VET 214 Echocardiography-2: Principles and Assessment

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Questions and Answers

In echocardiography, which view is typically used to visualize the Four-Chamber view of the heart?

  • Subcostal
  • Right Parasternal Long Axis (correct)
  • Left Apical
  • Right Parasternal Short Axis

What does 'LVIDd' stand for in echocardiography measurements?

  • Lateral Ventricular Internal Diameter during diastole
  • Left Ventricular Isovolumic Dimension during diastole
  • Left Ventricular Internal Diameter during diastole (correct)
  • Left Ventricular Intramural Depth during diastole

The formula for Fractional Shortening (FS) in M-mode echocardiography is:

  • $(LVIDd + LVIDs) / LVIDd * 100$
  • $(LVIDs - LVIDd) / LVIDs * 100$
  • $(LVIDd - LVIDs) / LVIDs * 100$
  • $(LVIDd - LVIDs) / LVIDd * 100$ (correct)

A normal Fractional Shortening (FS) in dogs, as assessed by M-mode echocardiography, is typically:

<p>Around 30% or greater (A)</p> Signup and view all the answers

In the context of M-mode LV measurements, 'normalization' often involves dividing the measured value by a factor related to:

<p>Body weight (D)</p> Signup and view all the answers

According to Cornell et al. (JVIM 2004), the formula for normalized LVIDd (LVIDdN) is:

<p>$LVIDd BW^{0.294}$ (C)</p> Signup and view all the answers

What is considered an abnormal LVIDdN value according to the JVIM 2004 paper?

<blockquote> <p>1.85 (D)</p> </blockquote> Signup and view all the answers

Ejection Fraction (EF) is a measure of:

<p>Global systolic function (C)</p> Signup and view all the answers

Simpson's method of discs is used in 2D echocardiography to calculate:

<p>Volumetric measurements of the left ventricle (B)</p> Signup and view all the answers

A normal Ejection Fraction (EF) in dogs, as assessed by 2D echocardiography, is typically:

<p>45-50% and above (A)</p> Signup and view all the answers

For 2D LV measurements normalization, Visser et al. (JVIM 2019) published which formula for LVIDdN?

<p>$LVIDd BW^{0.316}$ (A)</p> Signup and view all the answers

What is considered an abnormal LVIDdN value according to the JVIM 2019 paper by Visser et al.?

<blockquote> <p>1.61 (B)</p> </blockquote> Signup and view all the answers

The LA-to-Ao ratio is measured in which echocardiographic view?

<p>Right Parasternal Short Axis at the heart base (C)</p> Signup and view all the answers

An LA-to-Ao ratio greater than 1.3 is considered:

<p>Abnormal in the paper (Hansson et al. JVIM 2002) (A)</p> Signup and view all the answers

An LA-to-Ao ratio greater than 1.6 indicates:

<p>Significant left atrial enlargement (LAE) (C)</p> Signup and view all the answers

In dogs with Degenerative Mitral Valve Disease (DMVD), increased LA and LV measurements are clinically relevant because they can indicate:

<p>Disease severity and progression (B)</p> Signup and view all the answers

According to ACVIM consensus guidelines for DMVD, for asymptomatic dogs, an LVIDdN > 1.7 and LA:Ao > 1.6 are indications to:

<p>Start pimobendan therapy (B)</p> Signup and view all the answers

In systemic hypertension in dogs, echocardiography is used to assess:

<p>Left ventricular wall thickness (D)</p> Signup and view all the answers

Which of the following is NOT a characteristic of the right heart compared to the left heart on a 2D echocardiogram?

<p>R &lt; L (Right ventricle is more cranial/to the left) (D)</p> Signup and view all the answers

In cats with Hypertrophic Cardiomyopathy (HCM), which measurement is considered the most important index to guide therapy and prognosis?

<p>Left atrial size (C)</p> Signup and view all the answers

In cats, a normal Left Ventricular Internal Diameter in diastole (LVIDd) is typically in the range of:

<p>11-18 mm (D)</p> Signup and view all the answers

In Doppler echocardiography, blood flow follows two main principles:

<p>Driving pressure and path of least resistance (B)</p> Signup and view all the answers

In mitral inflow profile assessment, the 'E wave' represents:

<p>Early diastolic filling velocity (C)</p> Signup and view all the answers

High Left Atrial Pressure (LAP) is often described as the 'end-product' of:

<p>All left heart diseases (B)</p> Signup and view all the answers

A normal E wave velocity in mitral inflow profile is typically:

<p>&lt; 1 m/s (D)</p> Signup and view all the answers

In ventricular outflow assessment using Doppler, a velocity greater than 2 m/s in the aortic outflow profile may indicate:

