Veno-occlusive Disease and Cirrhosis Quiz
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Questions and Answers

Which region of the liver acinus is closest to the entry of blood?

  • Centrolobular region
  • Zone 1 (correct)
  • Zone 3
  • Zone 2
  • What structures are found at the corners of a liver lobule?

  • Portal triads (correct)
  • Hepatic arterioles
  • Bile ducts
  • Central veins
  • Which functional hepatic unit is formed by the terminal branches of the portal vein and hepatic artery?

  • Portal triad
  • Acinus (correct)
  • Lobule
  • Central vein
  • Where are the major functions of the liver altered detrimentally by exposure to toxicants?

    <p>At the centrolobular region</p> Signup and view all the answers

    Which region of the acinus abuts the terminal hepatic vein?

    <p>Zone 3</p> Signup and view all the answers

    Where in the liver is bioactivation and detoxification of substances mainly occurring?

    <p>Centrolobular region</p> Signup and view all the answers

    Which zone of the acinus coincides with the periportal region of the lobule?

    <p>Zone 2</p> Signup and view all the answers

    Where do structures like a branch of the portal vein, a hepatic arteriole, and a bile duct come together?

    <p>Portal triads</p> Signup and view all the answers

    Which of the following is NOT a mechanism of toxin-induced injury to liver cells?

    <p>Stimulation of bile secretion</p> Signup and view all the answers

    In canalicular cholestasis, which of the following is a characteristic biochemical finding?

    <p>Elevated serum bile salts and bilirubin</p> Signup and view all the answers

    Which of the following is a consequence of chronic bile duct damage caused by toxin exposure?

    <p>Biliary proliferation and fibrosis</p> Signup and view all the answers

    Which of the following is a biochemical index of bile duct damage?

    <p>Sharp elevation in serum alkaline phosphatase</p> Signup and view all the answers

    Which of the following is a characteristic of sinusoidal damage in the liver?

    <p>Decreased blood flow through the sinusoids</p> Signup and view all the answers

    Which of the following is a characteristic feature of jaundice associated with cholestasis?

    <p>Accumulation of bilirubin in the skin and eyes</p> Signup and view all the answers

    Which of the following is a characteristic biochemical finding in cholangiodestructive cholestasis?

    <p>Elevated serum alkaline phosphatase</p> Signup and view all the answers

    Which of the following is NOT a common mechanism of toxin-induced liver injury?

    <p>Increased mitochondrial biogenesis</p> Signup and view all the answers

    Which of the following is a characteristic feature of bile duct damage caused by chronic toxin exposure?

    <p>Biliary proliferation and fibrosis</p> Signup and view all the answers

    Which of the following is a characteristic feature of sinusoidal damage in the liver?

    <p>Progressive destruction of the sinusoidal endothelial cell wall</p> Signup and view all the answers

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