Vector Properties in Gene Therapy Quiz
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Questions and Answers

What are some of the vector properties to be checked and described when proposing a new gene therapy approach?

  • Transduction efficiency, targeting, and immunogenicity
  • Safety, transduction efficiency, and production
  • Duration of the GT effect, targeting, and immunogenicity
  • Stability, expression level, and targeting (correct)
  • What is the main difference between IN VIVO and EX VIVO gene therapy delivery methods?

  • IN VIVO involves injecting the GT directly inside the cells, while EX VIVO involves retrieving cells from the patient (correct)
  • IN VIVO involves reaching the final organ directly, while EX VIVO involves retrieving cells from the patient
  • IN VIVO involves selecting transduced cells in vitro, while EX VIVO involves reaching the final organ directly
  • IN VIVO involves retrieving cells from the patient, while EX VIVO involves injecting the GT directly inside the cells
  • What does EX VIVO gene therapy delivery method involve?

  • Selecting transduced cells in vitro and injecting them back into the patient
  • Retrieving cells from the patient, transducing them in vitro, and selecting the transduced cells (correct)
  • Reaching the final organ directly by injecting the GT
  • Injecting the GT directly inside the cells
  • Which of the following is NOT considered one of the vector properties for gene therapy approval?

    <p>Type of effort required by pharmaceutical companies</p> Signup and view all the answers

    What does targeting refer to in the context of vector properties for gene therapy?

    <p>How to reach the desired cells</p> Signup and view all the answers

    In terms of vector properties for gene therapy, what does transduction efficiency represent?

    <p>How efficient the GT is in reaching and affecting the target cells</p> Signup and view all the answers

    What is an important consideration for in vivo delivery of gene therapy?

    <p>Transduction efficiency</p> Signup and view all the answers

    Which type of injection is used when the goal is to reach as many cells as possible in gene therapy?

    <p>Intravenous injection</p> Signup and view all the answers

    What is a challenge for the vector in systemic injection (intravenous) in gene therapy?

    <p>Survival in blood serum</p> Signup and view all the answers

    Which barrier does the vector need to pass through in order to reach target cells in the brain?

    <p>Endothelium of vessels</p> Signup and view all the answers

    What is the best way to deliver some proteins produced by connective tissue or dendritic cells?

    <p>Subcutaneous injection</p> Signup and view all the answers

    What type of injection route can be used for treating cardiac diseases with gene therapy?

    <p>Inhalation</p> Signup and view all the answers

    Which factor needs to be considered for in vivo gene therapy targeting metastatic cells in cancer?

    <p>Transduction efficiency</p> Signup and view all the answers

    What type of barrier does the vector need to pass through if the target cells are immune-privileged sites?

    <p>Endothelium of vessels</p> Signup and view all the answers

    Which delivery route can be used if the target tissue is easily accessible from the outside, like muscles?

    <p>Local injection</p> Signup and view all the answers

    What challenge is associated with vector dilution in the body fluids during intravenous injection?

    <p>Dilution effects of the vector in the system</p> Signup and view all the answers

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