<p>Outflow obstruction or increased blood flow (C)</p> Signup and view all the answers

Medical ultrasound (including Doppler) directly measures:

<p>Velocity of blood flow (A)</p> Signup and view all the answers

The simplified Bernoulli's equation used in echocardiography to estimate pressure gradient (P) is:

<p>P = 4V (C)</p> Signup and view all the answers

In the simplified Bernoulli's equation (P = 4V), 'V' represents:

<p>Velocity of blood flow (B)</p> Signup and view all the answers

In SI units, the factor of '4' in the simplified Bernoulli's equation (P = 4V) approximates:

<p>Fluid density of blood multiplied by 2 (C)</p> Signup and view all the answers

According to the table of normal intracardiac pressures, what is the normal systolic pressure in the right ventricle (RV) in small animals?

<p>25 mmHg (A)</p> Signup and view all the answers

What is the normal diastolic pressure in the aorta in small animals?

<p>90 mmHg (B)</p> Signup and view all the answers

In a case of severe pulmonary stenosis with a Doppler velocity of 5 m/s across the pulmonic valve, what is the estimated pressure gradient (PG) using the simplified Bernoulli's equation?

<p>100 mmHg (B)</p> Signup and view all the answers

If the estimated pressure gradient (PG) across the pulmonic valve is 100 mmHg and the right atrial pressure is assumed to be 20 mmHg, what is the estimated Right Ventricular Systolic Pressure (RVSP)?

<p>120 mmHg (C)</p> Signup and view all the answers

In a case of pulmonary hypertension with a tricuspid regurgitation velocity of 5 m/s, what is the estimated pressure gradient (PG) using the simplified Bernoulli's equation?

<p>100 mmHg (D)</p> Signup and view all the answers

If the estimated pressure gradient from tricuspid regurgitation is 100 mmHg and the right atrial pressure is assumed to be 5 mmHg, what is the estimated Pulmonary Artery Systolic Pressure (PASP)?

<p>105 mmHg (D)</p> Signup and view all the answers

Which statement is true regarding Doppler echocardiography?

<p>Spectral Doppler is highly operator dependent. (A)</p> Signup and view all the answers

When using Doppler echocardiography in clinical practice, it is crucial to:

<p>Diagnose and treat patients, not just numbers. (D)</p> Signup and view all the answers

Which of the following best describes the 'Continuity of Flow' principle in hemodynamics?

<p>Mass flow rate is constant in a closed system. (A)</p> Signup and view all the answers

In the context of the Extended Bernoulli's equation, the term $\int_{1}^{2} \frac{2 \bar{v}}{dt} \times d\bar{s}$ represents:

<p>Flow acceleration (C)</p> Signup and view all the answers

Why is the simplified Bernoulli equation (P = 4V) considered sufficient for clinical echocardiography in cases of stenosis, valve regurgitation, or shunts?

<p>Because flow acceleration is the dominant factor and viscous friction is minimal. (C)</p> Signup and view all the answers

In echocardiography, which view is most appropriate for assessing the LA-to-Ao ratio?

<p>Right Parasternal Short Axis view at the heart base (A)</p> Signup and view all the answers

According to Cornell et al. (JVIM 2004), what is the threshold LVIDdN value above which the measurement is considered abnormal?

<p>LVIDdN &gt; 1.85 (D)</p> Signup and view all the answers

What is meant by 'normalization' of M-mode LV measurements, such as LVIDd?

<p>Dividing the measured value by a factor related to body size to account for allometric scaling (A)</p> Signup and view all the answers

What does the 'E wave' represent in mitral inflow profile assessment using Doppler echocardiography?

<p>Early ventricular filling (B)</p> Signup and view all the answers

If a dog has a tricuspid regurgitation velocity of 4 m/s, what is the estimated pressure gradient (PG) using the simplified Bernoulli equation?

<p>64 mmHg (A)</p> Signup and view all the answers

In cats with hypertrophic cardiomyopathy (HCM), which measurement or assessment is considered the most important index to guide therapy and prognosis?

<p>Left atrial size (A)</p> Signup and view all the answers

What is the underlying principle behind using Doppler echocardiography to estimate pressure gradients across a stenotic valve?

<p>The Bernoulli principle (C)</p> Signup and view all the answers

In the context of the extended Bernoulli equation, what does the term $\int_{1}^{2} \frac{2 \bar{v}}{dt} \times d\bar{s}$ account for that is ignored in the simplified equation?

<p>Flow acceleration (D)</p> Signup and view all the answers

Which of the following best explains why measurements in echocardiography for cats are typically not normalized?

