease in skeletal muscle contraction?

<p>Certain diseases (A)</p> Signup and view all the answers

What is a characteristic of transient fever?

<p>Temperature returns to normal throughout the day (B)</p> Signup and view all the answers

Which of the following is NOT a cause of hyperthermia?

<p>Exposure to low environmental temperatures (C)</p> Signup and view all the answers

Which condition is primarily associated with increased hydrostatic pressure in capillaries?

<p>Chronic congestive heart failure (A)</p> Signup and view all the answers

What is one of the primary signs of chronic toxemia?

<p>Lethargy (C)</p> Signup and view all the answers

What major cause contributes to dehydration?

<p>Excessive fluid loss (D)</p> Signup and view all the answers

What condition is characterized by an increased body temperature that is independent of ambient conditions?

<p>Fever (Pyrexia) (B)</p> Signup and view all the answers

Which clinical sign indicates acute overhydration?

<p>Rapid ingestion of water (C)</p> Signup and view all the answers

Which of the following decreases as a result of decreased plasma oncotic pressure?

<p>Total protein concentration (B)</p> Signup and view all the answers

Which of the following is a cause of dehydration related to fever?

<p>Excessive muscular activity (A)</p> Signup and view all the answers

What is a common manifestation of toxic or septic shock due to toxin formation?

<p>Pallor of mucosa (A)</p> Signup and view all the answers

What is septicemia primarily associated with?

<p>Pathogenic bacteria causing septic shock (A)</p> Signup and view all the answers

Which condition is associated with abnormal depletion of body fluids?

<p>Dehydration (C)</p> Signup and view all the answers

Which toxic substance can lead to atypical fever due to poisoning?

<p>Levamisole (A), Dinitrophenols (D)</p> Signup and view all the answers

Which factor is NOT typically associated with the regulation of fever?

<p>Ambient temperature (C)</p> Signup and view all the answers

Which sign indicates both acute and chronic toxemia?

<p>Muscular weakness (B)</p> Signup and view all the answers

What is a major risk for newborn farm animals that fail to consume colostrum in the first 24 hours?

<p>Septicemia (A)</p> Signup and view all the answers

Which condition is associated with viruses invading the systemic circulation?

<p>Viremia (A)</p> Signup and view all the answers

What is a common cause of morbidity in horses related to temperature regulation?

<p>Administration of tranquilizers in hot weather (B)</p> Signup and view all the answers

What condition is primarily characterized by a reduction in circulating blood volume due to rapid loss of blood?

<p>Hemorrhagic Shock (C)</p> Signup and view all the answers

Which of the following is a common cause of acidosis?

<p>Increased acid production within the body (A)</p> Signup and view all the answers

What defines obstructive shock?

<p>Reduction in venous return caused by mechanical obstruction (B)</p> Signup and view all the answers

Hypocalcemia is associated with which of the following conditions?

<p>Hypovolemic Shock (A)</p> Signup and view all the answers

What primarily causes alkalosis?

<p>Excessive intake of bases or decreased acid levels (B)</p> Signup and view all the answers

Which electrolyte abnormality would NOT typically be associated with hypophosphatemia?

<p>Pain (D)</p> Signup and view all the answers

What physiological reaction primarily leads to pain perception?

<p>Stimulation of specific end-organs (B)</p> Signup and view all the answers

What could potentially cause hypomagnesemia?

<p>Electrolyte imbalances (A)</p> Signup and view all the answers

Which condition is most commonly associated with hyponatremia?

<p>Increased loss of sodium through the intestinal tract (D)</p> Signup and view all the answers

What is a possible consequence of hyperthermia in severe endotoxemia?

<p>Decreased systemic blood pressure (D)</p> Signup and view all the answers

Which electrolyte imbalance is likely associated with muscular weakness and recumbency?

<p>Hypokalemia (D)</p> Signup and view all the answers

What triggers shock in the context of severe endotoxemia?

<p>Reduction in venous return (A)</p> Signup and view all the answers

Hypochloremia is most likely to occur as a result of which condition?

<p>Net loss in the intestinal tract (C)</p> Signup and view all the answers

Which sign would be least expected in a patient suffering from severe endotoxemia?

<p>Improved level of consciousness (A)</p> Signup and view all the answers

What is a major electrolyte of concern during severe endotoxemia?

<p>Sodium (D)</p> Signup and view all the answers

Which symptom indicates the progression of severe endotoxemia toward shock?

