Veno-occlusive Disease and Cirrhosis Quiz
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Questions and Answers

Which region of the liver acinus is closest to the entry of blood?

  • Centrolobular region
  • Zone 1 (correct)
  • Zone 3
  • Zone 2

What structures are found at the corners of a liver lobule?

  • Portal triads (correct)
  • Hepatic arterioles
  • Bile ducts
  • Central veins

Which functional hepatic unit is formed by the terminal branches of the portal vein and hepatic artery?

  • Portal triad
  • Acinus (correct)
  • Lobule
  • Central vein

Where are the major functions of the liver altered detrimentally by exposure to toxicants?

<p>At the centrolobular region (D)</p> Signup and view all the answers

Which region of the acinus abuts the terminal hepatic vein?

<p>Zone 3 (D)</p> Signup and view all the answers

Where in the liver is bioactivation and detoxification of substances mainly occurring?

<p>Centrolobular region (B)</p> Signup and view all the answers

Which zone of the acinus coincides with the periportal region of the lobule?

<p>Zone 2 (C)</p> Signup and view all the answers

Where do structures like a branch of the portal vein, a hepatic arteriole, and a bile duct come together?

<p>Portal triads (D)</p> Signup and view all the answers

Which of the following is NOT a mechanism of toxin-induced injury to liver cells?

<p>Stimulation of bile secretion (D)</p> Signup and view all the answers

In canalicular cholestasis, which of the following is a characteristic biochemical finding?

<p>Elevated serum bile salts and bilirubin (B)</p> Signup and view all the answers

Which of the following is a consequence of chronic bile duct damage caused by toxin exposure?

<p>Biliary proliferation and fibrosis (B)</p> Signup and view all the answers

Which of the following is a biochemical index of bile duct damage?

<p>Sharp elevation in serum alkaline phosphatase (D)</p> Signup and view all the answers

Which of the following is a characteristic of sinusoidal damage in the liver?

<p>Decreased blood flow through the sinusoids (C)</p> Signup and view all the answers

Which of the following is a characteristic feature of jaundice associated with cholestasis?

<p>Accumulation of bilirubin in the skin and eyes (D)</p> Signup and view all the answers

Which of the following is a characteristic biochemical finding in cholangiodestructive cholestasis?

<p>Elevated serum alkaline phosphatase (A)</p> Signup and view all the answers

Which of the following is NOT a common mechanism of toxin-induced liver injury?

<p>Increased mitochondrial biogenesis (C)</p> Signup and view all the answers

Which of the following is a characteristic feature of bile duct damage caused by chronic toxin exposure?

<p>Biliary proliferation and fibrosis (B)</p> Signup and view all the answers

Which of the following is a characteristic feature of sinusoidal damage in the liver?

<p>Progressive destruction of the sinusoidal endothelial cell wall (D)</p> Signup and view all the answers
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