<p>Cats tend to be of similar size, so normalization provides little additional benefit. (D)</p> Signup and view all the answers

Consider a scenario where a dog presents with clinical signs suggestive of both mitral regurgitation and pulmonary hypertension. Tricuspid regurgitation velocity is measured at 4.5 m/s, and right atrial pressure is estimated at 8 mmHg. Given these findings, what is the estimated pulmonary artery systolic pressure (PASP), considering the potential impact of mitral regurgitation on pulmonary pressures?

<p>Approximately 97 mmHg, which is borderline for pulmonary hypertension and warrants further investigation (A)</p> Signup and view all the answers

In right parasternal long axis views of the heart, which chamber is typically located at the top of the four-chamber view?

<p>Right ventricle (A)</p> Signup and view all the answers

Which view allows visualization of the aorta in addition to the standard four chambers of the heart?

<p>Right parasternal long axis five-chamber outflow view (A)</p> Signup and view all the answers

In the right parasternal short axis view at the heart base, which structure is often referred to as the 'Mercedes' or 'Mercedes-Benz sign'?

<p>Aortic valve (A)</p> Signup and view all the answers

When measuring the LA-to-Ao ratio, at what point in the cardiac cycle should the measurements be taken?

<p>When the aortic valve closes (D)</p> Signup and view all the answers

What does Fractional Shortening (FS) assess?

<p>The percentage of change in left ventricular dimension during systole (C)</p> Signup and view all the answers

What is the primary reason for normalizing left ventricular measurements in echocardiography?

<p>To account for differences in breed and body size among animals (B)</p> Signup and view all the answers

What is the Simpson's method of disks used for in echocardiography?

<p>Calculating the volume of the left ventricle (A)</p> Signup and view all the answers

According to the information provided, when is an ejection fraction considered normal in dogs?

<p>45%-50% (B)</p> Signup and view all the answers

In the context of degenerative mitral valve disease (DMVD) in dogs, what does the presence of increased LA and LV dimensions typically indicate?

<p>Progression of the disease and potential for heart failure (C)</p> Signup and view all the answers

According to the information provided, what is the key measurement used to guide therapy and assess prognosis in cats with hypertrophic cardiomyopathy (HCM)?

<p>Left atrial size (A)</p> Signup and view all the answers

According to the information provided, blood flow follows two main principles. Which of the following dictates how fast blood flows:

<p>Driving pressure (D)</p> Signup and view all the answers

In the context of the Frank-Starling principle, how does an increased left ventricular diastolic dimension affect the subsequent contraction?

<p>It results in a more vigorous contraction, up to a certain point. (B)</p> Signup and view all the answers

What can cause a falsely normal fractional shortening or ejection fraction?

<p>Altered diastolic dimension (A)</p> Signup and view all the answers

How does persistent systemic hypertension affect the left ventricle?

<p>Both B and C (D)</p> Signup and view all the answers

In general, how does the size and wall thickness of the normal right heart compare to the left heart on a 2D echocardiogram?

<p>The right heart appears smaller with thinner walls. (C)</p> Signup and view all the answers

According to the information provided, what is the diagnostic criterion for hypertrophic cardiomyopathy (HCM) in cats, based on left ventricular wall thickness?

<p>A wall thickness greater than 6 mm in any segment of the left ventricle (A)</p> Signup and view all the answers

What determines the height/velocity of the 'E wave' in mitral inflow profile?

<p>The pressure gradient between the left atrium and the left ventricle (A)</p> Signup and view all the answers

According to the information provided, medical ultrasound directly measures:

<p>Velocity of fluids (A)</p> Signup and view all the answers

According to the information provided, what is the simplified Bernoulli equation?

<p>$P = 4V^2$ (A)</p> Signup and view all the answers

In the simplified Bernoulli equation, what does 'V' represent?

<p>Velocity of blood flow (C)</p> Signup and view all the answers

According to the information provided, the simplified Bernoulli equation is derived from what principle?

<p>The conservation of energy. (B)</p> Signup and view all the answers

Why doesn't the simplified Bernoulli equation account for the V1 (initial) velocity?

<p>V1 is usually close to 1 to 1.5 meters per second, which negligibly affects the final number. (C)</p> Signup and view all the answers

A six-month-old French Bulldog puppy is diagnosed with congenital pulmonic stenosis. The maximum velocity across the stenotic pulmonic valve is measured at 4.0 m/s. Using the simplified Bernoulli equation, what is the estimated pressure gradient across the valve?

<p>64 mmHg (C)</p> Signup and view all the answers

After calculating a pressure gradient of 64 mmHg across the stenotic pulmonic valve in the previous question, and assuming a normal right atrial pressure of 5 mmHg, what is the estimated right ventricular systolic pressure (RVSP)?