<p>Increased heart rate (B)</p> Signup and view all the answers

Flashcards

Hyperthermia

A condition where the body's core temperature rises above its normal set point. This can be caused by exposure to excessive heat, prolonged physical exertion, or underlying medical conditions.

Exposure to Cold Air

A type of hyperthermia caused by exposure to cold air temperatures. The animal's inability to generate enough heat leads to a decrease in core body temperature.

Remittent Fever

A fever that fluctuates throughout the day but never reaches normal body temperature.

Sustained/Continuous Fever

A fever that remains elevated for extended periods with minimal fluctuations, typically not falling to normal.

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Transient Fever

A temporary increase in body temperature, often associated with a brief illness or infection.

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Intermittent Fever

A fever characterized by alternating periods of elevated body temperature and normal temperature.

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Neurogenic Hyperthermia

A type of hyperthermia caused by damage to the hypothalamus, the part of the brain that regulates temperature.

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Prolonged, Severe Muscular Exertion

Extreme muscular exertion can lead to hyperthermia due to the body's inability to dissipate the heat generated by intense muscle activity.

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Fever (Pyrexia)

A condition where the body's core temperature rises above the normal value and is not caused by environmental factors. This can be caused by infections, inflammations, and other conditions.

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Bacteremia

Bacteria are present in the bloodstream for a short period of time and do not cause clinical signs.

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Viremia

Invasion of the systemic circulation by pathogenic viruses with localization in various body tissues, causing characteristic lesions based on the specific virus.

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Septicemia

Acute invasion of the systemic circulation by pathogenic bacteria, accompanied by septic shock. This can lead to bacterial localization in various body systems or organs.

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Enterotoxins

These are toxins released by bacteria that primarily target the intestinal lining, causing disruptions in fluid balance and electrolyte levels, leading to diarrhea. An example is the toxin produced by enterotoxigenic E. coli, which causes watery diarrhea in young animals.

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Endotoxins

These are components of the outer membrane of Gram-negative bacteria. They are released when the bacteria die or break apart. Endotoxins can cause severe complications, including inflammation, fever, and even death.

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How Endotoxins Reach the Bloodstream

Endotoxins can enter the bloodstream when there is a severe infection, causing systemic effects. They can affect the blood vessels, leading to decreased blood pressure and shock.

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Metabolic Toxins

Toxins that build up in the body due to inefficient removal of normal metabolic byproducts or abnormal metabolic processes.

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Anaphylaxis

A severe, life-threatening allergic reaction that occurs when the body's immune system overreacts to an allergen. This can lead to rapid swelling, difficulty breathing, and dangerously low blood pressure.

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Edema

The accumulation of excess fluid in the spaces between tissues, often caused by problems with the lymphatic system or blood vessels.

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Anaphylactic Shock

This occurs when there is a sudden and severe antigen-antibody reaction, often leading to life-threatening complications if not treated promptly.

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Factors Contributing to Anaphylaxis

Repeated exposure to the same allergen, such as medications, vaccines, or blood transfusions, can increase the risk of anaphylaxis.

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Hyperthermia followed by Hypothermia

A condition where the body's core temperature rises above its normal set point, often followed by a drop in temperature. This may indicate a serious illness and is a common sign of endotoxemia.

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Tachycardia Followed by Decreased Cardiac Output

An abnormally fast heartbeat caused by the body's attempt to compensate for decreased blood pressure and oxygen levels. This is often a symptom of shock due to endotoxemia.

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Decreased Systemic Blood Pressure

A reduction in blood pressure that occurs when the body cannot adequately circulate blood. This can be caused by a variety of factors, including hypovolemia, hemorrhage, and maldistribution of blood. It often indicates an advanced stage of endotoxemia.

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Cool Skin and Extremities

This is often a clinical sign of endotoxemia because of the body's attempt to compensate for low blood pressure..

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Electrolyte Imbalances

The loss of electrolytes (sodium, chloride, potassium, calcium, and phosphorus) due to diseases of the alimentary tract. This is often a symptom of endotoxemia, as the body's immune response can cause significant fluid and electrolyte losses.

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Shock (Hypovolemic, Hemorrhagic, Maldistributive and Obstructive Shock)

A condition where the body is unable to maintain adequate blood pressure. This can occur due to a variety of factors, such as hypovolemia, hemorrhage, or maldistribution of blood. This is often a serious symptom of endotoxemia and can lead to organ damage if not addressed.

