18 Questions
Which region of the liver acinus is closest to the entry of blood?
Zone 1
What structures are found at the corners of a liver lobule?
Portal triads
Which functional hepatic unit is formed by the terminal branches of the portal vein and hepatic artery?
Acinus
Where are the major functions of the liver altered detrimentally by exposure to toxicants?
At the centrolobular region
Which region of the acinus abuts the terminal hepatic vein?
Zone 3
Where in the liver is bioactivation and detoxification of substances mainly occurring?
Centrolobular region
Which zone of the acinus coincides with the periportal region of the lobule?
Zone 2
Where do structures like a branch of the portal vein, a hepatic arteriole, and a bile duct come together?
Portal triads
Which of the following is NOT a mechanism of toxin-induced injury to liver cells?
Stimulation of bile secretion
In canalicular cholestasis, which of the following is a characteristic biochemical finding?
Elevated serum bile salts and bilirubin
Which of the following is a consequence of chronic bile duct damage caused by toxin exposure?
Biliary proliferation and fibrosis
Which of the following is a biochemical index of bile duct damage?
Sharp elevation in serum alkaline phosphatase
Which of the following is a characteristic of sinusoidal damage in the liver?
Decreased blood flow through the sinusoids
Which of the following is a characteristic feature of jaundice associated with cholestasis?
Accumulation of bilirubin in the skin and eyes
Which of the following is a characteristic biochemical finding in cholangiodestructive cholestasis?
Elevated serum alkaline phosphatase
Which of the following is NOT a common mechanism of toxin-induced liver injury?
Increased mitochondrial biogenesis
Which of the following is a characteristic feature of bile duct damage caused by chronic toxin exposure?
Biliary proliferation and fibrosis
Which of the following is a characteristic feature of sinusoidal damage in the liver?
Progressive destruction of the sinusoidal endothelial cell wall
Test your knowledge on the early structural features of veno-occlusive disease and cirrhosis, both of which are related to liver disorders caused by different factors such as pyrrolizidine alkaloids. Understand the histological changes and consequences associated with these conditions.
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