<p>69 mmHg (C)</p> Signup and view all the answers

A 7-year-old Pit Bull presents with syncope and is diagnosed with pulmonary hypertension. Tricuspid regurgitation is detected, with a velocity of 4.5 m/s. Estimate the pressure gradient across the tricuspid valve using the simplified Bernoulli equation.

<p>81 mmHg (D)</p> Signup and view all the answers

Given a pressure gradient of 81 mmHg across the tricuspid valve (estimated from the previous question) and assuming a right atrial pressure of 5 mmHg, estimate the pulmonary artery systolic pressure (PASP).

<p>86 mmHg (A)</p> Signup and view all the answers

What is the primary limitation of using Doppler echocardiography to assess cardiac function and hemodynamics?

<p>It is highly operator-dependent, leading to potential variability in results. (C)</p> Signup and view all the answers

Why is the right heart challenging to assess with echocardiography, compared to the left heart?

<p>The right heart has a more complex, crescent shape that wraps around the left ventricle, making it difficult to image comprehensively. (D)</p> Signup and view all the answers

When there is no obstruction between the right ventricle and pulmonary artery, the RV systolic pressure should be equivalent to:

<p>Pulmonary arterial systolic pressure (D)</p> Signup and view all the answers

If you're seeing normal ranges when measuring for fractional shortening, but the diastolic dimension is high/dilated, and the systolic dimension did not come down to normal, should you consider the function to be normal?

<p>No (C)</p> Signup and view all the answers

In a patient, if you suspect right heart disease, you can look for abnormalities based on certain indications based on what is "usually" seen in 2D. Which assessment is correct?

<p>All of the above. (D)</p> Signup and view all the answers

What can be said of systolic function?

<p>All of the above. (D)</p> Signup and view all the answers

A seven-year-old pit bull presented for syncope. You diagnose based on your echocardiographic findings to be pulmonary hypertension with tricuspid regurgitation. A drug is then prescribed that causes systemic vascular resistance vasodilation. What will be the net effect?

<p>The PASP may be lower and an increased risk of worsening right-sided heart failure (D)</p> Signup and view all the answers

In reference to the AI illustration of the heart doing a bench press, if the heart muscle is healthy but has too much weight on the bar, what will you see. And does that mean the contractility is unhealthy/abnormal?

<p>The muscle is struggling based on the reading, but the contractility can still be normal. (D)</p> Signup and view all the answers

A Doberman presents to your clinic and is diagnosed with dilated cardiomyopathy (DCM). You perform an echocardiogram and determine that the left ventricular systolic dimension (LVIDs) is significantly elevated, despite a normal left ventricular diastolic dimension (LVIDd). Fractional shortening (FS) is calculated to be within the normal range. What is the most likely explanation for these findings?

<p>The normal FS is a false reading due to the LVIDs not coming down to normal, revealing that the ventricles did not contract as much as it should have. (D)</p> Signup and view all the answers

A Great Dane presents with an LA:Ao of 1.4. Is this normal or abnormal.

<p>It depends on the preference of the person reading the results. (D)</p> Signup and view all the answers

A dog presents with severe mitral regurgitation. You take an echocardiogram and notice the mitral valve appears thickened and doesn't close completely during systole. What visible characteristic in color Doppler would confirm mitral regurgitation?

<p>A mosaic/turbulent color pattern indicating high-velocity, turbulent flow within the left atrium. (B)</p> Signup and view all the answers

According to the information provided, the end product of any left-sided heart disease is:

<p>High left atrial pressure (D)</p> Signup and view all the answers

An echocardiogram indicates elevated aortic outflow/velocity. According to the lecture, what COULD that indicate?

<p>There's an off-flow obstruction, or blood overload (D)</p> Signup and view all the answers

In right parasternal long axis views, which chamber is located most cranially in the four-chamber view?

<p>Right Ventricle (D)</p> Signup and view all the answers

Which echocardiographic view is characterized by the 'Mercedes-Benz sign'?

<p>Right Parasternal Short Axis at the Heart Base (A)</p> Signup and view all the answers

When should the LA-to-Ao ratio be measured?

<p>When the aortic valve closes. (D)</p> Signup and view all the answers

What does Fractional Shortening (FS) primarily assess?

<p>The percentage change in left ventricular dimension during systole (A)</p> Signup and view all the answers

What is the main reason for creating 'normalized' left ventricular measurements?

<p>To account for variations in body size and breed (A)</p> Signup and view all the answers

What information does the E wave provide in mitral inflow profile assessment?

<p>The velocity of early diastolic filling (C)</p> Signup and view all the answers

In the context of M-mode echocardiography, what does LVIDd represent?

<p>Left Ventricular Internal Diameter in diastole (D)</p> Signup and view all the answers

Which of the following best describes the right heart's characteristics, compared to the left heart, in a normal 2D echocardiogram?