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Diarrhea

Fluid loss from the body, often a sign of severe intestinal inflammation and disruption.

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Congested mucosa with Increased CRT

Congestion and redness of the mucous membranes, often a sign of inflammation in the digestive tract.

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Hypovolemic Shock

A decrease in circulating blood volume due to the loss of blood, plasma, or free water.

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Hemorrhagic Shock

Occurs when there is reduction in circulating blood volume caused by rapid loss of blood.

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Maldistributive Shock

A type of shock characterized by a decrease in circulating blood volume due to increased capillary permeability and pooling of blood in the veins.

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Obstructive Shock

Shock caused by an obstruction in venous return, preventing blood from flowing back to the heart.

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Acidosis

An excess of acid in the blood, lowering its pH.

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Alkalosis

A condition where blood pH rises above normal, usually due to decreased acid or increased base.

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Pain

A distressing sensation arising from stimulation of specific end-organs in particular part of the body and perceived in the thalamus and cerebral cortex.

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Corticosteroid Side Effects

Administration of corticosteroids with mineralocorticoid activity can cause hypovolemia, hypocalcemia, hypophosphatemia, and hypomagnesemia.

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Study Notes

Manifestation of Clinical Diseases

  • A disease is an inability to perform physiological functions at normal levels, even with adequate nutrition and environment.
  • Systemic alterations are common during disease processes.
  • Infections can manifest locally or systemically, gradually developing over days to years.
  • Infections can affect multiple organs, and symptoms may resolve with treatment.

Systemic States

  • Hypothermia: Lower than normal body temperature, a major cause of neonatal mortality and morbidity. Causes include excessive heat loss (exposure to cold) and insufficient heat production (low energy reserves, poor feed intake). It can also be a symptom of other diseases.
  • Hyperthermia (Heat Stroke/Heat Exhaustion): Increased core body temperature often due to exposure to high environmental temperatures or strenuous exercise. Other contributing factors include neurogenic issues, dehydration, excessive activity, and various poisonings.

Fever Types

  • Septic Fever: Infection with bacteria, viruses, protozoa, or fungi, causing localized or systemic issues (bacteremia, endocarditis, septicemia).
  • Aseptic Fever: Fever associated with aseptic wounds, likely due to leukocyte breakdown or tissue damage.
  • Chemical Fever: Fever caused by substances like foreign proteins or dinitrophenols.
  • Surgical Fever: Fever due to tissue breakdown and inflammation (muscle damage, hemolytic crises, infarctions, neoplasms).

Forms of Fever

  • Transient: Body temperature fluctuates around normal during the day.
  • Sustained/Continuous: Little change in temperature over a 24-hour period (not exceeding 1°C variation).
  • Remittent: Temperature fluctuates but never reaches normal levels.
  • Intermittent: Recurring fever attacks with periods of normal temperature in between.
  • Atypical: Irregular temperature variations.

Septicemia and Viremia

  • Septicemia: Acute invasion of the bloodstream by pathogenic bacteria, often with septic shock and possible localization in organs.
  • Bacteremia: Bacteria in the bloodstream, not associated with clinical signs and not necessarily causing sepsis or shock.
  • Viremia: Pathogenic viruses in the bloodstream potentially affecting tissues.

Toxemia and Endotoxemia

  • Toxemia: Widespread host response to toxins from bacteria or tissue damage; detectable toxins in the blood are crucial for diagnosis.
  • Two classifications of toxins are: 1) Antigenic toxins which are often produced by bacteria and helminth parasites and stimulate antibody production and 2) Metabolic toxin toxins that result from incomplete elimination or abnormal metabolism of body materials

Fever (Pyrexia)

  • Increased body temperature independent of environmental conditions.
  • A combination of hyperthermia and infection/inflammation, rising from a higher temperature setpoint by the body.
  • Mediated by endogenous pyrogens (produced by immune cells) and exogenous pyrogens (bacteria, viruses, toxins).

Pain (Nociception)

  • Pain is a distressing sensation resulting from stimulation of specific nerve endings. There are three types: cutaneous, visceral, and somatic.

Stress

  • A systemic state resulting from long-term exposure to stressors.
  • May lead to psychosomatic diseases, increased susceptibility to infections, and decreased productivity in animals.

Localized Infections

  • Abscess: Localized collection of pus, often occurring in response to infection or foreign material.

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