<p>Thinner ventricular walls and smaller chamber sizes (D)</p> Signup and view all the answers

An LA-to-Ao ratio greater than 1.6 in dogs typically indicates:

<p>Significant left atrial enlargement (B)</p> Signup and view all the answers

In a dog with degenerative mitral valve disease (DMVD), increased LA and LV dimensions are most clinically relevant for indicating:

<p>Progression of the disease and increased risk of heart failure (A)</p> Signup and view all the answers

In Doppler echocardiography, what information does the driving pressure provide concerning the blood flow?

<p>How fast the blood flows (A)</p> Signup and view all the answers

What does an elevated aortic outflow velocity, as assessed by Doppler echocardiography, typically indicate?

<p>Aortic stenosis or increased blood flow (A)</p> Signup and view all the answers

What is the normal systolic pressure of the right ventricle in small animals?

<p>20-25 mmHg (B)</p> Signup and view all the answers

Why is accurate Doppler technique essential?

<p>Variations in approach widely alter results, severely skewing the conclusion of the echocardiogram. (D)</p> Signup and view all the answers

What potential effect can persistent systemic hypertension have on the left ventricle?

<p>Hypertrophy (thickening) of the left ventricular walls (D)</p> Signup and view all the answers

Which of the following is most likely when systolic dimension does not reach normal dimensions with a high/dilated diastolic dimension?

<p>Abnormal systolic function (A)</p> Signup and view all the answers

Why is assessing the right heart with echocardiography often more challenging compared to assessing the left heart?

<p>The right heart's complex shape and position make it difficult to image completely (C)</p> Signup and view all the answers

Which of the following is true regarding the assessment of pressure and blood flow? (Select the best answer)

<p>Medical ultrasound (Doppler) measures the speed of blood flow (B)</p> Signup and view all the answers

How might severe mitral regurgitation influence left ventricular systolic performance as assessed by fractional shortening (FS)?

<p>FS can be falsely normal or even high due to decreased afterload. (D)</p> Signup and view all the answers

What is one reason the right heart can be difficult to assess?

<p>The right heart wraps around the left heart putting it in an awkward position to image (D)</p> Signup and view all the answers

How does a drug that causes systemic vascular resistance vasodilation during treatment for pulmonary hypertension with tricuspid regurgitation affect the heart?

<p>Potentially reduces tricuspid regurgitation. (B)</p> Signup and view all the answers

An echocardiogram technician tells you normalization isn't typically done for feline measurements. Which option is the most likely reason for this?

<p>Cats are generally about the same size (A)</p> Signup and view all the answers

When the right ventricle and pulmonary artery path is wide open, the RV systolic pressure should be:

<p>Equivalent to the pulmonary arterial pressure (A)</p> Signup and view all the answers

What is the significance of left atrial pressure (LAP) in the context of heart disease?

<p>End product of any left-sided heart disease (A)</p> Signup and view all the answers

What is the key consideration when employing the simplified Bernoulli equation ($P = 4V^2$) in clinical echocardiography?

<p>The equation is adequate for estimating pressure gradients in cases of valve regurgitation, stenosis, or shunts. (C)</p> Signup and view all the answers

Under what circumstance might a fractional shortening measurement lead to a misleading conclusion about systolic function?

<p>Contracting dehydration. the diastatic chamber is very small. (A)</p> Signup and view all the answers

What is the most likely reason fractional shortening or ejection fraction might appear normal, despite the heart NOT performing normally?

<p>Systolic dimension does not contract to normal dimensions (A)</p> Signup and view all the answers

If the heart muscle is healthy but you're seeing struggling on your imaging, what is true of the contractility?

<p>Normal (B)</p> Signup and view all the answers

In advanced imaging, the heart is illustrated on a bench press struggling. Which of the following defines 'systolic function'?

<p>Imaging parameter after loading conditions (B)</p> Signup and view all the answers

Which best describes the 'path of least resistance' principle in the context of blood flow dynamics?

<p>Blood flows where the resistance is minimal (B)</p> Signup and view all the answers

What does the speaker describe as, 'more than 50% of the time what cardiologists do.'?

<p>Eyeballing or image interpretation (C)</p> Signup and view all the answers

What does the speaker say is a common critique of the normalization process described by Cornell et al. (JVIM 2004)

<p>Measurements are too forgiving (C)</p> Signup and view all the answers

In right parasternal long axis views of the heart, which chamber is typically located most cranially in the four-chamber view?

<p>Right Ventricle (C)</p> Signup and view all the answers

Which echocardiographic view is characterized by the 'Mercedes-Benz sign', representing the aortic valve cusps?

<p>Right Parasternal Short Axis at the Heart Base View (B)</p> Signup and view all the answers

When should the LA-to-Ao ratio be measured in the cardiac cycle to ensure consistency and accuracy?

<p>When the Aortic Valve Closes (D)</p> Signup and view all the answers

What does Fractional Shortening (FS) primarily assess in M-mode echocardiography?

<p>The percentage change in left ventricular dimension during systole (B)</p> Signup and view all the answers

What is the main reason for creating 'normalized' left ventricular measurements in echocardiography?

<p>To account for variations in patient size and breed (D)</p> Signup and view all the answers

What information does the E wave provide in mitral inflow profile assessment using Doppler echocardiography?

<p>Early ventricular filling velocity (C)</p> Signup and view all the answers

According to the provided lecture, what is the normal systolic pressure of the right ventricle in small animals?

<p>20-25 mmHg (B)</p> Signup and view all the answers

Why is accurate Doppler technique essential for reliable echocardiographic assessments?

<p>Because Doppler findings are highly operator-dependent and can significantly alter interpretations (B)</p> Signup and view all the answers

What potential effect can persistent systemic hypertension have on the left ventricle, as visualized on echocardiogram?

<p>Left ventricular hypertrophy (thickening of walls) and reduced chamber size (B)</p> Signup and view all the answers

Which of the following is most likely when systolic dimension does not reach normal dimensions with a high/dilated diastolic dimension, despite a seemingly normal fractional shortening?

<p>Underlying systolic dysfunction masked by the Frank-Starling mechanism (B)</p> Signup and view all the answers

Which of the following is true regarding the assessment of pressure and blood flow in echocardiography? (Select the best answer)

<p>Echocardiography uses Doppler to measure velocity and estimates pressure gradients based on the Bernoulli equation. (C)</p> Signup and view all the answers

Consider a scenario where a dog presents with clinical signs suggestive of both mitral regurgitation and pulmonary hypertension. Tricuspid regurgitation velocity is measured at 4.5 m/s, and right atrial pressure is estimated at 8 mmHg. Given these findings, what is the estimated pulmonary artery systolic pressure (PASP)?

<p>89 mmHg (D)</p> Signup and view all the answers

Flashcards

M-mode LV measurement

A method to measure left ventricular size.

Allometric Scaling

Used normalize LV measurements; accounts for body size differences.

2D LV measurement

A 2D measure of the LV.

Ejection Fraction

The percentage of blood ejected from the LV with each contraction.

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LA-to-Ao Ratio

Ratio comparing left atrial size to aortic size; assesses atrial enlargement.

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DMVD

A disease in which the mitral valve doesn't close properly, eading to regurgitation.

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Right Heart Assessment

Measures of the heart which are often overlooked.

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HCM in cats

A common heart condition in cats; involves thickening of the heart muscle.

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Doppler Echocardiography

A technique to assess blood flow velocities and direction.

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Mitral Valve Opening

The beginning of diastole.

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Ventricular Outflow

Estimating driving pressure.

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Doppler Limitations

States that medical ultrasound can't measure pressure.

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Continuity of Flow

A principle of conservation of mass in fluid dynamics.

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Bernoulli's Principle

A statement that pressure is potential energy.

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Bernoulli's equation

It's an equation for steady flow.

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Solving PGs

The point should you use the full equation.

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Simplified Bernoulli Equation

It's a simplified version.

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Doppler caution

Use the right kind of transducer.

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What is the left ventricle?

The chamber on the top on the left in a short axis view.

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What is the right ventricle?

The chamber on the top on the right in a short axis view.

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What is fractional shortening?

Fractional shortening reflects the LV contraction.

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What is normal ejection fraction?

A percentage representing how much the left ventricle empties with each beat.

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What is Simpson's method of disks?

A technique to estimate left ventricular volume.

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What is systemic hypertension?

Persistent high blood pressure.

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What is Frank-Starling principle?

When myocardial cells are stretched, they contract with more force.

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What is contractility?

Inherent property of myocardial cells, independent of loading conditions.

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What is systolic function?

Imaging parameter reflecting end result of loading conditions.

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What is pulmonary valve stenosis?

Pulmonary valve doesn't open well.

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What is pulmonary hypertension?

A condition where the pulmonary arterial pressure gets elevated.

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What is tricuspid regurgitation?

A disease where blood leaks through the tricuspid valve.

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Study Notes

  • The lecture focuses on interpreting echocardiogram measurements and introduces advanced concepts.

Review of Echocardiography Views

  • Right Parasternal Long Axis views include the four-chamber and five-chamber (outflow) view.
  • Key anatomical structures in these views: right ventricle, right atrium, tricuspid valve, left ventricle, left atrium, mitral valve, interventricular septum, interatrial septum, and aorta with the aortic valve.
  • Right Parasternal Short Axis views show the left ventricle with papillary muscles and the mitral valve.
  • Key anatomical structures: left ventricle, right ventricle, interventricular septum, papillary muscles, and mitral valve ("fish mouth").
  • Heart base views visualize the left atrium and pulmonary artery.
  • Key anatomical structures: aortic valve (Mercedes-Benz sign), left atrium (whale), right atrium, right ventricle, tricuspid valve, internatural septum, pulmonary trunk/artery, pulmonary valve, and pulmonary arteries.
  • Left Apical views include the five-chamber and four-chamber views.
  • Key anatomical structures: left ventricle, left atrium, aorta, mitral valve, aortic valve, right ventricle, right atrium, and tricuspid valve.

2D and M-Mode Measurements of the Left Ventricle (LV)

  • M-mode measurements visualize LV contraction, allowing measurement of diastolic (LVIDd) and systolic (LVIDs) dimensions.
  • LVIDd indicates LV size; elevated in dilation, reduced in dehydration.
  • Systolic dimension (LVIDs) reflects LV function.
  • Fractional Shortening (FS) measures the percentage of LV contraction: FS (%) = (LVIDd - LVIDs) / LVIDd x 100; normal is around 30% or greater.
  • Significantly low FS (e.g., 10-15%) indicates abnormality.

Normalization of LV Measurements

  • Normalization adjusts measurements for body size differences between animals (e.g., Chihuahua vs. Irish Wolfhound).
  • Cornell normalization is considered too forgiving.
  • Breed-specific references are preferred when available.
  • Formulas for Allometric Scaling (Cornell et al., JVIM 2004):
    • LVIDdN = LVIDd ÷ BW^0.294
    • LVIDsN = LVIDs ÷ BW^0.315
  • Abnormal values in the paper: LVIDdN > 1.85, LVIDsN > 1.26.
  • Cut-off values depend on the clinical context.

2D LV Measurements: Volumetric

  • 2D measurements allow for direct measurement of LV dimensions without M-mode.
  • Simpson's method of discs estimates LV volume. The machine assumes geometric, splits volume into many little discs, calculates it, and sums for a calculated 3D volume.
  • Ejection Fraction (EF) assesses volumetric function: EF (%) = (LVVd -LVVS)/LVVd x 100; normal is 45-50% and above.
  • EF is a key parameter for categorizing heart disease and heart failure.

Normalization of Volumetric Measurements

  • Equations are used to normalize measurements.
  • Formulas were published by Visser et al. (JVIM 2019):
    • LVIDdN = LVIDd ÷ BW^0.316
    • LVIDSN = LVIDs ÷ BW^0.392
  • Abnormal values: LVIDdN > 1.61 and LVIDSN > 0.93
  • If there are breed-specific measurements, use those over standard equations.

Interpretation Considerations for LV Systolic Function

  • Systolic dimension should always be within the normal range, regardless of diastolic dimension.
  • Fractional shortening (FS) or ejection fraction (EF) can be falsely normal, low, or high based on diastolic dimension
  • Frank-Starling Principle: increased myocardial stretch (higher LVIDd) leads to more pronounced contraction.
  • High LVIDd + high LVIDs = Normal FS/EF with reduced function
  • Small LVIDd + higher normal LVIDs = Low FS/EF with normal function
  • Systolic function (imaging parameter) and contractility (cellular/tissue level) are different concepts.
  • Systolic function is the end result of loading conditions (preload, afterload).
  • Contractility is inherent to the muscle cells, independent of loading conditions.

Left Atrium (LA) Measurements: LA-to-Aorta (Ao) Ratio

  • Ao size is used as an internal scaling component for LA size.
  • Measured on Right Parasternal Short Axis (RPSAX) at the heart base (whale view) at end-systole (AV closure).
  • Measurement involves identifying the non-coronary and left coronary cusps of the aortic valve.
  • Draw a line across the closure line (bisecting the aortic valve) to measure the Ao diameter.
  • Draw a line along the same line to measure the LA dimension.
  • LA:Ao > 1.3 is abnormal.
  • LA:Ao > 1.6 indicates significant LA enlargement (LAE).
  • 1.5 is considered abnormal.

  • This measurement is very operator-dependent.

Clinical Relevance of LA and LV Measurements

  • Used in the diagnosis and management of Degenerative Mitral Valve Disease (DMVD).
  • The ACVIM consensus guidelines for DMVD diagnosis and treatment use these measurements.
  • For asymptomatic dogs, pimobendan treatment is initiated if:
    • LVIDdN > 1.7
    • LA:Ao > 1.6
  • Treatment based on Boswood et al. 2016 (EPIC trial).
  • Also used to assess the clinical relevance of LV wall thickness in dogs with systemic hypertension.

Assessment of the Right Heart

  • The right heart has a unique shape and anatomy (flat conical shape that wraps around the left heart).
  • Assess the size and thickness.
  • RV wall is thinner than LV.
  • Assessing the right heart is more nuanced and complicated.
  • Eyeballing art: The right heart should look smaller than the left heart (RA ‹ LA, RV ‹ LV).
  • The interventricular septum (IVS) should curve towards the RV due to lower pressure.
  • Disproportionately large right heart indicates abnormality.

Assessment of the Heart in Cats

  • The most common disease is hypertrophic cardiomyopathy (HCM), resulting in thickened and stiff ventricular walls with diastolic dysfunction.
  • Key measurements: LV wall thickness and LA size.
  • LA size is the most important index to guide therapy and prognosis.
  • Measurements are usually not normalized.
  • Important numbers:
    • Any LV segment > 6 mm indicates HCM.
    • Normal LVIDd ~11-18 mm.
    • Normal LA:Ao < 1.3; >1.6 indicates enlargement.
  • Systolic function is usually high-normal, but can be reduced in end-stage disease.

Doppler Echocardiography

  • Blood flow follows two principles: driving pressure and path of least resistance.

Mitral Inflow Profile

  • The mitral valve opens at the beginning of diastole, with early filling driven by left atrial pressure (LAP).
  • High LAP is the end-product of all left heart diseases.
  • E wave velocity increases as left atrial pressure increases (non-linear).
  • Normal values:
    • E < 1 m/s
    • A < 0.8 m/s

Ventricular Outflow

  • Normal outflow velocity for aortic and pulmonary valves < 2 m/s.
  • Elevated velocity can indicate outflow obstruction (stenosis) or increased blood flow (increased preload or shunt).
  • Small, instantaneous pressure gradients mean ventricular pressure rises faster than blood pressure.
  • Doppler is used to assess the severity of obstruction and estimate driving pressure.
  • Valve Regurgitation: Doppler assesses how high or low the pressure within the driving chamber (higher/lower than expected?).
  • Cardiac Shunts: Blood that flows from a high-pressure (systemic) to low-pressure (pulmonary) system.
  • Medical ultrasound cannot measure pressure directly.
  • Doppler measures blood flow velocity.
  • Velocity is used to estimate the driving pressure or pressure gradient (PG) across the orifice.

Doppler and Blood Flow: Principles

  • Apply Continuity of flow Conservation of mass: A1 x V1 = A2 x V2↑
  • Apply Bernoulli's principle Conservation of energy
    • P1-P2 = ½p(V22 - V12) + ∫12 dv/dt x ds + R (v)
  • Extended Bernoulli's equation for unsteady flow:
    • P1 - P2 = ½ρ(V22 - V12) + ∫12 dv/dt x ds + R (v)
    • Pressure decrease = convective + flow + viscous
    • acceleration acceleration friction

Solving Pressure Gradients (PGs)

  • Simplified Bernoulli's equation (used for stenosis, valve regurgitation, or shunts):
    • P1 - P2 = 4V2
  • Assumptions for simplification:
    • A small mass of fluid is being accelerated through a small hole.
    • Energy loss due to viscous friction is minimal
  • V₁ (proximal velocity) is close to 1-1.5 m/s

Examples of Normal Pressures:

Site Systolic Diastolic Mean
RA - - 3 (±2)
RV 25 (±5) 0-5 -
PA 25 (±5) 10 (±3) 15 (±5)
PA wedge 6 (±2) 4 (±2) 5 (±2)
LA - - -
LV 120 (±20) 0-8 -
Aorta 120 (±20) 90 (±10) 100 (±10)
Femoral artery 130 (±20) 90 (±10) 100 (±10)

Clinical Applications of Doppler Pressure Gradient

  • Case 1: 6-month-old French Bulldog with a murmur diagnosed with congenital pulmonary stenosis.
    • Pulmonary valve velocity = 5 m/s
    • Pressure gradient (PG) = 4 x 52 = 100 mmHg
    • RVSP = 100 + 20 = 120 mmHg (assuming normal PA pressure)
  • Case 2: 7-year-old Pit Bull presented for syncope and diagnosed with pulmonary hypertension.
    • Tricuspid regurgitation velocity = 5 m/s
    • PG = 4 x 52 = 100 mmHg
    • RVSP = 100 + 5 = 105 mmHg (assuming normal RA pressure)
    • PASP = RVSP = 105 mmHg

Cautions for Doppler Echocardiography

  • Doppler echocardiography is highly operator dependent with high variability, especially spectral Doppler.
  • Doppler findings should be integrated into all other measurements.
  • Base clinical decisions on patients, not solely on numerical Doppler values.

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